Mesencephalic Astrocyte-Derived Neurotrophic Factor Protéines (MANF)

Human Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) interaction partners

1. High MANF expression is associated with hepatitis B.

2. Single nucleotide polymorphism in MANF gene is associated with systemic lupus erythematosus.

3. The results show that GDNF, CDNF, and MANF have divergent effects on dopaminergic neurotransmission, as well as on dopamine synthetizing and metabolizing enzymes.

4. Our results showed MANF alleviated progressive neuronal degeneration and prevented locomotion defects

5. the present study demonstrated that the AP-1 complex may be a novel regulator of MANF transcriptional enhancement, and that MANF is a novel downstream target of AP-1, which may indicate a novel role of AP-1 in regulating inflammatory pathways.

6. MANF has antiapoptotic and mitogenic properties that protect pancreatic beta cells against stress-induced cell death

7. Our data indicate that increased MANF concentrations in serum are associated with the clinical manifestation of type 1 diabetes in children, but the exact mechanism behind the increase remains elusive

8. Sulfatide binding promotes cellular MANF uptake and cytoprotection from hypoxia-induced cell death.

9. Serum MANF level was higher in patients with newly diagnosed prediabetes and T2 Diabetes Mellitus than in normal glucose tolerance controls. MANF appears to be associated with Matsuda Index, QUICKI and HOMA-IR in prediabetes patients.

10. the role of two short sequence motifs within the carboxy-(C) terminal domain of MANF in its neuroprotective activity, was studied.

11. the selective expression of MANF in splenocytes may be involved in plasma cell differentiation and immune regulation.

12. MANF is a protein that interacts with RTN1-C

13. We demonstrate that Armet and Creld2 are genotype-specific ER stress response proteins with substrate specificities, and that aggregation of mutant matrilin-3 is a key disease trigger in MED that could be exploited as a potential therapeutic target

14. MANF binding to the plasma membrane also required the RTDL sequence and was inhibited with a peptide known to interact with KDELRs, suggesting MANF binds KDELRs at the surface.

15. MANF and C-MANF protect neurons intracellularly as efficiently as Ku70.

16. Pretreatment with adeno-associated-virus vector containing human MANF reduces the volume of cerebral infarction and facilitates behavioral recovery in experimental stroke rats.

17. Armet is a novel secreted mediator of the adaptive pathway of unfolded protein response.

18. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggest that it has important functions both under normal and pathological conditions in many tissue types.

19. structures of MANF and CDNF were solved; structure explains why MANF and CDNF are bifunctional; neurotrophic activity may reside in the N-terminal domain and ER stress response in the C-terminal domain

Mouse (Murine) Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) interaction partners

1. The cartilage-specific deletion of Manf described in this study phenocopies previously published chondrodysplasia models, further confirming that endoplasmic reticulum stress itself is sufficient to disrupt skeletal growth and thus represents a potential therapeutic target.

2. We observed that the beneficial effect of OTX2 is non-cell autonomous, and it is at least partly mediated by unidentified trophic factors.

3. Study shows that MANF is not only expressed in postmitotic neurons but also in mitotic neural stem cells (NSCs) in the mammalian brain, andthat MANF does not affect self-renewal capacity or proliferation of NSCs and suggest that MANF is dispensable for neurogenesis. MANF plays a significant role in neurite growth in the process of neuronal differentiation, which is likely the cause for delayed neuronal migration.

4. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a neurotrophic factor that is secreted but also mediates the unfolded protein response acting intracellularly.

5. MANF decreased the proinflammatory cytokines of IL-1beta, TNF-alpha, and IFN-gamma induced by LPS by regulating NF-kappaB and phosphorylation of p38-mitogen-activated protein kinases (MAPKs) pathways

6. MANF has immune modulatory properties that are required for retinal repair in Drosophila

7. secretion of mouse MANF and mouse CDNF is fundamentally regulated in the same manner, the variation of four C-terminal amino acids in the MANF and CDNF among species might influence their intracellular functions.

8. MANF-deficient mice develop severe diabetes, progressive postnatal reduction of beta cell mass and chronic unfolded protein response activation.

9. The findings of this study suggested that the age-related decline in chaperone activity affects polyglutamine protein function that is important for the viability of specific types of neurons.

10. Secretion of MANF is regulated via COPII-mediated transport and that its C-terminus could be responsible for its retention in the endoplasmic reticulum through GRP78.

11. The change in Armet expression lasted while the change of Mrpl51 disappeared after birth.

12. the solution structure of ARMET

13. ARMET is the second fully characterized ERSE-II-dependent gene and likely contributes to quality control of proteins in the endoplasmic reticulum

14. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggest that it has important functions both under normal and pathological conditions in many tissue types.

Fruit Fly (Drosophila melanogaster) Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) interaction partners

1. Study employed the Drosophila genetics to screen for potential interaction partners of Drosophila Manf (DmManf) in vivo; show that DmManf plays a role in the development of Drosophila wing.

2. These data suggest a role for Manf in the regulation of Drosophila unfolded protein response.

3. DmMANF expression in the adult brain is much wider than in the embryonic and larval stages. It is expressed in both glia and neurons including dopaminergic neurons.

4. study offers further insights into the functional conservation between invertebrate and mammalian MANF/CDNF proteins and reveals the importance of the C-terminal domain for MANF activity in vivo

5. role of MANF in multicellular organism development

6. DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons.

Zebrafish Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) interaction partners

1. These results suggest that MANF is involved in the regulation of the development of dopaminergic system in zebrafish.