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Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. De plus, nous expédions MIA3 Anticorps (23) et et beaucoup plus de produits pour cette protéine.
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PGANT4 is an O-glycosyltransferase that functions as a regulator of secretion and secretory vesicle formation in vivo by glycosylating the essential Golgi/endoplasmic reticulum protein, Tango1 and conferring protection from furin-mediated proteolysis
identifed a mechanism for polarized basement membrane(BM)secretion in follicle cells; BM proteins are synthesized in a basal ER compartment and exported through Tango1-positive ER exit sites to basal Golgi clusters; Crag targets Rab10 to structures in the basal cytoplasm, where it restricts protein delivery to the basal surface
Study provides evidence that TANGO1 is an integral membrane protein localized to endoplasmic reticulum (ER) exit sites, with a luminal SH3 domain and a cytoplasmic proline-rich domain (PRD).
Mia3's role in protein secretion is much broader than previously realized, and it may, in fact, be required for the efficient secretion of all collagen molecules in higher organisms
revealed very broad TANGO expression patterns in contrast to the highly restricted expression patterns previously determined for the other members of the MIA gene family
ADTRP positively regulates PIK3R3 expression, which leads to activation of AKT and up-regulation of MIA3/TANGO1, thereby regulating endothelial cell functions directly relevant to atherosclerosis.
TANGO1/CTAGE5 receptor serves as a polyvalent template for assembly of large COPII coats.
Mammalian endoplasmic reticulum exit sites are organized by TANGO1 acting as a scaffold, in cooperation with Sec16 for efficient secretion.
TANGO1 is thus pivotal in concentrating procollagen VII in the lumen and recruiting ERGIC membranes on the cytoplasmic surface of the endoplasmic reticulum.
TANGO expression was strongly associated with tumour progression, nodal metastasis, clinical stage and number of blood or lymph vessels in oral squamous cell carcinoma.
We conclude that SNP rs17465637 in MIA3 is indeed a genetic risk factor for CAD across different ethnic populations including Han Chinese.
results suggest a potential association of the MIA3 rs17465637 with cardiovascular disease in dyslipidemic patients with rheumatoid arthritis
genetic polymorphism is associated with an increased risk of myocardial infarction
TANGO transfected cell lines revealed that TANGO expression reduces motility, whereas reduction of TANGO enhances migration.
The results from this study present TANGO as a novel ligand for CD11c, regulating migratory processes of hematopoietic cells.
Reduced expression of TANGO is associated with colon and hepatocellular carcinomas
Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. May participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1 (By similarity).
, transport and golgi organisation 1
, transport and golgi organization 1
, melanoma inhibitory activity family, member 3
, melanoma inhibitory activity protein 3-like
, melanoma inhibitory activity protein 3
, transport and Golgi organization protein 1
, C219 reactive peptide
, C219-reactive peptide