Melanoma Inhibitory Activity Family, Member 3 Protéines (MIA3)

Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. De plus, nous expédions MIA3 Anticorps (23) et MIA3 Kits (2) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MIA3 338366 Q8BI84
MIA3 375056 Q5JRA6
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Showing 2 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,797.11
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,797.11
Détails

MIA3 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human

Plus protéines pour Melanoma Inhibitory Activity Family, Member 3 (MIA3) partenaires d'interaction

Fruit Fly (Drosophila melanogaster) Melanoma Inhibitory Activity Family, Member 3 (MIA3) interaction partners

  1. PGANT4 is an O-glycosyltransferase (Montrer OGT Protéines) that functions as a regulator of secretion and secretory vesicle formation in vivo by glycosylating the essential Golgi/endoplasmic reticulum protein (Montrer PDIA3 Protéines), Tango1 and conferring protection from furin (Montrer FURIN Protéines)-mediated proteolysis

  2. identifed a mechanism for polarized basement membrane(BM)secretion in follicle cells; BM proteins are synthesized in a basal ER compartment and exported through Tango1-positive ER exit sites to basal Golgi clusters; Crag (Montrer AGAP3 Protéines) targets Rab10 (Montrer RAB10 Protéines) to structures in the basal cytoplasm, where it restricts protein delivery to the basal surface

  3. Study provides evidence that TANGO1 is an integral membrane protein localized to endoplasmic reticulum (ER) exit sites, with a luminal SH3 domain and a cytoplasmic proline-rich domain (PRD).

Mouse (Murine) Melanoma Inhibitory Activity Family, Member 3 (MIA3) interaction partners

  1. Mia3's role in protein secretion is much broader than previously realized, and it may, in fact, be required for the efficient secretion of all collagen molecules in higher organisms

  2. revealed very broad TANGO expression patterns in contrast to the highly restricted expression patterns previously determined for the other members of the MIA (Montrer MIA Protéines) gene family

Human Melanoma Inhibitory Activity Family, Member 3 (MIA3) interaction partners

  1. TANGO1/CTAGE5 receptor serves as a polyvalent template for assembly of large COPII coats.

  2. Mammalian endoplasmic reticulum exit sites are organized by TANGO1 acting as a scaffold, in cooperation with Sec16 for efficient secretion.

  3. TANGO1 is thus pivotal in concentrating procollagen VII (Montrer TH Protéines) in the lumen and recruiting ERGIC membranes on the cytoplasmic surface of the endoplasmic reticulum.

  4. TANGO (Montrer ARNT Protéines) expression was strongly associated with tumour progression, nodal metastasis, clinical stage and number of blood or lymph vessels in oral squamous cell carcinoma.

  5. We conclude that SNP rs17465637 in MIA3 is indeed a genetic risk factor for CAD across different ethnic populations including Han Chinese.

  6. results suggest a potential association of the MIA3 rs17465637 with cardiovascular disease in dyslipidemic patients with rheumatoid arthritis

  7. TANGO (Montrer ARNT Protéines) transfected cell lines revealed that TANGO (Montrer ARNT Protéines) expression reduces motility, whereas reduction of TANGO (Montrer ARNT Protéines) enhances migration.

  8. The results from this study present TANGO (Montrer ARNT Protéines) as a novel ligand for CD11c (Montrer ITGAX Protéines), regulating migratory processes of hematopoietic cells.

  9. Reduced expression of TANGO (Montrer ARNT Protéines) is associated with colon and hepatocellular carcinomas

Profil protéine MIA3

Profil protéine

Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. May participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1 (By similarity).

Gene names and symbols associated with MIA3

  • Transport and Golgi organization 1 (Tango1)
  • MIA family member 3, ER export factor (MIA3)
  • melanoma inhibitory activity family, member 3 (MIA3)
  • melanoma inhibitory activity protein 3 (LOC100055507)
  • melanoma inhibitory activity family member 3 (mia3)
  • melanoma inhibitory activity 3 (Mia3)
  • 9130229H14Rik Protéine
  • A930039G15Rik Protéine
  • ARNT Protéine
  • AU022327 Protéine
  • B230399H06Rik Protéine
  • C80126 Protéine
  • CG11098 Protéine
  • D320 Protéine
  • Dmel\\CG11098 Protéine
  • Gm1525 Protéine
  • MIA3 Protéine
  • TANGO Protéine
  • TANGO1 Protéine
  • UNQ6077 Protéine

Protein level used designations for MIA3

CG11098-PA , CG11098-PC , Tango1-PA , Tango1-PC , transport and golgi organisation 1 , transport and golgi organization 1 , melanoma inhibitory activity family, member 3 , melanoma inhibitory activity protein 3-like , melanoma inhibitory activity protein 3 , transport and Golgi organization protein 1 , C219 reactive peptide , C219-reactive peptide , TANGO1

GENE ID SPECIES
33930 Drosophila melanogaster
421337 Gallus gallus
457757 Pan troglodytes
478997 Canis lupus familiaris
704405 Macaca mulatta
100024966 Monodelphis domestica
100055507 Equus caballus
100351527 Oryctolagus cuniculus
100379945 Xenopus (Silurana) tropicalis
100450028 Pongo abelii
100479797 Ailuropoda melanoleuca
100580164 Nomascus leucogenys
338366 Mus musculus
375056 Homo sapiens
509133 Bos taurus
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