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associates with tyrosine-phosphorylated proteins to link the receptor with its substrate in the plasma membrane [RGD, Feb 2006].. De plus, nous expédions MAGI3 Protéines (4) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal MAGI3 Primary Antibody pour ICC, IF - ABIN4332453
Ni, Kuperwasser: Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer. dans eLife 2016
Human Polyclonal MAGI3 Primary Antibody pour WB - ABIN3071456
Wu, Dowbenko, Spencer, Laura, Lee, Gu, Lasky: Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase. dans The Journal of biological chemistry 2000
The altered mRNA isoform, called MAGI3(pPA (Montrer PPA1 Anticorps)), produces a truncated protein that acts in a dominant-negative manner to prevent full-length MAGI3 from interacting with the YAP (Montrer YAP1 Anticorps) oncoprotein, thereby relieving YAP (Montrer YAP1 Anticorps) inhibition and promoting malignant transformation of human mammary epithelial cells.
Results identify MAGI3 as a novel tumor suppressor and provide insight into the pathogenesis of glioma.
Expression levels of MAGI3 and PTEN (Montrer PTEN Anticorps) were significantly downregulated in gliomas.
MAGI-3 competes with NHERF-2 (Montrer SLC9A3R2 Anticorps) to negatively regulate LPA2 (Montrer LPAR2 Anticorps) receptor signaling in colon cancer cells.
Oncogenic human papillomavirus E6 proteins target the MAGI-2 (Montrer MAGI2 Anticorps) and MAGI-3 proteins for degradation [MAGI-2 (Montrer MAGI2 Anticorps), MAGI-3]
In epithelial cells, MAGI-3 was localized with ZO-1 (Montrer TJP1 Anticorps) and cingulin (Montrer CGN Anticorps) at tight junctions, whereas in primary cultured astrocytes it was found in E-cadherin (Montrer CDH1 Anticorps)-based cell-cell contacts and in focal adhesion sites.
These results demonstrate that MAGI-3 interacts directly with LPA(2 (Montrer LPAR2 Anticorps)) and regulates the ability of LPA(2 (Montrer LPAR2 Anticorps)) to activate Erk (Montrer EPHB2 Anticorps) and RhoA (Montrer RHOA Anticorps).
All of the E6 genes from different HPV types displayed similar abilities to mediate the degradation of both p53 (Montrer TP53 Anticorps) and MAGI-3
MAGI-3 has a role in efficient trafficking of TGFalpha to the cell surface in polarized epithelial cells.
associates with tyrosine-phosphorylated proteins to link the receptor with its substrate in the plasma membrane
, membrane-associated guanylate kinase inverted 3
, membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
, membrane-associated guanylate kinase-related (MAGI-3)
, scaffolding protein SLIPR
, scaffolding-like protein
, membrane-associated guanylate kinase-related 3