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MAPK8IP1 encodes a regulator of the pancreatic beta-cell function. De plus, nous expédions MAPK8IP1 Protéines (4) et et beaucoup plus de produits pour cette protéine.
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These interactions are required for SRC (Montrer SRC Anticorps)-induced activation of VAV (Montrer VAV1 Anticorps) and the subsequent engagement of a JIP1-tethered JNK (Montrer MAPK8 Anticorps) signaling module.
Phosphorylation of KLC1 (Montrer KLC1 Anticorps) at Thr466 increased in aged brains, and JIP1 binding to kinesin-1 decreased, suggesting that APP (Montrer APP Anticorps) transport is impaired by aging. Authors conclude that phosphorylation of KLC1 (Montrer KLC1 Anticorps) at Thr466 regulates the velocity of transport of APP (Montrer APP Anticorps) by kinesin-1 by modulating its interaction with JIP1b.
It mediates Alzheimer-disease like pathologies in AICD-Tg mice and that JNK (Montrer MAPK8 Anticorps) signaling may contribute to amyloid-independent mechanisms of AD pathogenesis.
Enhanced fast-velocity and efficient high-frequency APP (Montrer APP Anticorps) anterograde transport observed in neurons are mediated by novel roles of JIP1b.
a simple yet modular mechanism for JIP1 scaffold assembly in mammals
There is a collaborative relationship between JIP1 and AKT (Montrer AKT1 Anticorps) that is required for axon growth and can be regulated by changes in neuronal activity.
identify plenty of SH3 (POSH (Montrer SH3RF1 Anticorps)) and JNK-interacting protein 1 (JIP-1) as a multiprotein scaffold network for TCR-mediated JNK1 (Montrer MAPK8 Anticorps) activation in CD8 (Montrer CD8A Anticorps)(+) T cells.
The phosphorylation of S421 of JIP1 serves as a molecular switch to regulate the direction of APP (Montrer APP Anticorps) transport in neurons.
Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 (Montrer MAP3K11 Anticorps) interaction with JIP1 scaffold protein (Montrer HOMER1 Anticorps) in cytokine-induced pancreatic beta cell death
JIP1 forms a trimetric complex with RBP-Jk (Montrer RBPJ Anticorps) and Notch1 (Montrer NOTCH1 Anticorps)-IC, prevents physical association between Notch1 (Montrer NOTCH1 Anticorps)-IC and RBP-Jk (Montrer RBPJ Anticorps), sequesters RBP-JK (Montrer RBPJ Anticorps) in the cytoplasm, and suppresses the Notch1 (Montrer NOTCH1 Anticorps) signaling pathway.
All binary complexes (KLC1 (Montrer KLC1 Anticorps):APP (Montrer APP Anticorps), KLC1 (Montrer KLC1 Anticorps):JIP1, and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 (Montrer KLC1 Anticorps) and JIP1 may take part in APP (Montrer APP Anticorps) transport in Alzheimer's disease patients.
analysis of the role of JIP1 in APP (Montrer APP Anticorps) transport; knockdown of JIP1 did not affect either amyloid precursor protein (Montrer APP Anticorps) transport or amyloid-beta peptide production
Data show that small GTPase (Montrer RACGAP1 Anticorps) RALA (Montrer rala Anticorps) regulates formation of a JIP1 (C-Jun (Montrer JUN Anticorps)-amino-terminal-interacting protein 1) scaffold complex to propagate JNK (Montrer MAPK8 Anticorps) signaling toward FOXO4 (Montrer FOXO4 Anticorps) (forkhead box O (Montrer FOXO Anticorps) transcription factor) in response to reactive oxygen species (ROS (Montrer ROS1 Anticorps)).
In resected pancreatic cancer, carriers of a minor allele for rs3824872 (MAPK8IP1) were associated with a survival advantage compared with noncarriers with an additional 2-year survival if both minor alleles were present.
Data suggest that caspase 3 (Montrer CASP3 Anticorps)-mediated cleavage of JIP1 scaffold proteins may represent an important mechanism for modulation of JNK (Montrer MAPK8 Anticorps) signalling during apoptotic cell death.
Data show that mechanical stress of urothelial cells activates in vivo JNK (Montrer MAPK8 Anticorps), as a consequence of a regulated expression of IB1/JIP-1, and that urothelial connexin 26 (Montrer GJB2 Anticorps) may be directly regulated by the AP-1 (Montrer FOSB Anticorps) complex.
results suggest that JIP (Montrer SMAD4 Anticorps)-1b may function as a protein linking the kinesin-I motor protein to the cargo receptor, APP (Montrer APP Anticorps), and that the JNK (Montrer MAPK8 Anticorps) signaling pathway may regulate the phosphorylation of this cargo protein through the JIP (Montrer SMAD4 Anticorps)-1b scaffold
JIP1 may act as an Akt1 (Montrer AKT1 Anticorps) scaffold, which regulates the enzymatic activity of Akt1 (Montrer AKT1 Anticorps) and can exert signaling effects independent of JNK (Montrer MAPK8 Anticorps) activity
JIP-1 protein may regulate kinesin-I-dependent neuronal AbetaPP transport, which controls AbetaPP processing
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
mitogen-activated protein kinase 8 interacting protein 1
, c-Jun-amino-terminal kinase-interacting protein 1-like
, C-Jun-amino-terminal kinase-interacting protein 1
, JNK MAP kinase scaffold protein 1
, JNK-interacting protein 1
, mitogen activated protein kinase 8 interacting protein 1
, mitogen-activated protein kinase 8-interacting protein 1
, protein kinase, mitogen-activated 8 interacting protein
, JIP-1-related protein
, mitogen activated protein kinase 8 interacting protein
, PRKM8 interacting protein
, islet-brain 1
, islet brain 1