Mesencephalic Astrocyte-Derived Neurotrophic Factor Protéines (MANF)

The protein encoded by MANF is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. De plus, nous expédions MANF Anticorps (106) et MANF Kits (41) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MANF 7873 P55145
MANF 74840  
MANF 315989  
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Top MANF Protéines sur anticorps-enligne.fr

Showing 10 out of 29 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
Détails
Human Cells Humain His tag 100 μg Connectez-vous pour afficher 14 to 16 Days
$440.65
Détails
Human Cells Souris His tag 100 μg Connectez-vous pour afficher 14 to 16 Days
$440.65
Détails
Escherichia coli (E. coli) Humain His tag,T7 tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$656.00
Détails
Escherichia coli (E. coli) Humain Inconjugué Validation with Western Blot 25 μg Connectez-vous pour afficher 4 to 8 Days
$319.00
Détails
Human Cells Humain His tag   50 μg Connectez-vous pour afficher 4 Days
$385.00
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
Escherichia coli (E. coli) Humain His tag 100 μg Connectez-vous pour afficher 15 to 19 Days
$400.00
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
$888.80
Détails

MANF Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , , , ,
, , , ,
Mouse (Murine) ,

Rat (Rattus)

Plus protéines pour Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) partenaires d'interaction

Human Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) interaction partners

  1. High MANF expression is associated with hepatitis B.

  2. Single nucleotide polymorphism in MANF gene is associated with systemic lupus erythematosus.

  3. The results show that GDNF, CDNF, and MANF have divergent effects on dopaminergic neurotransmission, as well as on dopamine synthetizing and metabolizing enzymes.

  4. Our results showed MANF alleviated progressive neuronal degeneration and prevented locomotion defects

  5. the present study demonstrated that the AP-1 complex may be a novel regulator of MANF transcriptional enhancement, and that MANF is a novel downstream target of AP-1, which may indicate a novel role of AP-1 in regulating inflammatory pathways.

  6. MANF has antiapoptotic and mitogenic properties that protect pancreatic beta cells against stress-induced cell death

  7. Our data indicate that increased MANF concentrations in serum are associated with the clinical manifestation of type 1 diabetes in children, but the exact mechanism behind the increase remains elusive

  8. Sulfatide binding promotes cellular MANF uptake and cytoprotection from hypoxia-induced cell death.

  9. Serum MANF level was higher in patients with newly diagnosed prediabetes and T2 Diabetes Mellitus than in normal glucose tolerance controls. MANF appears to be associated with Matsuda Index, QUICKI and HOMA-IR in prediabetes patients.

  10. the role of two short sequence motifs within the carboxy-(C) terminal domain of MANF in its neuroprotective activity, was studied.

  11. the selective expression of MANF in splenocytes may be involved in plasma cell differentiation and immune regulation.

  12. MANF is a protein that interacts with RTN1-C

  13. We demonstrate that Armet and Creld2 are genotype-specific ER stress response proteins with substrate specificities, and that aggregation of mutant matrilin-3 is a key disease trigger in MED that could be exploited as a potential therapeutic target

  14. MANF binding to the plasma membrane also required the RTDL sequence and was inhibited with a peptide known to interact with KDELRs, suggesting MANF binds KDELRs at the surface.

  15. MANF and C-MANF protect neurons intracellularly as efficiently as Ku70.

  16. Pretreatment with adeno-associated-virus vector containing human MANF reduces the volume of cerebral infarction and facilitates behavioral recovery in experimental stroke rats.

  17. Armet is a novel secreted mediator of the adaptive pathway of unfolded protein response.

  18. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggest that it has important functions both under normal and pathological conditions in many tissue types.

  19. structures of MANF and CDNF were solved; structure explains why MANF and CDNF are bifunctional; neurotrophic activity may reside in the N-terminal domain and ER stress response in the C-terminal domain

Mouse (Murine) Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) interaction partners

  1. The cartilage-specific deletion of Manf described in this study phenocopies previously published chondrodysplasia models, further confirming that endoplasmic reticulum stress itself is sufficient to disrupt skeletal growth and thus represents a potential therapeutic target.

  2. We observed that the beneficial effect of OTX2 is non-cell autonomous, and it is at least partly mediated by unidentified trophic factors.

  3. Study shows that MANF is not only expressed in postmitotic neurons but also in mitotic neural stem cells (NSCs) in the mammalian brain, andthat MANF does not affect self-renewal capacity or proliferation of NSCs and suggest that MANF is dispensable for neurogenesis. MANF plays a significant role in neurite growth in the process of neuronal differentiation, which is likely the cause for delayed neuronal migration.

