Matrix Metallopeptidase 12 (Macrophage Elastase) Protéines (MMP12)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. De plus, nous expédions MMP12 Anticorps (212) et MMP12 Kits (79) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MMP12 17381 P34960
MMP12 117033 Q63341
MMP12 4321 P39900
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Showing 10 out of 32 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Escherichia coli (E. coli) Lapin His tag 100 μg 15 to 18 Days
Escherichia coli (E. coli) Humain Inconjugué 100 μg 14 to 16 Days
Escherichia coli (E. coli) Humain His tag 100 μg 11 Days
Human Cells Souris His tag   50 μg 4 Days
Wheat germ Humain GST tag 10 μg 11 to 12 Days
Escherichia coli (E. coli) Rat His tag 100 μg 15 to 18 Days
Human Cells Humain His tag   10 μg 15 to 16 Days
Escherichia coli (E. coli) Humain Inconjugué SDS-PAGE analysis of Human MMP12 Protein. 100 μg 11 to 18 Days

MMP12 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine) ,

Rat (Rattus) ,

Human , ,

Plus protéines pour Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) partenaires d'interaction

Mouse (Murine) Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) interaction partners

  1. Reduced astrogliosis in Mmp12(-/-) mice was associated with a reduced density of activated/reactive microglia and a trend for a reduced density of M1 cells.

  2. MMP-12 can increase the expression of PGF by increasing early-growth response protein 1 (Egr-1) level through the activation of protease-activated receptor 1 (PAR-1). The PGF-mediated downstream signaling molecules drive caspase-3 and caspase-9-dependent apoptosis in bronchial epithelial cells.

  3. IL-3 stimulated the production of MMP12 from macrophages by a JNK- and ERK1/2-dependent AP-1 pathway, contributing to dissecting thoracic aneurysm formation.

  4. High MMP12 expression is associated with emphysema development in Chronic obstructive pulmonary disease.

  5. Extracellular and intracellular MMP12 have both unique and overlapping roles that help orchestrate the development of the adult V-SVZ stem cell niche.

  6. matrix metalloproteinase-12 was highly upregulated in microarray and multiplex data sets suggesting it may play a role in disease progression of diabetic peripheral neuropathy in mouse model.

  7. MMP-12 facilitates macrophage accumulation and activation in anti-GBM glomerulonephritis which is required for glomerular crescent formation, Bowman's capsule rupture, tubular damage and renal function decline.

  8. findings define a novel physiological function of Shp2 in TGF-beta1/MMP12-dependent emphysema, adding insights into potential etiologies for this chronic lung disorder.

  9. Mmp12 is expressed early following corneal epithelial injury with highest expression levels at 8 h after injury and lower expression levels at 4 and 8 days after injury. We investigated whether MMP12 has an effect on the rate of epithelial repair and cell migration using in vivo and in vitro scratch assays performed on WT and Mmp12(-/-) mice

  10. MMP-12 produced by macrophages infiltrating into glomeruli contributed to the degradation of collagen type IV and fibronectin.

  11. MMP12 causes arterial stiffening in mice and suggest that it functions similarly in humans.

  12. These results suggest that MMP-12 production during emphysema exacerbation results in increased mortality and disease progression.

  13. study found significant increases of MMP-3 and MMP-12 mRNA levels and MMP12 zymographic activities in response to Cryptococcus neoformans infection but not C. gattii infection

  14. The results suggest that pulmonary C fiber involvement in long-term airway inflammation and airway hyperresponsiveness occurred at least partially via modulating MMP-12, and the activation of PAR2 might be related to MMP-12 production.

  15. MMP-12 up-regulation mediated by SARM-TRIF signaling pathway contributes to IFN-gamma-independent airway inflammation and AHR post RSV infection in nude mice.

  16. MMP-12 and MMP-13 alter strain K infection in mice and play a role in inflammatory regulation by modulating cytokine levels.

  17. Post-MI, MMP-12i impaired CD44-HA interactions to suppress neutrophil apoptosis and prolong inflammation, which worsened LV function.

  18. MMP12 upregulated in regenerating motor neurons of the mouse and rat facial nucleus; findings point to a role of MMP12 in the neuronal initiation of the synaptic stripping process

  19. abnormal neuronal expression of matrix metalloproteinase-12 may contribute to axonal degeneration in Niemann-Pick type C disease

  20. the results of this study show a close correlation between vascular injury markers, Arg 1+ macrophage accumulation and fibrosis and suggest an important role of MMP-12 in regulating these processes.

Human Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) interaction partners

  1. Results confirm that patients with COPD exhibited more MMP-12 protein, and the -82G allele of SNP rs2276109 was more frequent in controls than in COPD patients group. On the other hand, no relationship between the mentioned genetic polymorphism and MMP-12 level was found. Nevertheless, the data, together with other findings, suggest that MMP-12 affects COPD development.

