Matrin 3 Protéines (MATR3)

This locus encodes a nuclear matrix protein. De plus, nous expédions Matrin 3 Anticorps (86) et Matrin 3 Kits (8) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MATR3 9782 P43243
MATR3 17184 Q8K310
Rat MATR3 MATR3 29150 P43244
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Showing 5 out of 5 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Wheat germ Humain GST tag 2 μg 11 to 12 Days
Escherichia coli (E. coli) Humain Inconjugué   1 mg 11 to 18 Days

MATR3 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , ,
, ,
Mouse (Murine)

Matrin 3 Protéines mieux référencés

  1. Human MATR3 Protein expressed in HEK-293 Cells - ABIN2725552 : Johnson, Pioro, Boehringer, Chia, Feit, Renton, Pliner, Abramzon, Marangi, Winborn, Gibbs, Nalls, Morgan, Shoai, Hardy, Pittman, Orrell, Malaspina, Sidle, Fratta, Harms, Baloh, Pestronk, Weihl et al.: Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. ... dans Nature neuroscience 2014 (PubMed)

Plus protéines pour Matrin 3 (MATR3) partenaires d'interaction

Human Matrin 3 (MATR3) interaction partners

  1. MATR3 regulates miR-138 in neurons, with important implications for miR-138 regulation during neuronal development, synaptic plasticity and memory-related processes.

  2. The intra-nuclear localization and interaction network of MATR3 is strongly modulated by its RRM2 domain.

  3. FUS, EWSR1, TAF15 and MATR3 within the RNAP II/U1 snRNP machinery play distinct roles in the development of amyotrophic lateral sclerosis and spinal muscular atrophy that are more intimately tied to one another than previously thought.

  4. The data of this study suggest that MATR3 may have regulatory mechanisms that are influenced by tissue type and/or mutation status

  5. PTBP1 and MATR3 co-bind and repress RNA processing within and around young LINEs

  6. In this work we identify the cellular protein MATR3 as an essential cofactor of viral RNA processing. Reactivation of HIV-1 transcription is not sufficient to allow completion of a full life cycle of the virus if MATR3 is depleted.

  7. cytoplasmic MATR3 redistribution mitigated neurodegeneration, suggesting that nuclear MATR3 mediates toxicity.

  8. This might contribute to cellular damage and progression of dystrophy in muscle of Matrin-3 myopathy

  9. Depletion of SAFB1 reduced FUS's localization to chromatin-bound fraction and splicing activity, suggesting SAFB1 could tether FUS to chromatin compartment thorough N-terminal DNA-binding motif. Moreover, FUS interacts with another nuclear matrix-associated protein, Matrin3.

  10. Using a novel RNA pulldown approach that utilized endogenous S1-tagged PINCR (a p53-regulated long noncoding RNA), the authors show that PINCR associates with the enhancer region of these genes by binding to RNA-binding protein Matrin 3 that, in turn, associates with p53.

  11. Matrin3 physically interacts with intronic pyrimidine-rich sequences and controls alternative splicing.

  12. It may not be a common genetic factor in Chinese amyotrophic lateral sclerosis patients.

  13. Its mutations strengthens the role of RNA metabolism in amyotrophic lateral sclerosis etiology.

  14. A missense mutation in MATR3 was identified in myopathy patients undergoing a needle electromyography.

  15. Our findings indicate that mutations in Matrin 3 that are associated with ALS and myopathy do not dramatically alter the normal localization of the protein or readily induce inclusion formation.

  16. Three-dimensional mapping of the lamin A-matrin-3 interface showed that the LMNA truncating mutation Delta303, which lacks the matrin-3 binding domain, was associated with an increased distance between lamin A and matrin-3.

  17. Suppressing Matrin 3 powers a heightened and broader ZAP restriction of HIV-1 gene expression.

  18. MATR3 mutation is identified to be a possible cause of amyotrophic lateral sclerosis.

  19. No mutations were identified, indicating that MATR3 mutations are not a common cause of Amyotrophic lateral sclerosis in Australian familial cases with predominately European ancestry

  20. MATR3 gene disruption is associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus.

Mouse (Murine) Matrin 3 (MATR3) interaction partners

  1. proteomic approach revealed that Matrin-3 phosphorylation was essential for FGF2-dependent maintenance of NSCs in vitro and in vivo.

  2. Matrin 3 (MATR3) is a novel protein interactor of PABPN1. MATR3 together with PABPN1 is required for normal paraspeckle function.

  3. Matrin 3 declines significantly in the central nervous system through early development and young adulthood before stabilizing.

  4. Matr3(Gt-ex13) gene trap insertion disturb the polyadenylation of MATR3 transcripts and alter Matrin 3 protein expression.

  5. Matrin 3 interacts specifically with the heat shock proteins glucose-regulated protein 78, GRP75 and glutathione S-transferase pi isoform 2.

  6. homeodomain factor-localization of gene regulatory enhancer regions to a subnuclear structure, that serves as an underlying mechanism where an enhancer-bound homeodomain factor effectively activates developmental gene transcriptional programs

Profil protéine Matrin 3 (MATR3)

Profil protéine

This locus encodes a nuclear matrix protein. Mutations at this locus have been associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts with an upstream locus have been described. Related pseuodgenes have been defined on chr1 and chrX.

Gene names and symbols associated with Matrin 3 Protéines (MATR3)

  • matrin 3 (MATR3)
  • matrin 3 (Matr3)
  • matrin 3 S homeolog (matr3.S)
  • matrin 3 (matr3)
  • 1110061A14Rik Protéine
  • 2810017I02Rik Protéine
  • AI841759 Protéine
  • AW555618 Protéine
  • D030046F20Rik Protéine
  • DKFZp459A057 Protéine
  • DKFZp459A162 Protéine
  • DKFZp459F0515 Protéine
  • DKFZp469A1933 Protéine
  • KIAA0723 Protéine
  • LOC100232255 Protéine
  • MATR3 Protéine
  • matrin-3 Protéine
  • MGC79524 Protéine
  • mKIAA0723 Protéine
  • MPD2 Protéine
  • P130/MAT3 Protéine
  • VCPDM Protéine

Protein level used designations for Matrin 3 Protéines (MATR3)

matrin-3 , vocal cord and pharyngeal weakness with distal myopathy , nuclear scaffold protein P130/MAT3 , matrin 3

9782 Homo sapiens
17184 Mus musculus
29150 Rattus norvegicus
373948 Gallus gallus
444209 Xenopus laevis
448495 Xenopus (Silurana) tropicalis
474700 Canis lupus familiaris
505129 Bos taurus
100173554 Pongo abelii
100232255 Taeniopygia guttata
100347887 Oryctolagus cuniculus
100521716 Sus scrofa
100568449 Pan troglodytes
100568450 Macaca mulatta
100568451 Callithrix jacchus
100591205 Nomascus leucogenys
100062181 Equus caballus
100730852 Cavia porcellus
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