Mitochondrially Encoded NADH Dehydrogenase 4 Protéines (MT-ND4)

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. De plus, nous expédions Mitochondrially Encoded NADH Dehydrogenase 4 Anticorps (7) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MT-ND4 4538 P03905
MT-ND4 17719 P03911
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,355.45
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Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
$7,626.01
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Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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MT-ND4 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour Mitochondrially Encoded NADH Dehydrogenase 4 (MT-ND4) partenaires d'interaction

Human Mitochondrially Encoded NADH Dehydrogenase 4 (MT-ND4) interaction partners

  1. This review focuses on the role of mitochondrial genes in causing LHON and therapeutics available for treating the disease. A systematic search has been adopted in various databases using the keywords "LHON," "mitochondria," "ND1," "ND4," "ND6," and "therapy" and the following review on mitochondrial genetics.

  2. A missense mutation, m.11778G>A (p.R340H), in the ND4 gene was identified in eight patients and three asymptomatic carriers, even though the incidence of this has been considered low in Chinese population.

  3. MT-ND4 and MT-TL1 (Montrer TNFSF15 Protéines) genetic variation might be associated with male infertility in Chinese patients.

  4. this paper identified m.11240C4T in ND4 as a novel mitochondrial disease-related mtDNA mutation in Leigh syndrome.

  5. We identified a genetic association between the MT-ND4 11719 A/G polymorphism and Ulcerative Colitis in the subgroup of males. The male-specific association indicates differences between males and females concerning the impact of mitochondrial gene polymorphisms on the development of Ulcerative Colitis.

  6. The molecular study of a family with one member with Leber hereditary optic neuropathy found the mitochondrial mutation m.11778G>A in MT-ND4.

  7. the ND4 gene is the hot spot for mutations associated with Leber's hereditary optic neuropathy

  8. Three mutations were significantly related to the presence of epilepsy. These mutations were found at the 8502, 11994, and 13,231 bp of mtDNA, which resulted in amino acid changes at the MT-ATP-8 (Montrer MT-ATP8 Protéines), MT-ND4 and MT-ND5 (Montrer MT-ND5 Protéines) genes.

  9. Expression of WT human ND4 in cells with the G11778A mutation in ND4 led to restoration of defective ATP synthesis.

  10. altered activity of complex III modulates the phenotypic manifestation of Leber's hereditary optic neuropathy-associated ND4 G11778A mutation

Mouse (Murine) Mitochondrially Encoded NADH Dehydrogenase 4 (MT-ND4) interaction partners

  1. Cybrid mice showed normal respiratory function whether or not their mtDNA possessed the A11181G mutation of the mt-Nd4 gene, suggesting that the this mutation is not responsible for respiration defects found in SAMP8 mice.

Arabidopsis thaliana Mitochondrially Encoded NADH Dehydrogenase 4 (MT-ND4) interaction partners

  1. Data indicate that SLOW GROWTH 4 (SLO4) is a mitochondrial pentatricopeptide repeat (PPR) protein that is involved in editing NADH dehydrogenase subunit 4 (nad4), possibly required for the efficient splicing of NADH dehydrogenase subunit 2 (nad2) intron1.

  2. The data supports a model for MTSF1 functioning in which its association with the last nucleotides of the nad4 3' untranslated region stabilizes nad4 mRNA.

Profil protéine Mitochondrially Encoded NADH Dehydrogenase 4 (MT-ND4)

Profil protéine

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Gene names and symbols associated with MT-ND4

  • NADH dehydrogenase, subunit 4 (complex I) (ND4)
  • NADH dehydrogenase subunit 4 (ND4)
  • NADH dehydrogenase subunit 4 (nad4)
  • NADH dehydrogenase subunit 4 (NAD4)
  • NADH dehydrogenasesubunit 4 (nad4)
  • MTND4 Protéine
  • NADH4 Protéine

Protein level used designations for MT-ND4

NADH dehydrogenase subunit 4

GENE ID SPECIES
4538 Homo sapiens
17719 Mus musculus
3283886 Bos taurus
804483 Canis lupus familiaris
807643 Gallus gallus
808510 Sus scrofa
808225 Oryctolagus cuniculus
2565705 Caenorhabditis elegans
814596 Arabidopsis thaliana
807666 Ascaris suum
807960 Locusta migratoria
802562 Candida albicans SC5314
808213 Branchiostoma lanceolatum
1734028 Acanthamoeba castellanii
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