Mitofusin 1 Protéines (MFN1)

The protein encoded by MFN1 is a mediator of mitochondrial fusion. De plus, nous expédions Mitofusin 1 Anticorps (129) et Mitofusin 1 Kits (8) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MFN1 55669 Q8IWA4
MFN1 67414 Q811U4
Rat MFN1 MFN1 192647 Q8R4Z9
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Top Mitofusin 1 Protéines sur anticorps-enligne.fr

Showing 8 out of 13 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,370.21
Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,626.73
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,370.21
Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 60 to 65 Days
$7,506.65
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
Détails
Escherichia coli (E. coli) Humain Inconjugué SDS-PAGE analysis of Human MFN1 Protein. 100 μg Connectez-vous pour afficher 11 to 18 Days
$582.75
Détails
Escherichia coli (E. coli) Souris Inconjugué SDS-PAGE analysis of Mouse MFN1 Protein. 100 μg Connectez-vous pour afficher 11 to 18 Days
$625.39
Détails

MFN1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , ,
, , , ,
Mouse (Murine) ,
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Plus protéines pour Mitofusin 1 (MFN1) partenaires d'interaction

Cow (Bovine) Mitofusin 1 (MFN1) interaction partners

  1. The results showed that high level of Mfn1 expression significantly improved the embryo development rates by increasing ATP level and Deltapsim, while reducing H(2)O(2) generation.

Human Mitofusin 1 (MFN1) interaction partners

  1. The results lead to a revised understanding of Mfn 1 as single-spanning outer membrane proteins with an Nout-Cin orientation, providing functional insight into the IMS contribution to redox-regulated fusion events.

  2. The results may suggest that TP53BP1 and MFN1 frameshift mutations and their intratumoral heterogeneity (ITH) could contribute to cancer development by inhibiting the TSG activities.

  3. The results show that a metabolic shift from glycolysis in young to mitochondrial respiration in old normal human fibroblasts occurs during chronological lifespan, and MFN1 and OPA1 regulate this process.

  4. mitochondria elongation under hypoxic condition is regulated through SIRT1-mediated MFN1 deacetylation and accumulation.

  5. Regulation of Mfn1 by MGRN1 and the proteasome modulates mitochondrial fusion.

  6. SLC25A46 is a new component in mitochondrial dynamics that serves as a regulator for MFN1/2 oligomerization.

  7. MFN1-positive expression could be seen mainly in ganglion cells after 1 week of minus lens intervention, and with time extension, more and more positive cells appeared in the rod-cone cell and bipolar cell layer, and this phenomenon could not be found in the normal control eyes.

  8. crystal structures of engineered human MFN1 containing the GTPase domain and a helical domain during different stages of GTP hydrolysis; mechanistic model for MFN1-mediated mitochondrial tethering is proposed; results shed light on the molecular basis of mitochondrial fusion and mitofusin-related human neuromuscular disorders

  9. These results suggest that MFN tethers apposing membranes, likely through nucleotide-dependent dimerization.

  10. Improper transcriptional (in)activation of mitofusin-1 and dynamin-related protein 1 during early in vitro embryo development is associated with a decrease in mitochondrial membrane potential and with embryo fragmentation.

  11. A fine balance of Mfn1 levels is maintained by MARCH5-mediated quality control on acetylated Mfn1.

  12. miR-19b targets 3'UTR sequences of Mfn1 genes inhibit the expression of Mfn1

  13. In a amyotrophic lateral sclerosis transgenic mouse model, Mfn1 is significantly increased in spinal cord.

  14. A novel role for the endoplasmic reticulum-associated Gp78 ubiquitin ligase and the Mfn1 mitochondrial fusion factor in mitophagy.

  15. Knock-out of mitofusin protein Mfn1 increased the frequency of mitochondrial fission with increased lifetime of unpaired events whereas deletion of both Mfn1 and Mfn2 resulted in an instable dynamics.

  16. These results collectively suggest a role for Mfn1 in regulating the activation of Bax on the outer mitochondrial membrane in a GTPase-dependent manner.

  17. mitochondrial dynamics, particularly those mediated by the mitofusins, play a role in endothelial cell function and viability.

  18. Patterned Purkinje cell degeneration is dependent on caspase activation, leading to the marked decrease of mitofusion 1 in the transgenic Harlequin cerebellum.

  19. Our data supports a model whereby the translocation of parkin to damaged mitochondria induces the degradation of mitofusin 1 leading to impaired mitochondrial fusion

  20. The impact of mutations in endogenous PINK1 and Parkin on the ubiquitination of mitochondrial fusion and fission factors and the mitochondrial network structure, was investigated.

