anti-Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) Anticorps

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as art. De plus, nous expédions Matrix Metallopeptidase 17 (Membrane-inserted) Kits (27) et Matrix Metallopeptidase 17 (Membrane-inserted) Protéines (6) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
MMP17 23948 Q9R0S3
MMP17 288626  
MMP17 4326 Q9ULZ9
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Top anti-Matrix Metallopeptidase 17 (Membrane-inserted) Anticorps sur anticorps-enligne.fr

Showing 10 out of 104 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB 100 μL 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué ICC, IF, IHC (p), WB IHC-P Image MMP17 antibody [N2C2], Internal detects MMP17 protein at cytosol on human gastria carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human gastria carcinoma. MMP17 antibody [N2C2], Internal , dilution: 1:1500. Scale bar = 100 μm. WB Image Sample (30 ug of whole cell lysate) A: Hela 7.5% SDS PAGE antibody diluted at 1:1000 100 μL 3 to 4 Days
$466.18
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB 0.4 mL 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of extracts from A549 cells, treated with etoposide 25uM 1h, using MMP17 (Cleaved-Gln129) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Détails
Humain Lapin Inconjugué ELISA, WB 100 μL Disponible
$363.46
Détails
Humain Lapin Inconjugué ELISA, IHC, IHC (p) Human Small Intestine (formalin-fixed, paraffin-embedded) stained with MMP17 antibody ABIN214681 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-MMP17 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 to 14 Days
$484.00
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of anti-MMP17 Antibody in NCI-H460 cell line lysates (35ug/lane). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. BC = breast carcinoma; HC = hepatocarcinoma. 400 μL 2 to 3 Days
$515.63
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis in ZR-75-1 cell line lysates (35ug/lane). Western blot analysis in mouse liver tissue lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Détails
Humain Lapin Inconjugué ELISA, WB 200 μL 12 to 14 Days
$438.90
Détails
Humain Lapin Inconjugué EIA, IHC (p) 50 μg 6 to 8 Days
$495.00
Détails

anti-Matrix Metallopeptidase 17 (Membrane-inserted) Anticorps mieux référencés

  1. Human Polyclonal MMP17 Primary Antibody pour IHC (p), ELISA - ABIN545709 : Wang, Johnson, Ye, Dyer: Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain. dans The Journal of biological chemistry 2000 (PubMed)
    Show all 3 Pubmed References

Plus d’anticorps contre Matrix Metallopeptidase 17 (Membrane-inserted) partenaires d’interaction

Mouse (Murine) Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) interaction partners

  1. Mmp17-mediated osteopontin cleavage regulated vascular SMC maturation via c-JNK during aorta wall development. Mmp17 proteolytic activity regulates vascular SMC phenotype in the arterial vessel wall. Its absence predisposes to thoracic aortic aneurysm.

  2. function and expression of MT4-MMP

  3. MT4-MMP promotes lung metastasis by disturbing the tumour vessel integrity and thereby facilitating tumour cell intravasation

  4. MT1-MT4-MMP chimaeras do not undergo normal trafficking and are not correctly processed to their fully active forms and, as a consequence, they are unable to activate pro-MMP-2 at the cell surface.

Human Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) interaction partners

  1. MT4-MMP targeting may constitute a novel strategy to boost patrolling monocyte activity in early inflammation.

  2. Three forms of MT4-MMP with molecular masses of 45 kDa, 58 kDa and 69 kDa were detected. Further, we demonstrate that the 58 kDa form is the mature protein in the cell membrane, while the 69 kDa form is its precursor found in intracellular compartments.

  3. Low MT4-MMP expression is associated with erlotinib resistance in breast cancer.

  4. The MT4-MMP is internalized by the clathrin-independent carriers/GPI-enriched early endosomal compartments pathway, a mechanism that differs from that responsible for the internalization of other membrane-type MMP members.

  5. Screening of patients with inherited thoracic aortic aneurysms and dissections identified a missense mutation (R373H) in the MMP17 gene that prevented the expression of the protease in human transfected cells.

  6. A functional link between MT4-MMP and the growth factor receptor EGFR.

  7. CAV1 when found in lipid rafts does not allow the metalloproteinase MT4-MMP to localize into the lipid rafts, affecting its expression in the cell and probably its activity which is translated into the metastasis-associated activities of these cells.

  8. It identifies MT4-MMP as a key intrinsic tumor cell determinant that contributes to the elaboration of a permissive microenvironment for metastatic dissemination.

  9. MT4-MMP promotes lung metastasis by disturbing the tumour vessel integrity and thereby facilitating tumour cell intravasation

  10. The data presented here provide a new insight into the characteristics of MT4-MMP and highlight the common and distinct properties of the glycosylphosphatidylinositol-anchored membrane type-matrix metalloproteinases.

  11. Studies suggest a model of hypoxia induced metastasis through expression of HIF-1alpha, and SLUG regulation of MT4-MMP transcription.

  12. down-regulation of most MT-MMPs is typical for prostate carcinoma; seems to occur mainly in epithelial cells

  13. Data show that eosinophils constitutively express membrane type-4 matrix metalloproteinase (MT4-MMP), which is increased upon stimulation with tumor necrosis factor-alpha.

  14. MT4-MMP and the proteoglycan form of syndecan-1 have roles in ADAMTS-4 activation on the cell surface

  15. MT1-MT4-MMP chimaeras do not undergo normal trafficking and are not correctly processed to their fully active forms and, as a consequence, they are unable to activate pro-MMP-2 at the cell surface.

Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) profil antigène

Profil protéine

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage.

Gene names and symbols associated with MMP17

  • matrix metallopeptidase 17 (Mmp17) anticorps
  • matrix metallopeptidase 17 (MMP17) anticorps
  • matrix metallopeptidase 17a (mmp17a) anticorps
  • mmp17 anticorps
  • MT4-MMP anticorps
  • MT4MMP anticorps
  • MTMMP4 anticorps

Protein level used designations for MMP17

MMP-17 , MT-MMP 4 , matrix metalloproteinase 17 , matrix metalloproteinase-17 , membrane type-4 matrix metalloproteinase , membrane-type matrix metalloproteinase 4 , membrane-type-4 matrix metalloproteinase , MT4MMP , MTMMP4 , matrix metalloproteinase 17 (membrane-inserted) , matrix metallopeptidase 17 (membrane-inserted)

GENE ID SPECIES
23948 Mus musculus
288626 Rattus norvegicus
4326 Homo sapiens
570076 Danio rerio
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