Matrix Metallopeptidase 11 (Stromelysin 3) Protéines (MMP11)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. De plus, nous expédions MMP11 Anticorps (156) et MMP11 Kits (22) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MMP11 4320 P24347
MMP11 17385 Q02853
MMP11 25481 Q499S5
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Top MMP11 Protéines sur anticorps-enligne.fr

Showing 9 out of 12 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Détails
Escherichia coli (E. coli) Rat His tag,S tag 100 μg 15 to 18 Days
$864.00
Détails
Escherichia coli (E. coli) Humain His-GST 10% SDS-PAGE stained with Coomassie Blue (CB) and peptide fingerprinting by MALDI-TOF mass spectrometry 50 μg 6 to 9 Days
$402.73
Détails
Escherichia coli (E. coli) Humain His tag 100 μg 15 to 18 Days
$560.00
Détails
Escherichia coli (E. coli) Souris His tag   100 μg 15 to 18 Days
$672.00
Détails
Levure Rat His tag   1 mg 60 to 71 Days
$3,076.33
Détails
Levure Xenopus laevis His tag   1 mg 60 to 71 Days
$3,081.83
Détails
Escherichia coli (E. coli) Humain His-GST 50 μg 11 to 12 Days
$516.00
Détails

MMP11 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human
,
Mouse (Murine) ,

Rat (Rattus) ,
,

Plus protéines pour Matrix Metallopeptidase 11 (Stromelysin 3) (MMP11) partenaires d'interaction

Human Matrix Metallopeptidase 11 (Stromelysin 3) (MMP11) interaction partners

  1. High MMP11 expression is associated with Pancreatic Cancer.

  2. The expression of MMP-11 was increased and more heterogeneous in metastatic specimens compared to non-metastatic breast cancer samples.

  3. We believe that genetic variations in the MMP-11 gene may help to predict early-stage Hepatocellular carcinoma and act as reliable biomarkers for Hepatocellular carcinoma progression

  4. In this study, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has been used for the first time to investigate the distribution of MMP-11 in human breast cancer tissues in order to show a possible correlation between cancerous and healthy samples, by differential proteomics and using such differences for possible cancer diagnosis and/or prognosis.

  5. Authors evaluated the expression of known targets of miR-125a and found that sirtuin-7, matrix metalloproteinase-11, and c-Raf were up-regulated in tumor tissue by 2.2-, 3-, and 1.7-fold, respectively. Overall, these data support a tumor suppressor role for miR-125a.

  6. Results revealed that MMP-11 high expression in oral squamous cell carcinoma (OSCC) samples can predict the progression, especially lymph node metastasis, and the survival of OSCC patients.

  7. A new prognostic model for HR-/HER2+ breast cancer based on the expression of MMP11 and CD2 was developed and the distant metastasis-free survival for patients in the high-risk group according to our model was significantly lower than that for those in the low-risk group.

  8. HMGA1 and MMP-11 may play a key role in the proliferation and progression of skin tumors in humans.

  9. These results demonstrated that miR-145 has an inhibitory role in TNBC malignancy by targeting MMP11 and Rab27a, which might be potential therapeutic and diagnostic targets for TNBC.

  10. the data demonstrate that miR125a5p functions as a tumor suppressor gene and serves an important role in inhibiting osteosarcoma cell migration, invasion and EMT by targeting MMP11.

  11. MMP-11 overexpression is associated with aggressive tumor phenotype and unfavorable clinical outcome in urothelial carcinomas.

  12. Our study established that high serum levels of MMP-11 are associated with poor clinical outcome and may serve as a prognostic biomarker in colon cancer patients.

  13. Overexpression of MMP-11 was discovered in sera of cancer patients compared with normal control group as well as in multiple tumor tissue specimens, such as gastric cancer, breast cancer, and pancreatic cancer. At present, some evidence supports that MMP-11 may work as a significant tumor biomarker for early detection of cancer, tumor staging, prognostic analysis, monitoring recurrence [review]

  14. Matrix metalloproteinase 11 has a role in degenerating intervertebral disc disease

  15. combined effects of the MMP-11 gene polymorphisms and environmental carcinogens are related to an increased risk for the development of OSCC and may be a predictive factor for tumor lymph node metastasis in Taiwanese with OSCC

  16. results indicated that both CD147 and MMP-11 may be involved in the progression of colorectal cancer, and they are potential prognostic factors and might become new therapeutic targets for CRC patients

  17. Our findings identified these 2 genes as a novel breast cancer biomarker gene set, which may facilitate the diagnosis and treatment in breast cancer clinical therapies.