Mouse (Murine) Mitofusin 1 (MFN1) interaction partners

  1. data posit MFN1-mediated mitochondrial dynamics in POMC neurons as an intrinsic nutrient-sensing mechanism and unveil an unrecognized link between this subset of neurons and insulin release.

  2. These results highlight the crucial role of MFN1 in maintaining the competency of the STING pathway.

  3. Despite apparent mitochondrial dysfunction, hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction due to impaired mitochondria/sarcoplasmic reticulum tethering.

  4. We found that mouse embryonic fibroblasts lacking Mfn2 have altered lipid droplet morphology. However, triacylglycerol biosynthesis was not dependent on ER-mitochondrial tethering mediated by mitofusins. Lastly, Mfn2 does not have a role in adipocyte differentiation.

  5. MFN1 deficiency leads to defects in mitochondrial activity and male infertility.

  6. Report exposes a novel role for Shh in regulating mitochondrial dynamics and rescue the metabolic profile of tumor cells through regulation of mitofusin 1 and 2.

  7. Ablating Mfn1 eliminates the cardiac-related lethality of Mff knockout mice.

  8. Data suggest that mitochondrial fusion and fission events are regulated by four GTPases: Mfn1, Mfn2, OPA1 (optic atrophy 1 protein), and Drp1 (dynamin 1-like protein). [REVIEW]

  9. Authors present evidence that metabolically challenged mitochondria undergo active fusion to suppress oxidative stress. In response to glucose starvation, mitofusin 1 (MFN1) becomes associated with the protein deacetylase HDAC6.

  10. These findings suggest that mitochondrial impairment is a very early event in Alzheimer disease pathogenesis and abnormal expression of Mfn1 and Mfn2 caused by excessive intracellular Abeta is the possible molecular mechanism.

  11. Data identify MFN1 as an ERK target to modulate mitochondrial shape and apoptosis.

  12. A fine balance of Mfn1 levels is maintained by MARCH5-mediated quality control on acetylated Mfn1.

  13. Mitochondrial shape governs BAX-induced membrane permeabilization and apoptosis via Mfn1.

  14. Data unmask an important role for mitochondrial dynamics governed by Mfn1 and Mfn2 in Agrp neurons in central regulation of whole-body energy metabolism.

  15. Our findings establish that Mfn-1 and Mfn-2 are essential in mediating mitochondrial remodeling during postnatal cardiac development, a time of dramatic transitions in the bioenergetics and growth of the heart.

  16. Data suggest that Mfn-1 deletion in cardiomyocytes confers protection against reactive oxygen species-induced mitochondrial dysfunction.

  17. Patterned Purkinje cell degeneration is dependent on caspase activation, leading to the marked decrease of mitofusion 1 in the Harlequin cerebellum.

  18. Double Mfn-null cells show neither outer nor inner membrane fusion, while mitochondria in OPA1-null cells contain multiple matrix compartments bounded together by a single outer membrane, consistent with uncoupling of outer versus inner membrane fusion.

  19. results suggest that the heptad repeat region (HR2) of mfn1 functions as a mitochondrial tether before fusion

  20. OPA1, Mfn1 and Mfn2 have roles in mitochondrial fusion, cell growth, mitochondrial membrane potential, and cellular respiration

Profil protéine Mitofusin 1 (MFN1)

Profil protéine

The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.

Gene names and symbols associated with Mitofusin 1 Protéines (MFN1)

  • mitofusin 1b (mfn1b)
  • mitofusin 1 (MFN1)
  • mitofusin 1 S homeolog (mfn1.S)
  • mitofusin 1 (mfn1)
  • mitofusin 1 (Mfn1)
  • 2310002F04Rik Protéine
  • 6330416C07Rik Protéine
  • D3Ertd265e Protéine
  • Fzo1b Protéine
  • hfzo1 Protéine
  • hfzo2 Protéine
  • HR2 Protéine
  • MFN1 Protéine
  • MFN2 Protéine
  • mitofusin-1 Protéine
  • mKIAA4032 Protéine
  • zgc:66150 Protéine

Protein level used designations for Mitofusin 1 Protéines (MFN1)

mitofusin 1 , mitofusin-1 , mitofusin 2 , mitofusin-1-like , fzo homolog , mitochondrial transmembrane GTPase FZO-2 , mitochondrial transmembrane GTPase Fzo-1 , putative transmembrane GTPase , transmembrane GTPase MFN1 , mitochondrial transmembrane GTPase FZO1B

GENE ID SPECIES
393620 Danio rerio
424973 Gallus gallus
460861 Pan troglodytes
488086 Canis lupus familiaris
495314 Xenopus laevis
515180 Bos taurus
548943 Xenopus (Silurana) tropicalis
100394906 Callithrix jacchus
100586660 Nomascus leucogenys
55669 Homo sapiens
67414 Mus musculus
192647 Rattus norvegicus
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