Microtubule Associated Tumor Suppressor 1 Protéines (MTUS1)

MTUS1 encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. De plus, nous expédions MTUS1 Anticorps (65) et MTUS1 Kits (8) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MTUS1 57509 Q9ULD2
MTUS1 102103 Q5HZI1
MTUS1 306487 Q6IMY1
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Showing 8 out of 11 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
Escherichia coli (E. coli) Humain Inconjugué SDS-PAGE analysis of Human MTUS1 Protein. 100 μg Connectez-vous pour afficher 11 to 18 Days
$639.61
Détails
Escherichia coli (E. coli) Rat Inconjugué SDS-PAGE analysis of Rat MTUS1 Protein. 100 μg Connectez-vous pour afficher 11 to 18 Days
$668.03
Détails
Escherichia coli (E. coli) Souris Inconjugué SDS-PAGE analysis of Mouse MTUS1 Protein. 100 μg Connectez-vous pour afficher 11 to 18 Days
$682.25
Détails
Levure Poisson Zèbre His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,232.17
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,232.17
Détails

MTUS1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
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Mouse (Murine) ,
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Rat (Rattus) ,
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Plus protéines pour Microtubule Associated Tumor Suppressor 1 (MTUS1) partenaires d'interaction

Human Microtubule Associated Tumor Suppressor 1 (MTUS1) interaction partners

  1. The N-terminal coiled-coil domain of MTUS1 interacted with the mitochondrial membrane proteins.

  2. MTUS1 is not only involved in the formation and progression of human cancers but also involved in the complex pathological conditions such as cardiac hypertrophy, atherosclerosis, and SLE-like lymphoproliferative diseases. Several molecular mechanisms such as proliferation, differentiation, DNA repair, inflammation, vascular remodeling and senescence appear to be tightly regulated by the MTUS1-encoded proteins.

  3. findings have provided the first clues regarding the roles of miR-19a/b, which appear to function as oncomirs in lung cancer by downregulating MTUS1.

  4. angiotensin II type 2 receptor-interacting protein 3a presents potential in suppressing the proliferation and aggressiveness of ovarian carcinoma cells through the high mobility group AT-hook 2-mediated extracellular signal-regulated kinase/epithelial-to-mesenchymal transition signal pathway.

  5. Our findings showed that MTUS1 regulates the p38 MAPK-mediated cytokine production in ECs. MTUS1 gene probably plays a protective role against pro-inflammatory response of ECs.

  6. Deregulated microRNA (miRNA) expression has been shown to be involved in the pathogenesis of several types of cancers including colorectal cancer (CRC). MTUS1 targeting miRNAs may play key roles in the development of CRC by downregulating tumor suppressor MTUS1.

  7. Study reports differential expression of MTUS1 and its regulatory miRNAs in breast cancer and fibroadenoma tissues; among MTUS1 targeting miRNAs, miR-183-5p was overexpressed in breast cancer and down-regulated in fibroadenoma tissues; expression levels of MTUS1 and miR-183-5p correlated with clinical parameters. In particular, MTUS1 was found to be diminished and miR-183-5p was elevated with advancing stage.

  8. We propose a novel mechanism by which ATIP3-EB1 interaction indirectly reduces the kinetics of EB1 exchange on its recognition site, thereby accounting for negative regulation of microtubule dynamic instability

  9. Our studies confirm that MTUS1 plays an important role in the progression of salivary adenoid cystic carcinoma , and may serve as a biomarker or therapeutic target for patients with salivary adenoid cystic carcinoma

  10. Data identifies MTUS1 as a tumour suppressor gene in cultured bladder cancer cells and in advanced bladder tumours.

  11. The present data suggested MTUS1 as a potential tumor suppressor in gastric cancer and might lead to a better understanding of gastric carcinogenesis.