  2. In active human systemic lupus erythematosus, MMP12 levels were lower and IFN-gamma higher compared to treated patients or healthy individuals. Hence, macrophage proteolytic truncation of IFN-gamma attenuates classical activation of macrophages as a prelude for resolving inflammation.

  3. rs3025058 in MMP3 and rs2276109 in MMP12 might not contribute to the risk of developing rheumatic heart disease in a Han population in Southern China.

  4. Studied association of matrix metallopeptidase 12 (MMP12) -82 A>G promoter single nucleotide polymorphism (SNP) with bronchial asthma in a Bulgarian population. Results suggest the variant G allele of the MMP12 -82 A>G promoter polymorphism might considered protective for development of bronchial asthma.

  5. that MMP-12 might act as a potential target for the development of novel therapeutics of esophageal squamous cell carcinoma

  6. MMP-12 (-82A/G) polymorphisms associate with obesity risk and its severity.

  7. Significant association observed for MMP-12 (-1082 A/G) (OR 2.55; 95% CI 1.75 to 3.71) gene polymorphism and risk of ischemic stroke. [meta-analysis]

  8. Review/Meta-analysis: MMP-1 -1607 1G/2G and MMP-12 -82 A/G gene polymorphisms are associated with ischemic stroke risk.

  9. The MMP12 down regulation by increasing oxygen concentration enables temporal expression control of MMP12 and involves several mechanisms including HIF-1alpha. These findings suggest MMP12 involved in trophoblast invasion during the first trimester.

  10. In the present report, hypoxia is shown to activate a HIF-KDM3A-MMP12 signaling cascade that promotes trophoblast invasion and trophoblast-directed uterine spiral artery remodeling.

  11. The current results suggest that MMP12 rs652438 but not MMP12 rs2276109 may affect the risk for Parkinson Disease

  12. The results of this study demonstrate that the gene expression of MMP9, MMP12, TIMP1 and TIMP2 was influenced by the addition of TGF-beta1. These results may be translated to chronic venous insufficiency framework and suggest involvement of TGF-beta1 in the vein wall pathology.

  13. M4 macrophages are a possible source for HDAC9 and MMP12 expression in advanced human carotid plaques.

  14. MMP12 levels were increased in gingival tissue of periodontitis patients. MMP12-producing monocyte-derived cells also had reduced CD200R surface levels. MMP12 production by these cells was induced by CSF2, and treatment with a CD200R ligand reduced CSF2-induced MMP12 production. This novel association of the CD200/CD200R pathway with MMP12 production by monocyte-derived cells may play a key role in PD progression.

  15. G allele of MMP12 -82 A > G promoter polymorphism as a protective factor for COPD in Bulgarian population

  16. Data indicate that MMP1, MMP12 and PPARG and hsa-miR-31-5p, hsa-miR-224-5p, and hsa-miR-223-3p were able to distinguish tumors from NPT with high sensitivity and specificity.

  17. Increased levels of MMP1 and MMP12 on tumor-associated macrophages in the peripheral areas of dermatofibrosarcoma protuberance might contribute to local invasion

  18. Matrix metalloprotease (MMP) regulation was the top pathway involved in gingival aging. MMP3, MMP9, MMP12, and MMP13 were upregulated in old gingival tissues, concomitantly with interleukin-1 beta (IL1B) expression.

  19. We also found that MMP12 facilitated type I collagen induced platelet aggregation, adhesion and alpha granule secretion. Similarly, one short peptide, WYKG, facilitated type I collagen induced platelet alpha granule secretion. We conclude that platelet express MMP12 may facilitate platelet activation through shedding of CEACAM1.

  20. There were no statistically significant differences in the distribution of MMP7 -181 A/G and MMP12 -82 A/G genotype, allele, or haplotype frequencies between IRSA patients and controls, as well as patients' primary and secondary idiopathic recurrent spontaneous abortion

Rabbit Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) interaction partners

  1. Gene expression profiling performed on tissues obtained from pulmonary sarcoidosis patients identified MMP12 as a potential pathogenic mediator of lung damage and/or remodeling and may serve as a marker for this disease.

Profil protéine MMP12

Profil protéine

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Gene names and symbols associated with MMP12

  • matrix metallopeptidase 12 (MMP12)
  • matrix metallopeptidase 12 (Mmp12)
  • AV378681 Protéine
  • HME Protéine
  • ME Protéine
  • MME Protéine
  • Mmel Protéine
  • MMP-12 Protéine
  • MMP12 Protéine

Protein level used designations for MMP12

matrix metallopeptidase 12 (macrophage elastase) , matrix metalloproteinase 12 , MME , MMP-12 , macrophage elastase , macrophage metalloelastase , macrophage-metalloelastase , matrix metalloproteinase-12 , matrix metalloproteinase 12 (macrophage elastase) , macrophage metalloelastase MMP-12

451512 Pan troglodytes
17381 Mus musculus
117033 Rattus norvegicus
4321 Homo sapiens
100009559 Oryctolagus cuniculus
611789 Canis lupus familiaris
526981 Bos taurus
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