Mitochondrial Transcription Termination Factor Protéines (MTERF)

MTERF encodes a mitochondrial transcription termination factor. De plus, nous expédions Mitochondrial Transcription Termination Factor Anticorps (51) et Mitochondrial Transcription Termination Factor Kits (3) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MTERF 85261 Q9EPI8
MTERF 7978 Q99551
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Showing 4 out of 6 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,869.04
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
Escherichia coli (E. coli) Humain Inconjugué SDS-PAGE analysis of Human MTERF Protein. 100 μg Connectez-vous pour afficher 11 to 18 Days
$582.75
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,911.33
Détails

MTERF Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Rat (Rattus)

Human , ,
, ,

Plus protéines pour Mitochondrial Transcription Termination Factor (MTERF) partenaires d'interaction

Mouse (Murine) Mitochondrial Transcription Termination Factor (MTERF) interaction partners

  1. MTERF1 does not regulate heavy-strand transcription, but rather acts to block transcription on the opposite strand of mtDNA to prevent transcription interference at the light-strand promoter.

Human Mitochondrial Transcription Termination Factor (MTERF) interaction partners

  1. MTERF1 has the ability to accommodate alternate active conformations.

  2. It has been demonstrated that MTERF1 arrests mitochondrial DNA (mtDNA) replication with distinct polarity whereby MTERF1 acts as a directional contra-helicase, blocking mtDNA unwinding by the mitochondrial helicase TWINKLE.

  3. Studies indicate that the structure of the mitochondrial transcription termination factor (MTERF1) provides insight into the mechanism of binding, recognition of the termination sequence and the conformational changes involved in mediating termination.

  4. Single nucleotide polymorphism in MTERF gene is associated with epithelial ovarian cancer.

  5. Data show that mTERF protein levels materially affect the amount of readthrough transcription on the antisense strand of mtDNA, whilst the effects on sense-strand transcripts are complex, and suggest the influence of compensatory mechanisms.

  6. Presented are the crystal structures of human mitochondrial regulator MTERF, a transcription termination factor also implicated in replication pausing, in complex with double-stranded DNA oligonucleotides containing the tRNA(Leu)(UUR) gene sequence.

  7. The structure indicates that upon sequence recognition MTERF1 unwinds the DNA molecule, promoting eversion of three nucleotides.

  8. mTERF mRNA levels were higher in elite athletes compared with moderately active subjects

  9. mTERF exists in mitochondria in two forms, an active monomer and an inactive large size complex

  10. monomeric human mTERF is fully active in its non-phosphorylated form and that the protein does not require additional cellular factors to terminate mitochondrial transcription in vitro

Fruit Fly (Drosophila melanogaster) Mitochondrial Transcription Termination Factor (MTERF) interaction partners

  1. mTerf5 knockdown led to enhanced replication pausing at mTTF binding sites, a decrease in fragile replication intermediates containing single-stranded segments, and the disappearance of species containing segments of RNA/DNA hybrid

  2. The first ever-obtained evidence for an in vivo role of an animal mitochondrial transcription termination factor.

  3. DmTTF might play multiple roles in the mtDNA transcription process, for which different levels of the protein with respect to mtRNApol are required.

Profil protéine Mitochondrial Transcription Termination Factor (MTERF)

Profil protéine

This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome\; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding.

Gene names and symbols associated with MTERF

  • mitochondrial transcription termination factor 1 (MTERF1)
  • mitochondrial transcription termination factor (MTERF)
  • mitochondrial transcription termination factor 1 (Mterf1)
  • mitochondrial transcription termination factor 1 (mterf1)
  • mitochondrial transcription termination factor (mTTF)
  • BG:DS01068.4 Protéine
  • CG18124 Protéine
  • Dmel\\CG18124 Protéine
  • DmTTF Protéine
  • DS01068.4 Protéine
  • Mterf Protéine

Protein level used designations for MTERF

mitochondrial transcription termination factor , Transcription termination factor, mitochondrial , mitochondrial transcription termination factor 1 , transcription termination factor, mitochondrial , CG18124-PA , mTTF-PA , transcription termination factor 1, mitochondrial

GENE ID SPECIES
703725 Macaca mulatta
472439 Pan troglodytes
100172789 Pongo abelii
85261 Rattus norvegicus
522191 Bos taurus
549783 Xenopus (Silurana) tropicalis
7978 Homo sapiens
34837 Drosophila melanogaster
100355865 Oryctolagus cuniculus
100716389 Cavia porcellus
100516386 Sus scrofa
100684053 Canis lupus familiaris
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