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The protein encoded by MIA2 is a tumor-associated antigen found in cutaneous T-cell lymphoma and several other cancers. De plus, nous expédions MIA2 Protéines (17) et MIA2 Kits (12) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal MIA2 Primary Antibody pour IHC, IHC (p) - ABIN4300739
Falk, Ramström, Eriksson, Uhlén, Wernérus, Hober: Targeted protein pullout from human tissue samples using competitive elution. dans Biotechnology journal 2011
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Human Polyclonal MIA2 Primary Antibody pour IHC, IHC (p) - ABIN4300738
Ek, Andréasson, Hober, Kampf, Pontén, Uhlén, Merz, Borrebaeck: From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies. dans Molecular & cellular proteomics : MCP 2006
TANGO1/CTAGE5 receptor serves as a polyvalent template for assembly of large COPII coats.
In this study, we identified specific and critical residues in the Sec12-binding region of cTAGE5 (E75A K76A, K89A, and S97A) and confirmed that cTAGE5-mediated Sec12 accumulation at ER exit sites is required for collagen VII secretion.
Data indicate that MIA2 represents a potential novel acute phase protein and MIA2 expression responds to liver damage in chronic liver diseases.
The novel gene MIA2 acts as a tumour suppressor in hepatocellular carcinoma.
population and bioinformatic analysis of MGEA6 P521A variation as a risk factor for Fahr's disease; genetic screen data show this mutation is very rare; bioinformatics analysis provided conflicting findings
cTAGE5 forms a complex with TANGO1 (MIA3), a previously characterized cargo receptor for collagen VII
HBx activates hepatoma cell growth and proliferation through repression of the potential tumor suppressor MIA2.
22 members of an Iranian family with basal ganglia calfication as well as 100 controls were genotyped for the C>G P521A variant of CTAGE5, but none were found.
Findings suggest that the roles of MIA2 might be based on the variety of the integrins and the subtypes of mitogen-activated protein kinase in oral carcinoma.
Sec12 recruitment to endoplasmic reticulum exit sites is organized by its direct interaction with cTAGE5, a previously characterized collagen cargo receptor component, which functions together with TANGO1 at endoplasmic reticulum exit sites.
These findings define an interaction between the common MIA2(I141M) variant and the ER stress/UPR system and specify a subgroup of PDAC patients who are more likely to benefit from adjuvant chemotherapy.
The protein encoded by this gene is a tumor-associated antigen found in cutaneous T-cell lymphoma and several other cancers. Autoantibodies against the encoded protein have been found in some cancers. Several transcript variants encoding different isoforms have been found for this gene.
cTAGE family member 5
, cutaneous T-cell lymphoma-associated antigen 5
, meningioma expressed antigen 6 (coiled-coil proline-rich)
, meningioma-expressed antigen 6/11
, protein cTAGE-5
, melanoma inhibitory activity protein 2