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MNS1 encodes a protein highly similar to the mouse meiosis-specific nuclear structural 1 protein.
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MNS1 is an integral component of sperm flagella. Mice lacking MNS1 exhibit male sterility as evidenced by abnormal assembly of flagella. MNS1-deficient mice also display defects in left-right asymmetry patterning of internal organs and hydrocephalus.
This gene encodes a protein highly similar to the mouse meiosis-specific nuclear structural 1 protein. The mouse protein was shown to be expressed at the pachytene stage during spermatogenesis and may function as a nuclear skeletal protein to regulate nuclear morphology during meiosis.
meiosis-specific nuclear structural 1
, meiosis-specific nuclear structural protein 1
, spermatogenesis associated 40