Methyltransferase Like 3 Protéines (METTL3)

METTL3 encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. De plus, nous expédions METTL3 Anticorps (31) et METTL3 Kits (2) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
METTL3 56339 Q86U44
METTL3 56335 Q8C3P7
Rat METTL3 METTL3 361035  
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Showing 4 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Wheat germ Humain GST tag 10 μg 11 to 12 Days
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days

METTL3 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine)

Plus protéines pour Methyltransferase Like 3 (METTL3) partenaires d'interaction

Human Methyltransferase Like 3 (METTL3) interaction partners

  1. We conclude that METTL3 plays a vital role in many steps of RNA processing and orchestrates successful execution of oncogenic pathways in glioma stem-like cells .

  2. METTL3 was up-regulated in the breast cancer tissue and cells. And, METTL3 could install the methylation of Bcl-2 and promote its translation, thereby regulating the proliferation and apoptosis of breast cancer.

  3. METTL3 expression is elevated in bladder cancer.MYC, AFF4, RELA and IKBKB are functionally important target genes of METTL3 in bladder cancer.

  4. METTL3 might inhibit the LPS-induced inflammatory response of human dental pulp cells by regulating alternative splicing of MyD88.

  5. we found that METTL3 interacted with viral RNA-dependent RNA polymerase 3D and induced enhanced sumoylation and ubiquitination of the 3D polymerase that boosted viral replication. Taken together, our findings demonstrated that the host m6A modification complex interacts with viral proteins to modulate EV71 replication.

  6. An important mechanism for SUMOylation of METTL3 regulating its m6A RNA methyltransferase activity.Lysine 177/211/212/215 are major SUMOylation-sites of METTL3.METTL3 role in tumorigenesis.

  7. Study demonstrates that oncogenic miR-25 in pancreatic duct epithelial cells can be excessively maturated by cigarette smoke condensate (CSC) via enhanced N(6)-methyladenosine modification that is mediated by NF-kappaB associated protein NKAP. This modification is catalyzed by overexpressed METTL3 due to hypomethylation of the METTL3 promoter also caused by CSC.

  8. METTL3-eIF3h interaction is required for enhanced translation, formation of densely packed polyribosomes and oncogenic transformation; findings uncover a mechanism of translation control that is based on mRNA looping and identify METTL3-eIF3h as a potential therapeutic target for patients with cancer

  9. METTL3 acts as an oncogene in myeloid leukemia MOLM13 cells by upregulating MYC expression.

  10. Findings suggest that METTL3 plays very important oncogenic roles in ovarian carcinoma development and/or aggressiveness by stimulating AXL translation and EMT.

  11. Data show that hepatitis B X-interacting protein (HBXIP) modulated Methyltransferase-like 3 (METTL3) by inhibiting miRNA let-7g, which down-regulated the expression of METTL3 by targeting its 3'UTR.

  12. Study reports the importance of m6A modification in glioma stem-like cells and uncovers METTL3 as a potential molecular target in glioblastoma therapy.

  13. The role of METTL3 in pancreatic cancer cells drug resistance and radiation resistance.METTL3 was associated with mitogen-activated protein kinase cascades, ubiquitin-dependent process and RNA splicing and regulation of cellular process.

  14. METTL3 is soluble and inactive while the catalytic center of METTL14 is degenerated and thus also inactive. In addition, the C-terminal RGG repeats of METTL14 are required for METTL3/14 activity by contributing to RNA substrate binding.

  15. data define METTL3 as a regulator of a chromatin-based pathway that is necessary for maintenance of the leukaemic state and identify this enzyme as a potential therapeutic target for acute myeloid leukaemia

  16. methylation at m6A by METTL3/METTL14 facilitates the methylation of m5C by NSUN2, and vice versa. NSUN2-mediated m5C and METTL3/METTL14-mediated m6A methylation synergistically enhance p21 expression at the translational level

  17. loss of METTL3 leads to increased levels of phosphorylated AKT, which contributes to the differentiation-promoting effects of METTL3 depletion. Overall, these results provide a rationale for the therapeutic targeting of METTL3 in myeloid leukemia

  18. The structure reveals the heterodimeric architecture of the complex and donor substrate binding by METTL3. Structure-guided mutagenesis indicates that METTL3 is the catalytic subunit of the complex, whereas METTL14 has a degenerate active site and plays non-catalytic roles in maintaining complex integrity and substrate RNA binding.