  12. analysis of a functional ATIP3 domain that associates with microtubules and recapitulates the effects of ATIP3 on microtubule dynamics, cell proliferation, and migration in breast cancer

  13. MTUS1 plays major roles in the progression of oral tongue squamous cell carcinoma.

  14. ATIP3 is a novel microtubule-associated protein related to MTUS1, with a role in invasiveness and progression of breast neoplasms

  15. Results in human prostate cancer cell lines demonstrate the presence of ATIP in both cell lines examined.

  16. MTUS1 could be involved in the loss of proliferative control in human colon cancer

  17. identified a tumor suppressor gene named MTSG1 at chromosome 8p21.3-22, encoding a mitochondrial protein, controlling cellular proliferation

  18. Results identify ATIP1 (angiotensin II AT2 receptor-interacting protein) as a novel early component of growth inhibitory signaling cascade

Mouse (Murine) Microtubule Associated Tumor Suppressor 1 (MTUS1) interaction partners

  1. important role in AT2 receptor-mediated PPARgamma activation

  2. ATIPs seem to be mainly involved in the developmental regulation of the cardiovascular system and may act in different AT2-dependent and -independent manners.

  3. ATIP1 could exert anti-inflammatory effects in adipose tissue via macrophage polarization associated with improvement of insulin resistance.

  4. analysis of a functional ATIP3 domain that associates with microtubules and recapitulates the effects of ATIP3 on microtubule dynamics, cell proliferation, and migration in breast cancer

  5. Reports the first generation of a MTUS1 KO mouse, developing spontaneous heart hypertrophy and increased cell proliferation, confirming once more the anti-proliferative effect of MTUS1, and a SLE-like lymphoproliferative disease.

  6. ATIP3 is a novel microtubule-associated protein related to MTUS1, with a role in invasiveness and progression of breast neoplasms

  7. Results identify ATIP1 (angiotensin II AT2 receptor-interacting protein) as a novel early component of growth inhibitory signaling cascade.

  8. ATIP1 plays an important role in cuff-induced vascular remodeling in mice

Xenopus laevis Microtubule Associated Tumor Suppressor 1 (MTUS1) interaction partners

  1. ICIS and Aurora B coregulate the microtubule depolymerase Kif2a.

Profil protéine MTUS1

Profil protéine

This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.

Gene names and symbols associated with MTUS1

  • microtubule associated scaffold protein 1 (MTUS1)
  • mitochondrial tumor suppressor 1 (Mtus1)
  • microtubule associated scaffold protein 1 (Mtus1)
  • microtubule associated scaffold protein 1 L homeolog (mtus1.L)
  • microtubule associated tumor suppressor 1 (MTUS1)
  • microtubule associated tumor suppressor 1a (mtus1a)
  • AI481402 Protéine
  • ATBP Protéine
  • ATBP135 Protéine
  • ATIP Protéine
  • Atip1 Protéine
  • Atip3b Protéine
  • ATIP4 Protéine
  • B430010I23Rik Protéine
  • B430305I03Rik Protéine
  • C85752 Protéine
  • Cctsg1-440 Protéine
  • fa17d11 Protéine
  • fbx27 Protéine
  • ICIS Protéine
  • MD44 Protéine
  • mKIAA1288 Protéine
  • MP44 Protéine
  • Mtsg1 Protéine
  • wu:fa17d11 Protéine
  • wu:fi18f08 Protéine
  • zgc:154168 Protéine

Protein level used designations for MTUS1

AT2 receptor-binding protein , AT2 receptor-interacting protein , AT2R binding protein , angiotensin-II type 2 receptor-interacting protein , erythroid differentiation-related , microtubule-associated tumor suppressor 1 , mitochondrial tumor suppressor gene 1 , transcription factor MTSG1 , AT2 receptor-interacting protein 1 , angiotensin II AT2 receptor-interacting protein 1 , coiled-coiled tumor suppressor gene 1 protein , coiled-coiled tumor supressor gene 1 , microtubule-associated tumor suppressor 1 homolog , mitochondrial tumor suppressor 1 homolog , growth factor inhibitor , mitochondrial tumor suppressor 1 , F-box protein 27 , ICIS , inner centromere Kin-I stimulator , inner centromere KinI stimulator , microtubule-associated tumor suppressor 1 homolog A , microtubule associated tumor suppressor 1

GENE ID SPECIES
57509 Homo sapiens
102103 Mus musculus
515016 Bos taurus
306487 Rattus norvegicus
398697 Xenopus laevis
422729 Gallus gallus
475615 Canis lupus familiaris
100053906 Equus caballus
563853 Danio rerio
100713005 Cavia porcellus
100346261 Oryctolagus cuniculus
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