Metastasis Associated in Colon Cancer 1 Protéines (MACC1)

MACC1 is a key regulator of the hepatocyte growth factor (HGF\; MIM 142409)-HGF receptor (HGFR, or MET\; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. De plus, nous expédions MACC1 Anticorps (50) et MACC1 Kits (12) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MACC1 346389 Q6ZN28
Souris MACC1 MACC1 238455  
Rat MACC1 MACC1 314539  
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Showing 3 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
Détails
Escherichia coli (E. coli) Humain His tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$784.00
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
$888.80
Détails

MACC1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
,

Plus protéines pour Metastasis Associated in Colon Cancer 1 (MACC1) partenaires d'interaction

Human Metastasis Associated in Colon Cancer 1 (MACC1) interaction partners

  1. MACC1 knockdown effectively inhibited cell proliferation and promoted apoptosis of lung adenocarcinoma cells by regulating the beta-catenin pathway.

  2. Our results suggest that MACC1 expression might be a biomarker for poor prognosis in individual epithelial ovarian cancer patients

  3. expression of MACC1-AS1 in gastric cancer tissues is linked to poor prognosis and promotes malignant phenotype upon cancer cells. MACC1-AS1 is elevated under metabolic stress and facilitates metabolic plasticity by promoting MACC1 expression through mRNA stabilization.

  4. The expressions of AXIN and MACC1 proteins are related to the prognosis of gastric carcinoma patients, and are involved in the invasion and metastasis of gastric carcinoma.

  5. Expression levels of MACC1, CD44, Twist1, and KiSS-1 are related to duration of overall survival among patients with colonic adenocarcinoma.

  6. Authors validated that metastasis associated in colon cancer-1 (MACC1) is a novel target of miR-598 in GBM. Restoring MACC1 expression reversed the inhibitory effects of miR-598 overexpression on GBM cells.

  7. These results demonstrated that miR485 may perform its tumor suppressive function in cervical cancer by directly targeting MACC1 and inhibiting the Met/AKT signaling pathway. Therefore, the miR485/MACC1 axis may be a novel and effective therapeutic target in cervical cancer.

  8. MACC1 is an independent prognostic marker in patients with small invasive lung adenocarcinoma after complete surgical resection. Differential outcomes are associated with MACC1 expression level.

  9. MACC1 and c-Myc are highly expressed in serum and tumor tissues of EC patients. Both are correlated with TNM stage, primary infiltration, and lymph node or distal metastasis.

  10. The results of this study found that MACC1 protein expression in tumor tissue is significantly prognostic for shorter disease-free survival.

  11. miR-338-3p/MACC1/MAPK regulatory pathway play an important role in the progression of cervical cancer.

  12. this study found that upregulation of MACC1 in ESCC was associated with lymph node metastasis of patients, and MACC1 regulated ESCC cell proliferation, apoptosis, migration and invasion mainly through AMPK-ULK1 induced autophagy

  13. MACC1 overexpression is associated with poor survival rates, regional invasion and lymph-node metastasis [meta-analysis]

  14. MACC1 expression stratifies colon cancer patients with unfavorable pMMR status. Stage II colon cancer patients with pMMR/MACC1-low tumors have a similar favorable prognosis to those with dMMR with potential implications for the role of adjuvant therapy

  15. coexistence of high MACC1 and low NM23-H1 expression and tumor budding was associated with short overall survival

  16. YB-1 promoted lung adenocarcinoma growth and progression in vitro and in vivo through directly binding to the MACC1 promoter and enhancing MACC1/c-Met pathway.

  17. Serum metastasis-associated in colon cancer-1 (MACC1) levels were higher in breast cancer patients than patients with benign disease or healthy volunteers.

  18. restoration of MACC1 expression could abrogate the anti-metastatic effects of miR-944 on colorectal cancer (CRC)cells with enhanced cell migration and invasion. MACC1/Met/AKT signaling may be implicated with the function of miR-944 in CRC cells. Altogether, miR-944 potentially act as a prognostic predictor and a drug-target for CRC patients.

  19. Data suggest that the miR-497/MACC1 axis mediated the effect of XIST on GC cell growth.

  20. these findings highlight the pivotal role of miR-218 in various aspects of MACC1 expression regulation and MACC1-mediated colorectal cancer progression

Mouse (Murine) Metastasis Associated in Colon Cancer 1 (MACC1) interaction partners

  1. Data suggest a critical role for MACC1 in lymphatic dissemination of GC, providing evidence that MACC1 upregulated VEGF-C/VEGF-D secretion to promote lymphangiogenesis via c-Met signaling.

  2. HGF, MACC1 and C-met genes involve into malignant cervical tumors occurrence, development and prognosis, and might become potential molecular target therapy site of cervical cancer

  3. MACC1 has a role in colorectal cancer and can be used for imaging in xenografts

  4. MACC1 will be useful for the identification of poor prognosis subjects with colorectal cancer and is a promising new target for intervention in metastasis formation.

Profil protéine MACC1

Profil protéine

MACC1 is a key regulator of the hepatocyte growth factor (HGF\; MIM 142409)-HGF receptor (HGFR, or MET\; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009

Gene names and symbols associated with MACC1

  • MACC1, MET transcriptional regulator (MACC1)
  • metastasis associated in colon cancer 1 (Macc1)
  • MACC1, MET transcriptional regulator (Macc1)
  • 7a5 Protéine
  • 4732474O15Rik Protéine
  • Gm267 Protéine
  • RGD1309838 Protéine
  • SH3BP4L Protéine

Protein level used designations for MACC1

SH3 domain-containing protein 7a5 , metastasis-associated in colon cancer protein 1 , putative binding protein 7a5

GENE ID SPECIES
346389 Homo sapiens
238455 Mus musculus
314539 Rattus norvegicus
521867 Bos taurus
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