Methyltransferase Like 3 Protéines (METTL3)

METTL3 encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. De plus, nous expédions METTL3 Anticorps (33) et METTL3 Kits (4) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
METTL3 56339 Q86U44
METTL3 56335 Q8C3P7
Rat METTL3 METTL3 361035  
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Showing 4 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,626.73
Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,626.73
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
$888.80
Détails

METTL3 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine)

Plus protéines pour Methyltransferase Like 3 (METTL3) partenaires d'interaction

Human Methyltransferase Like 3 (METTL3) interaction partners

  1. METTL3 acts as an oncogene in myeloid leukemia MOLM13 cells by upregulating MYC expression.

  2. Findings suggest that METTL3 plays very important oncogenic roles in ovarian carcinoma development and/or aggressiveness by stimulating AXL translation and EMT.

  3. Data show that hepatitis B X-interacting protein (HBXIP) modulated Methyltransferase-like 3 (METTL3) by inhibiting miRNA let-7g, which down-regulated the expression of METTL3 by targeting its 3'UTR.

  4. Study reports the importance of m6A modification in glioma stem-like cells and uncovers METTL3 as a potential molecular target in glioblastoma therapy.

  5. The role of METTL3 in pancreatic cancer cells drug resistance and radiation resistance.METTL3 was associated with mitogen-activated protein kinase cascades, ubiquitin-dependent process and RNA splicing and regulation of cellular process.

  6. METTL3 is soluble and inactive while the catalytic center of METTL14 is degenerated and thus also inactive. In addition, the C-terminal RGG repeats of METTL14 are required for METTL3/14 activity by contributing to RNA substrate binding.

  7. data define METTL3 as a regulator of a chromatin-based pathway that is necessary for maintenance of the leukaemic state and identify this enzyme as a potential therapeutic target for acute myeloid leukaemia

  8. methylation at m6A by METTL3/METTL14 facilitates the methylation of m5C by NSUN2, and vice versa. NSUN2-mediated m5C and METTL3/METTL14-mediated m6A methylation synergistically enhance p21 expression at the translational level

  9. loss of METTL3 leads to increased levels of phosphorylated AKT, which contributes to the differentiation-promoting effects of METTL3 depletion. Overall, these results provide a rationale for the therapeutic targeting of METTL3 in myeloid leukemia

  10. The structure reveals the heterodimeric architecture of the complex and donor substrate binding by METTL3. Structure-guided mutagenesis indicates that METTL3 is the catalytic subunit of the complex, whereas METTL14 has a degenerate active site and plays non-catalytic roles in maintaining complex integrity and substrate RNA binding.

  11. For the methylation of adenosine in RNA, Mettl3 is the catalytically active subunit, while Mettl14 plays a structural role critical for substrate recognition.

  12. METTL3 enhances mRNA translation through an interaction with the translation initiation machinery in lung adenocarcinoma cells.

  13. miR-33a can attenuatenon-small-cell lung carcinoma cells proliferation via targeting to the 3'-untranslated region of METTL3 mRNA.

  14. Structure of the METTL3-METTL14 complex

  15. genetic inactivation impaired embryonic stem cells differentiation

  16. Study identifies m(6)A methylation sites on many clock gene transcripts and shows that specific inhibition of m(6)A methylation by silencing of the m(6)A methylase Mettl3 is sufficient to elicit circadian period elongation and RNA processing delay.

Mouse (Murine) Methyltransferase Like 3 (METTL3) interaction partners

  1. The data showed that Mettl3 is required for MyoD mRNA expression in proliferative myoblasts.

  2. Mettl3 was essential for male fertility and spermatogenesis.

  3. Combined deletion of Mettl3 and Mettl14 in advanced germ cells with Stra8-GFPCre disrupts spermiogenesis, whereas mice with single deletion of either Mettl3 or Mettl14 in advanced germ cells show normal spermatogenesis.

  4. data define METTL3 as a regulator of a chromatin-based pathway that is necessary for maintenance of the leukaemic state and identify this enzyme as a potential therapeutic target for acute myeloid leukaemia

  5. genetic inactivation impaired embryonic stem cells differentiation

  6. this study identifies Mettl3, an N(6)-methyladenosine (m(6)A) transferase, as a regulator for terminating murine naive pluripotency.

Profil protéine METTL3

Profil protéine

This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.

Gene names and symbols associated with METTL3

  • methyltransferase like 3 (mettl3)
  • methyltransferase like 3 L homeolog (mettl3.L)
  • methyltransferase like 3 (METTL3)
  • methyltransferase like 3 (Mettl3)
  • methyltransferase-like 3 (Mettl3)
  • 2310024F18Rik Protéine
  • fj82g07 Protéine
  • IME4 Protéine
  • M6A Protéine
  • MT-A70 Protéine
  • Spo8 Protéine
  • wu:fj82g07 Protéine
  • zgc:77093 Protéine

Protein level used designations for METTL3

N6-adenosine-methyltransferase 70 kDa subunit , adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase , mRNA m(6)A methyltransferase , methyltransferase-like protein 3 , MT-A70 , m6a methyltransferase , methyltransferase-like 3

GENE ID SPECIES
100004398 Danio rerio
414662 Xenopus laevis
56339 Homo sapiens
475404 Canis lupus familiaris
540339 Bos taurus
56335 Mus musculus
361035 Rattus norvegicus
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