Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Protéines (MMP3)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. De plus, nous expédions Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Anticorps (365) et Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Kits (158) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MMP3 4314 P08254
MMP3 17392 P28862
MMP3 171045  
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Top Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Protéines sur anticorps-enligne.fr

Showing 10 out of 54 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,370.21
Détails
HEK-293 Cells Souris Inconjugué   10 μg Connectez-vous pour afficher 10 to 12 Days
$222.28
Détails
HEK-293 Cells Humain Inconjugué   10 μg Connectez-vous pour afficher 10 to 12 Days
$222.28
Détails
Escherichia coli (E. coli) Humain Inconjugué 10 μg Connectez-vous pour afficher 6 to 7 Days
$474.41
Détails
Escherichia coli (E. coli) Humain His tag,T7 tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$717.00
Détails
Human Cells Humain His tag   50 μg Connectez-vous pour afficher 4 Days
$522.50
Détails
Escherichia coli (E. coli) Humain Inconjugué Validation with Western Blot 10 μg Connectez-vous pour afficher 8 to 11 Days
$218.90
Détails
Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$640.00
Détails
Escherichia coli (E. coli) Souris His tag,T7 tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$733.00
Détails

MMP3 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , , ,
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Mouse (Murine) ,
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Rat (Rattus) ,
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Plus protéines pour Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) partenaires d'interaction

Human Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) interaction partners

  1. BMAL1 Deficiency Contributes to Mandibular Dysplasia by Upregulating MMP3.

  2. No significant associations were observed with either MMP-2(-1306) C/T or MMP-3(-1171) 5A/6A.

  3. rs3025058 in MMP3 and rs2276109 in MMP12 might not contribute to the risk of developing rheumatic heart disease in a Han population in Southern China.

  4. study to explore the relationship between 2 polymorphisms (MMP-1-755 T/G [rs498186] and MMP-3 A/C [rs632478]) and disc degeneration; a significant association was found between the MMP-3 polymorphism and disc degeneration; the homozygote CC was associated with an increased risk of disc degeneration compared with the AA genotype

  5. Higher serum MMP-3 levels in knee osteoarthritis reflect disease "generalization".

  6. Report a positive correlation between glomerular filtration rate and MMP-3 activity in diabetic patients.

  7. The maternal and fetal MMP3 gene polymorphisms may be strong genetic markers of preeclampsia, occurring either individually or together.

  8. 2G allele of MMP-1, C allele of MMP-2 and 5A/6A genotype of MMP-3 are associated with susceptibility and disease progression of type 2 diabetic nephropathy

  9. MMP-1 genotype may accelerate the development of HIV-associated neurocognitive disorder (HAND) whereas MMP3 -1612 5A5A genotype may reduce the risk of pathogenesis of HAND.

  10. Preliminary studies indicate that baseline MMP3 and TIMP3 concentrations are associated with patient survival and disease-free time

  11. MMP-3 (Lys45Glu) polymorphisms associate with obesity risk and its severity.

  12. Data suggest that serum matrix metalloproteinase-3 (MMP-3) and the 7-joint ultrasound score (US7) scores could both effectively reflect disease activity and therapeutic responses in patients with moderate to severe rheumatoid arthritis (RA).

  13. results demonstrated that measurement of MMP-3 could become a marker of disease activity in rheumatoid arthritis patients

  14. The results indicated that the 5A allele of the MMP3 gene-promoter region could be associated with oral submucous fibrosis risk factor, but not oral squamous cell carcinoma, in an Indian population

  15. C/EBPbeta upregulation promoted tumor cell invasion in an MMP3-dependent manner in vitro and was associated with metastatic status in colorectal cancer

  16. MMP3 (and MMP-1 and MMP-2) are independently associated with markers of arterial stiffening in patients with type 1 diabetes.

  17. None of the studied polymorphisms showed statistically significant association with the risk of varicose veins of the lower extremities.

  18. A significant increase in the frequency of the MMP3-1171dupA (rs3025058) polymorphism genotype among patients with unstable angina was detected.

  19. No interaction between MMP-3 5A/6A polymorphism and the risk of recurrence in total IS patients was found. The variant 5A/6A+5A/5A genotype and the 5A allele were significantly associated with a high risk of recurrence for large-artery atherosclerosis (LAA) (multivariate-adjusted, P=0.002, 0.001, respectively), but not for small-artery occlusion and cardioembolism.

  20. The 5A allele of the MMP3-gene promoter polymorphism is a potential risk factor in the poor outcome of hemodialysis patients.

Mouse (Murine) Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) interaction partners

  1. BMAL1 Deficiency Contributes to Mandibular Dysplasia by Upregulating MMP3.

  2. Estrogen-related receptor gamma (ERRgamma) overexpression in chondrocytes directly upregulates matrix metalloproteinase (MMP)-3 and MMP13, which are known to play crucial roles in cartilage destruction in osteoarthritis (OA).

  3. MMP3 contributes to the pathogenesis of ARDS by affecting the pulmonary inflammatory response in female mice in relevant models of lung injury.

  4. endogenously secreted chemerin plays an autocrine/paracrine role in white adipose tissue, identifying chemerin as a therapeutic target to modulate adipose remodelling.

  5. Overexpression of Mmp3 in 3T3-L1 preadipocytes inhibited differentiation. High fat diet-induced obesity downregulates adipocyte MMP3 expression to trigger adipogenesis, and adipocyte TIMP4 may modulate this process to regulate hyperplastic vs. hypertrophic adipose tissue expansion, fat distribution, and metabolic health in a sex- and depot-dependent manner.

