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MNS1 encodes a protein highly similar to the mouse meiosis-specific nuclear structural 1 protein. De plus, nous expédions MNS1 Kits (7) et MNS1 Protéines (7) et beaucoup plus de produits pour cette protéine.
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MNS1 deficiency in humans causes laterality defects (situs inversus) and likely male infertility, and that MNS1 plays a role in the outer dynein arm-docking complex assembly.
Cloning and functional characterization of a highly similar gene in mouse.
A rat homologous protein was among the the nuclear proteins that change in abundance or form in response to prolonged hypoxia in the rat kidney fibroblasts.
Prenatal alcohol exposure Mns1(-/-) fetuses with severe eye defects also presented with craniofacial dysmorphologies characteristic of fetal alcohol syndrome and midline tissue loss in the brain, palate, and nasal septum
Compared to other embryonic tissues at this developmental stage, Mns1 expression is strongly enriched in the ventral node.
MNS1 is an integral component of sperm flagella. Mice lacking MNS1 exhibit male sterility as evidenced by abnormal assembly of flagella. MNS1-deficient mice also display defects in left-right asymmetry patterning of internal organs and hydrocephalus.
This gene encodes a protein highly similar to the mouse meiosis-specific nuclear structural 1 protein. The mouse protein was shown to be expressed at the pachytene stage during spermatogenesis and may function as a nuclear skeletal protein to regulate nuclear morphology during meiosis.
meiosis-specific nuclear structural 1
, meiosis-specific nuclear structural protein 1
, spermatogenesis associated 40