anti-Mesoderm Posterior 2 Homolog (Mouse) (Mesp2) Anticorps

Mouse (Murine) Mesoderm Posterior 2 Homolog (Mouse) (Mesp2) interaction partners

1. Studies indicate that mesodermal posterior 1 (Mesp1 (Montrer MESP1 Anticorps)) and mesodermal posterior 2 (Mesp2) double-knockout embryos exhibited defective development of the embryonic mesoderm.

2. conclusion was supported by analyses of Mesp2 KO and Ripply1/2 double KO embryos lacking rostral and caudal (Montrer CAD Anticorps) properties, respectively

3. current observations of the spatiotemporal disorder of vertebral organogenesis in the Mesp2-null mice provide further insight into the pathogenesis of SCDO and STDO, and the physiological development of the axial skeleton

4. Data demonstrate that Mesp2 is a novel component involved in the suppression of Notch (Montrer NOTCH1 Anticorps) target genes.

5. Data propose a novel function of Notch (Montrer NOTCH1 Anticorps) signaling, in which a progressive oscillating wave of Notch (Montrer NOTCH1 Anticorps) activity is translated into the rostral-caudal (Montrer CAD Anticorps) polarity of a somite by regulating Mesp2 expression in the anterior presomitic mesoderm.

6. A bHLH-type transcription factor, Mesp2, plays an essential role in somite segmentation in mice.

7. Data describe the genetic interactions between Dll1 (Montrer DLL1 Anticorps), Dll3 (Montrer DLL3 Anticorps), Mesp2 and Psen1 (Montrer PSEN1 Anticorps), and the roles of Dll1 (Montrer DLL1 Anticorps)- and Dll3 (Montrer DLL3 Anticorps)-Notch (Montrer NOTCH1 Anticorps) pathways, with or without Psen1 (Montrer PSEN1 Anticorps), in rostrocaudal patterning.

8. Mesp2 is responsible for the rostro-caudal (Montrer CAD Anticorps) patterning process itself in the anterior presomitic mesoderm, via cellular interaction.

9. developmental protein "wavefront" is generated by suppression of Notch (Montrer NOTCH1 Anticorps) activity by mesoderm posterior 2 (Mesp2) through induction of the lunatic fringe (Montrer LFNG Anticorps) gene (Lfng (Montrer LFNG Anticorps))

10. Tbx6 (Montrer TBX6 Anticorps) directly binds to the Mesp2 gene upstream region and mediates Notch (Montrer NOTCH1 Anticorps) signaling, and subsequent Mesp2 transcription, in the anterior presomitic mesoderm.

Human Mesoderm Posterior 2 Homolog (Mouse) (Mesp2) interaction partners

1. The present study firstly provided experimental evidence supporting the concept that a MESP1 (Montrer MESP1 Anticorps) lossoffunction mutation may contribute to the development of double outlet right ventricle in humans, which presents a significant insight into the molecular pathogenesis of congenital heart disease.

2. results suggest that pathologic variants in MESP1 (Montrer MESP1 Anticorps) may contribute to the development of congenital heart disease (CHD (Montrer CHDH Anticorps)) and that additional protein partners and downstream targets could likewise contribute to the wide range of causes for CHD (Montrer CHDH Anticorps)

3. The MESP1 (Montrer MESP1 Anticorps)-NKX2-5 (Montrer NKX2-5 Anticorps) hESC reporter line allows us to identify molecular cues crucial for specification and expansion of human cardiac mesoderm and early progenitors and their differentiation to specific cardiovascular derivatives.

4. MESP1 (Montrer MESP1 Anticorps) SNPs are associated with congenital heart disease in patients and altered transcription in vitro.

5. Transcription factors ETS2 (Montrer ETS2 Anticorps) and MESP1 (Montrer MESP1 Anticorps) transdifferentiate human dermal fibroblasts into cardiac progenitors.

6. MESP2, HES7 and DUSP6 genes may not be involved in the etiopathogenesis of sporadic and non-syndromic CS in Chinese Han population.

7. Mutated MESP2 causes spondylocostal dysostosis

8. Mesp1 (Montrer MESP1 Anticorps) is down-regulated in the later stages of development by increasing levels of Mesp2 in the wild-type embryo.

9. findings suggest a founder-effect mutation in the MESP2 gene as a major cause of the classical Puerto Rican form of spondylothoracic dysostosis/Jarcho-Levin syndrome

10. MesP1 (Montrer MESP1 Anticorps) drives vertebrate cardiovascular differentiation through Dkk-1 (Montrer DKK1 Anticorps)-mediated blockade of Wnt (Montrer WNT2 Anticorps)-signalling