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MEX3C encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. De plus, nous expédions MEX3C Anticorps (50) et et beaucoup plus de produits pour cette protéine.
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Data suggest that KH1 and HK2 domains of MEX3C bind with high affinity to MRE10, a 10-mer RNA (5prime-CAGAGUUUAG-3prime) containing an eight-nucleotide MEX3C recognition element motif (AGAGUUUA); 3prime-untranslated region of HLA-A2 mRNA contains such a high affinity binding site for KH domains of MEX3C. (MEX3C = mex-3 RNA binding family member C; HLA-A2 = HLA class I histocompatibility antigen, A-2 alpha chain)
associates with cytoplasmic deadenylation complexes and ubiquitinates CNOT7
The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation
In combination sibling-pair linkage analysis and case-control association studies of chromosome 18, RKHD2 is found to contribute to the genetic susceptibility of essential hypertension.
MEX3C associates with the endolysosomal compartment through an endocytosis-like process. siRNA-mediated inhibition of the MEX3C or AP-2 complex substantially decreased exosomal but not cellular microRNA miR-451a expression
The specific expression of this long MEX3C isoform in oocytes and its ability to enhance FOS mRNA nuclear export and stability all suggest that MEX3C(659AA) is an RNA-binding protein that preserves maternal FOS mRNA in oocytes.
Data indicate that Mex3c mutation significantly increases physical activity.
MEX3C is required for cytokine production after infection with RNA viruses that are detected by RIG-I.
Mex3c mutation caused leanness in both heterozygous and homozygous transgenic mice, as well as a more beneficial blood glucose and lipid profile in homozygous transgenic mice, in both sexes; data show Mex3c is involved in energy balance regulation
data suggest that MEX3C plays an important role in enhancing the translation of Igf1 mRNA directly or indirectly and promoting postnatal growth
This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension.
RNA-binding protein MEX3C
, ring finger and KH domain containing 2
, mex-3 homolog C (C. elegans)
, mex-3 homolog C
, RING finger and KH domain-containing protein 2
, RING finger protein 194
, RNA-binding E3 ubiquitin-protein ligase MEX3C