  19. For the methylation of adenosine in RNA, Mettl3 is the catalytically active subunit, while Mettl14 plays a structural role critical for substrate recognition.

  20. METTL3 enhances mRNA translation through an interaction with the translation initiation machinery in lung adenocarcinoma cells.

Mouse (Murine) Methyltransferase Like 3 (METTL3) interaction partners

  1. METTL3-mediated methylation of mRNA on N(6)-adenosines as a dynamic modification that is enhanced in response to hypertrophic stimuli and is necessary for a normal hypertrophic response in cardiomyocytes.

  2. The depleting METTL3 in mouse hippocampus reduces memory consolidation ability, yet unimpaired learning outcomes can be achieved if adequate training was given or the m(6)A methyltransferase function of METTL3 was restored.

  3. deleting Mettl3 from myeloid cells using Lysm-cre did not impact myeloid cell number or function. RNA sequencing revealed 2,073 genes with significant m(6)A modifications in HSCs. Myc was identified as a direct target of m(6)A in HSCs. Mettl3-deficient HSCs failed to upregulate MYC expression following stimulation to differentiate and enforced expression of Myc rescued differentiation defects of Mettl3-deficient HSCs.

  4. WTAP, coupled with METTL3 and METTL14, is increased and distributed in nucleus by the induction of adipogenesis dependently on RNA in vitro knockdown of each of these three proteins leads to cell cycle arrest and impaired adipogenesis.

  5. Mettl3-mediated mRNA m(6)A methylation promotes dendritic cell activation.

  6. analysis established that METTL3-mediated N6-methyladenosine participates in cerebellar development by controlling mRNA stability of genes related to cerebellar development and apoptosis and by regulating alternative splicing of pre-mRNAs of synapse-associated genes.

  7. Conditional knockout of Mettl3 in bone marrow mesenchymal stem cells (MSCs) induces pathological features of osteoporosis in mice. Mettl3 loss-of-function results in impaired bone formation, incompetent osteogenic differentiation potential and increased marrow adiposity. Moreover, Mettl3 overexpression in MSCs protects the mice from estrogen deficiency-induced osteoporosis.

  8. The data showed that Mettl3 is required for MyoD mRNA expression in proliferative myoblasts.

  9. Mettl3 was essential for male fertility and spermatogenesis.

  10. Combined deletion of Mettl3 and Mettl14 in advanced germ cells with Stra8-GFPCre disrupts spermiogenesis, whereas mice with single deletion of either Mettl3 or Mettl14 in advanced germ cells show normal spermatogenesis.

  11. data define METTL3 as a regulator of a chromatin-based pathway that is necessary for maintenance of the leukaemic state and identify this enzyme as a potential therapeutic target for acute myeloid leukaemia

  12. genetic inactivation impaired embryonic stem cells differentiation

  13. this study identifies Mettl3, an N(6)-methyladenosine (m(6)A) transferase, as a regulator for terminating murine naive pluripotency.

Profil protéine METTL3

Profil protéine

This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.

Gene names and symbols associated with METTL3

  • methyltransferase like 3 (mettl3)
  • methyltransferase like 3 L homeolog (mettl3.L)
  • methyltransferase like 3 (METTL3)
  • methyltransferase like 3 (Mettl3)
  • methyltransferase-like 3 (Mettl3)
  • 2310024F18Rik Protéine
  • fj82g07 Protéine
  • IME4 Protéine
  • M6A Protéine
  • MT-A70 Protéine
  • Spo8 Protéine
  • wu:fj82g07 Protéine
  • zgc:77093 Protéine

Protein level used designations for METTL3

N6-adenosine-methyltransferase 70 kDa subunit , adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase , mRNA m(6)A methyltransferase , methyltransferase-like protein 3 , MT-A70 , m6a methyltransferase , methyltransferase-like 3

100004398 Danio rerio
414662 Xenopus laevis
56339 Homo sapiens
475404 Canis lupus familiaris
540339 Bos taurus
56335 Mus musculus
361035 Rattus norvegicus
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