  18. High Expression of Matrix Metalloproteinase-11 is associated with Cholangiocarcinoma.

  19. study showed that plasma level of MMP-11 may be useful for assessment of the disease progression, especially lymph node metastasis, in patients with OSCC

  20. MMP-14 function might represent one critical regulatory mechanism to control the extent of pericellular MMP-11 bioavailability and protect cells from excessive/inappropriate MMP-11 function.

Mouse (Murine) Matrix Metallopeptidase 11 (Stromelysin 3) (MMP11) interaction partners

  1. Strikingly, MMP11 overexpression protects against type 2 diabetes while Mmp11-/- mice exhibit hallmarks of metabolic syndrome.

  2. Results show that MMP-11 has a paracrine function during mammary gland development that might be harnessed to promote tumor progression, exposing a new link between development and malignancy.

  3. point-out the paradoxical role of MMP11 in favoring the onset and growth of lung metastases but limiting lung foci number, and inhibiting the cancer cell dissemination to other organs

  4. investigation of a potential role of MMP-11 in adipose tissue development

  5. The increased levels of ST-3 in the thymus may be due to the presence of macrophages responsible for clearance of apoptotic cells

  6. downregulated by deglycosylation of CD147 in hepatocarcinoma cells

  7. These data together provide compelling evidence into the function of MMP-11 and suggest that MMP-11 act as a tumor lymphatic metastasis-associated gene.

  8. These findings reveal that the tumor biological marker CD147 functionally mediates MMP-11, VEGF-A expression and tumor lymphatic metastasis.

  9. Mmp11 exhibits collagenolytic function against collagen VI under normal conditions.

  10. Our study describes the identification of MMP11 as a novel broadly expressed tumor associated antigen as target candidate for cancer immunotherapy.

Xenopus laevis Matrix Metallopeptidase 11 (Stromelysin 3) (MMP11) interaction partners

  1. Transgenic tadpoles were prepared with an elastase promoter driving either the ST3 gene or the constitutively active form of Notch (IC).

  2. analysis of substrate specificity for stromelysin-3: alpha1-PI is unlikely to be a physiological substrate

  3. ST3 regulates cell fate and tissue morphogenesis through direct or indirect extracellular matrix remodeling

  4. Laminin receptor precursor cleavage by ST3 plays a role in both physiological and pathological processes.

  5. thyroid hormone regulation of Xenopus laevis Stromelysin-3 is mediated by a DNA element in the first intron

  6. Mutational analysis of the cleavage of the cancer-associated laminin receptor by stromelysin-3 reveals the contribution of flanking sequences to site recognition and cleavage efficiency.

  7. ST3 expression, in the absence of T3 hormone, caused significant muscle cell death in the tail of premetamorphic transgenic tadpoles

Profil protéine MMP11

Profil protéine

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.

Gene names and symbols associated with MMP11

  • matrix metallopeptidase 11 (MMP11)
  • matrix metallopeptidase 11 (Mmp11)
  • matrix metallopeptidase 11 L homeolog (mmp11.L)
  • stromelysin-3 (LOC103694874)
  • MMP-11 Protéine
  • SL-3 Protéine
  • ST3 Protéine
  • Stmy3 Protéine

Protein level used designations for MMP11

MMP-11 , stromelysin III , stromelysin-3 , SL-3 , matrix metalloproteinase 11 , matrix metalloproteinase-11 , stromelysin 3 , Matrix metalloproteinase 11 (stromelysin 3) , ST3 , gene 14 , Matrix metalloproteinase-11

GENE ID SPECIES
4320 Homo sapiens
17385 Mus musculus
100101604 Oryctolagus cuniculus
25481 Rattus norvegicus
486408 Canis lupus familiaris
100153503 Sus scrofa
539109 Bos taurus
100713229 Cavia porcellus
379501 Xenopus laevis
103694874 Rattus norvegicus
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