Matrix Metallopeptidase 16 (Membrane-inserted) Protéines (MMP16)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. De plus, nous expédions MMP16 Anticorps (132) et MMP16 Kits (21) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MMP16 17389 Q9WTR0
MMP16 65205 O35548
MMP16 4325 P51512
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Top MMP16 Protéines sur anticorps-enligne.fr

Showing 7 out of 10 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Escherichia coli (E. coli) Humain Inconjugué 10 μg Connectez-vous pour afficher 6 to 7 Days
$474.41
Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
$7,493.38
Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,262.31
Détails
Escherichia coli (E. coli) Humain His tag,T7 tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$816.00
Détails
Escherichia coli (E. coli) Humain Inconjugué   200 μg Connectez-vous pour afficher 6 to 7 Days
$6,938.01
Détails
Escherichia coli (E. coli) Humain Inconjugué 10 μg Connectez-vous pour afficher 11 to 12 Days
$613.33
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,246.83
Détails

MMP16 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)
,
Rat (Rattus)

Human ,
, ,

Plus protéines pour Matrix Metallopeptidase 16 (Membrane-inserted) (MMP16) partenaires d'interaction

Mouse (Murine) Matrix Metallopeptidase 16 (Membrane-inserted) (MMP16) interaction partners

  1. miR-155 contributed to the up-regulation of MMP-16, and MMP-16 further degraded aggrecan and collagen type II, leading to the dehydration and degeneration of intervertebral discs

  2. Neuronal knockdown of MT3-MMP resulted in the accumulation of NgR1 at the cell surface and reduced the accumulation of the NgR1 cleavage fragment in medium conditioned by cortical neurons

  3. Study demonstrates that MT3-MMP, is expressed in mesenchymal tissues of the skeleton and in peri-skeletal soft connective tissue; and MT3-MMP-deficient mice display growth inhibition tied to a decreased viability of mesenchymal cells in skeletal tissues.

Human Matrix Metallopeptidase 16 (Membrane-inserted) (MMP16) interaction partners

  1. Overexpression of MMP2 and MMP16 in endometrial cancerous tissues corresponded to down-regulation of miR-377, miR-382 and miR-410, while decreased expression of TIMP2 was associated with miR-200b up-regulation.

  2. MMP16 was highly expressed and correlated with poor prognosis in gastric cancer patients by promoting proliferation and invasion of gastric cancer cells

  3. Findings suggest that these MMP16 rs10090371, ADAMTS3 rs788935, TLL2 rs10882807 and MMP9 rs3918251 may be promising prognostic biomarkers for cutaneous melanoma specific survival (CMSS).

  4. the present findings indicate that MT3-MMP is down-regulated in ESCC, which correlates to lymph node metastasis and poor survival of patients with this disease.

  5. more severe intervertebral disc degeneration is correlated with higher matrix metallopeptidase 16

  6. results suggest that miR-145 functions as a tumor metastasis suppressor gene by down-regulating MMP16 and may be a potential target in osteosarcoma treatment

  7. the results support a role for MMP16 in promoting invasive properties of the meningioma tumours

  8. These results demonstrate that the MT3-MMP promoter is frequently hypermethylated in colorectal cancer and that downregulation of MT3-MMP may be important for cell migration in colorectal cancer.

  9. MMP16 is a putative indicator of adverse melanoma prognosis.

  10. Expression of MMP-16 in HTB9 and T24 cells increases following transforming growth factorbeta1 treatment.

  11. E2F1 acts as a transcriptional activator for MMPs and directly enhances MMP transcription by binding to E2F1 binding sequences in the promoter, or indirectly activates MMPs (MMP-9 and MMP-16)through enhanced Sp1 and NF-kappa B

  12. Matrix metalloproteinase 16 (MMP16) was a downstream target of miR-146b-5p.

  13. The overexpression of miR-146b-5p in glioblastoma cell lines led to MMP16 mRNA silencing, MMP2 inactivation, and the inhibition of tumour cell migration and invasion.

  14. Data show that MMP16 is regulated by miR-146a in spontaneously differentiated Caco-2 cells.

  15. MT3-MMP is a matrix-dependent modifier of the invasive tumor cell functions during melanoma progression

  16. down-regulation of most MT-MMPs is typical for prostate carcinoma; seems to occur mainly in epithelial cells

  17. Results report the structure of the catalytic domain (cd) of the membrane-type matrix metalloproteinase MT3-MMP/MMP-16 in complex with the hydroxamic acid inhibitor batimastat.

  18. MT3-MMP is not only important in matrix degradation but also may affect the function of focal adhesions through FAK cleavage.

  19. Type-3 metalloproteinases, are identified as the triggering agents that independently confer cancer cells with the ability to proteolytically efface the BM scaffolding, initiate the assembly of invasive pseudopodia, and propagate transmigration.

  20. Chondroitin-4-sulfate, which is expressed on tumour cell surface, can function to bind to pro-MMP-2 and facilitate its activation by MT3-MMP-expressing tumour cells to enhance invasion and metastasis

Profil protéine MMP16

Profil protéine

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.

Gene names and symbols associated with MMP16

  • matrix metallopeptidase 16 (Mmp16)
  • matrix metallopeptidase 16 (MMP16)
  • C8orf57 Protéine
  • MMP-X2 Protéine
  • MT-MMP2 Protéine
  • MT-MMP3 Protéine
  • Mt3-mmp Protéine
  • Mt3mmp Protéine

Protein level used designations for MMP16

MMP-16 , MT-MMP 3 , MTMMP3 , Membrane type 3-MMP , matrix metalloproteinase 16 , matrix metalloproteinase-16 , membrane-type matrix metalloproteinase 3 , membrane-type-3 matrix metalloproteinase , MT3MMP , Putative transmembrane protein C8orf57 , matrix metalloproteinase 16 (membrane-inserted) , membrane type-matrix metalloproteinase

GENE ID SPECIES
17389 Mus musculus
65205 Rattus norvegicus
4325 Homo sapiens
282886 Bos taurus
487036 Canis lupus familiaris
100153257 Sus scrofa
396116 Gallus gallus
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