  4. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a neurotrophic factor that is secreted but also mediates the unfolded protein response acting intracellularly.

  5. MANF decreased the proinflammatory cytokines of IL-1beta, TNF-alpha, and IFN-gamma induced by LPS by regulating NF-kappaB and phosphorylation of p38-mitogen-activated protein kinases (MAPKs) pathways

  6. MANF has immune modulatory properties that are required for retinal repair in Drosophila

  7. secretion of mouse MANF and mouse CDNF is fundamentally regulated in the same manner, the variation of four C-terminal amino acids in the MANF and CDNF among species might influence their intracellular functions.

  8. MANF-deficient mice develop severe diabetes, progressive postnatal reduction of beta cell mass and chronic unfolded protein response activation.

  9. The findings of this study suggested that the age-related decline in chaperone activity affects polyglutamine protein function that is important for the viability of specific types of neurons.

  10. Secretion of MANF is regulated via COPII-mediated transport and that its C-terminus could be responsible for its retention in the endoplasmic reticulum through GRP78.

  11. The change in Armet expression lasted while the change of Mrpl51 disappeared after birth.

  12. the solution structure of ARMET

  13. ARMET is the second fully characterized ERSE-II-dependent gene and likely contributes to quality control of proteins in the endoplasmic reticulum

  14. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggest that it has important functions both under normal and pathological conditions in many tissue types.

Fruit Fly (Drosophila melanogaster) Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) interaction partners

  1. Study employed the Drosophila genetics to screen for potential interaction partners of Drosophila Manf (DmManf) in vivo; show that DmManf plays a role in the development of Drosophila wing.

  2. These data suggest a role for Manf in the regulation of Drosophila unfolded protein response.

  3. DmMANF expression in the adult brain is much wider than in the embryonic and larval stages. It is expressed in both glia and neurons including dopaminergic neurons.

  4. study offers further insights into the functional conservation between invertebrate and mammalian MANF/CDNF proteins and reveals the importance of the C-terminal domain for MANF activity in vivo

  5. role of MANF in multicellular organism development

  6. DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons.

Zebrafish Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) interaction partners

  1. These results suggest that MANF is involved in the regulation of the development of dopaminergic system in zebrafish.

Profil protéine MANF

Profil protéine

The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors\; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.

Gene names and symbols associated with MANF

  • mesencephalic astrocyte derived neurotrophic factor (MANF)
  • mesencephalic astrocyte-derived neurotrophic factor (Manf)
  • RNA binding motif protein 15B (RBM15B)
  • Mesencephalic astrocyte-derived neurotrophic factor (Manf)
  • mesencephalic astrocyte-derived neurotrophic factor (manf)
  • mesencephalic astrocyte derived neurotrophic factor (Manf)
  • mesencephalic astrocyte-derived neurotrophic factor S homeolog (manf.S)
  • 3230402M22Rik Protéine
  • AA407711 Protéine
  • AA408789 Protéine
  • AA673178 Protéine
  • anon-EST:ParkEST188 Protéine
  • armet Protéine
  • arp Protéine
  • ARP-like Protéine
  • CG7013 Protéine
  • D18Mgi17 Protéine
  • D17914 Protéine
  • Dmel\\CG7013 Protéine
  • DmMANF Protéine
  • im:6909481 Protéine
  • manf Protéine
  • RBM15B Protéine
  • zgc:153327 Protéine

Protein level used designations for MANF

arginine-rich, mutated in early stage tumors , arginine-rich protein , mesencephalic astrocyte-derived neurotrophic factor , RNA binding motif protein 15B , chromosome 3p21.1 gene sequence , CG7013-PA , Manf-PA , ARP-like , LOW QUALITY PROTEIN: mesencephalic astrocyte-derived neurotrophic factor , mesencephalic astrocyte-derived neurotrophic factor S homeolog

GENE ID SPECIES
7873 Homo sapiens
74840 Mus musculus
315989 Rattus norvegicus
540432 Bos taurus
745542 Pan troglodytes
770664 Gallus gallus
41983 Drosophila melanogaster
549179 Xenopus (Silurana) tropicalis
767691 Danio rerio
100505460 Sus scrofa
100719906 Cavia porcellus
100855747 Canis lupus familiaris
399228 Xenopus laevis
Fournisseurs de qualité sélectionnés pour MANF Protéines (MANF)
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