  6. Matrix metalloprotease 3 (MMP3), an endogenous neuronal activator of microglia, increased cytokine release from YAC128 microglia compared to wildtype microglia. We found elevated MMP levels in Huntington's Disease (HD) CSF, and MMP levels correlate with disease severity in HD. These data support a novel role for MMPs and microglial activation in HD pathogenesis.

  7. These results indicate that periodic induction, via use of an eye drop, of AAV-mediated secretion of MMP-3 into aqueous humour could have therapeutic potential for those cases of glaucoma that are sub-optimally responsive to conventional pressure-reducing medications.

  8. Data show that loss of loss of matrix metalloproteinase-3 (MMP-3) repressed the upregulation of the chemokines monocyte chemoattractant protein (MCP)-1 and (C-X-C motif) ligand 1 (CXCL1).

  9. Mmp3-knockout mice maintained higher arterial oxygenation compared to wild-type mice in a model of acute lung injury.

  10. NMP4 deficiency suppressed the arthritis-induced increase in bone resorption, expression of RANKL and MMP-3 mRNA.

  11. MMP-3 produced in blood vessel endothelial cells after spinal cord injury serves as an endogenous molecule for microglial activation followed by p38MAPK activation and proNGF production

  12. genetic inactivation of MMP-3 has profound effects on the structural integrity and plasticity response of the visual cortex of adult mice

  13. study found significant increases of MMP-3 and MMP-12 mRNA levels and MMP12 zymographic activities in response to Cryptococcus neoformans infection but not C. gattii infection

  14. This study demonstrates the sequential involvement of Wnt5, MMP-3, DMP-1 expression, and DMP-1 degradation products by MMP-3, in effecting IL-1beta-induced proliferation of ESC-derived odontoblast-like cells.

  15. Study suggests that MMP-3 modulates intracellular MAP kinase signaling pathway and as such, influences a molecular chaperone that regulates cytoskeletal components important for neurite outgrowth, neuronal migration and dendritic arborization

  16. Data indicate that interferon regulatory factor-8 (IRF8) regulates tumor behavior in an matrix metalloproteinase 3 (MMP3)-dependent manner.

  17. Established are novel molecular mechanisms underlying oxidative stress-mediated dopaminergic neuronal death in which MMP3 activation is a key upstream event that leads to Nox1 induction and eventual dopaminergic neuronal death.

  18. Our findings suggest that increased numbers of CD11c(+) macrophages and elevated levels of TNF-alpha and MMP-3 in AT and ST may explain the relationship between hyperlipidaemia and OA.

  19. These results demonstrated the role of MMP-3 in blood-spinal cord disruption after spinal cord injury for the first time

  20. study demonstrates that MMP-3 leads to caspase-9 activation and suggests that this occurs indirectly via a cytosolic protein, possibly involving Apaf-1

Pig (Porcine) Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) interaction partners

  1. The present study was aimed to determine the association between metalloproteinase 3 (MMP3), transforming growth factor beta 1 (TGFbeta1) and collagen type X alpha I (COL10A1) gene polymorphisms with traits related to leg weakness in pigs.

  2. the identification of MMP1 and MMP10 genes in swine is reported.

  3. contribution of MMPs to the inflammatory breakdown of the blood-CSF barrier in vitro

  4. Results indicate that leukemia inhibitory factor (LIF) and Oncostatin M increase the expression of MMP-1, MMP-3, and TIMP-1 several fold, and that their expression is reduced to basal levels in the presence of the LIF antagonist MH35-BD.

Rabbit Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) interaction partners

  1. Compromised autophagy may be related to the osteoarthritis progression; JNK and p38 MAPKs up-regulate MMP3 and down-regulate autophagy.

  2. the total content and active forms of matrix metalloproteinases (MMPs)-1, -3, and -13 was measured to assess the potential role of the mechanical environment in regulation of matrix turnover by ligament fibroblasts.

  3. chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage.

  4. Ulinastatin effectively inhibited the increased expression of MMP-2, MMP-3, and iNOS in degenerated NP cells induced by IL-1beta in vitro.

  5. Exposure to long periods of light irrespective of its characteristics leads to the increased expression of some matrix metalloprpteases.

  6. Tongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma in atherosclerotic rabbits.

Profil protéine Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3)

Profil protéine

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Gene names and symbols associated with MMP3

  • matrix metallopeptidase 3 (MMP3)
  • matrix metallopeptidase 3 (Mmp3)
  • matrix metallopeptidase 3 (stromelysin 1, progelatinase) (MMP3)
  • matrix metallopeptidase 3 L homeolog (mmp3.L)
  • chds6 Protéine
  • mmp-3 Protéine
  • mmp3 Protéine
  • MMP10 Protéine
  • mmp13 Protéine
  • sl-1 Protéine
  • SLN-1 Protéine
  • SLN1 Protéine
  • stmy Protéine
  • stmy1 Protéine
  • STR-1 Protéine
  • str1 Protéine

Protein level used designations for MMP3

matrix metalloproteinase 3 (stromelysin 1, progelatinase) , matrix metalloproteinase-3 , proteoglycanase , stromelysin-1 , transin-1 , EMS-2 , MMP-3 , SL-1 , matrix metalloproteinase 3 , progelatinase , stromelysin 1 , PTR1 protein , stromelysin , metalloproteinase 3 receptor , matrix metallopeptidase 3 (stromelysin 1, progelatinase) , matrix metallopeptidase 3 L homeolog , matrix metalloproteinase 13 (collagenase 3)

GENE ID SPECIES
4314 Homo sapiens
17392 Mus musculus
171045 Rattus norvegicus
396769 Sus scrofa
100009111 Oryctolagus cuniculus
100034195 Equus caballus
403445 Canis lupus familiaris
281309 Bos taurus
101118895 Ovis aries
446898 Xenopus laevis
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