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The protein encoded by MAPK8IP3 shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. De plus, nous expédions et beaucoup plus de produits pour cette protéine.
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Mouse (Murine) Polyclonal MAPK8IP3 Primary Antibody pour IHC (p), IHC - ABIN249901
Kelkar, Gupta, Dickens, Davis: Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. dans Molecular and cellular biology 2000
our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein
The crystal structure of an N-terminally truncated form of LZII of JIP3 alone shows an unexpected antiparallel arrangement.
Results demonstrated the increased expression of JIP3 in the temporal neocortex of TLE patients and in the experimental model of epileptic seizures
JSAP1 and JLP (Montrer SPAG9 Anticorps) play critical roles in kinesin-1-dependent axonal transport
The results of this study finding suggested that a model by which the self-assembly of SYD-2/Liprin (Montrer PPFIA1 Anticorps)-alpha proteins mediated by the coiled-coil LH1 domain is one of the key steps to the accumulation of presynaptic components at nascent synaptic junctions
This study demonistrated that JIP3 mediates TrkB (Montrer NTRK2 Anticorps) axonal anterograde transport and enhances BDNF (Montrer BDNF Anticorps) signaling by directly bridging TrkB (Montrer NTRK2 Anticorps) with kinesin-1.
Expression of constitutively active PI3K (Montrer PIK3CA Anticorps) stimulated translocation of Tiam1 (Montrer TIAM1 Anticorps) to the membrane, increased Rac1 activity, and increased wound healing of airway epithelial cells. Increased Rac1 activity resulted in increased phosphorylation of JNK1 (Montrer MAPK8 Anticorps).
demonstration that JSAP1 bound ASK1 (Montrer MAP3K5 Anticorps) and enhanced ASK1 (Montrer MAP3K5 Anticorps)- and H2O2-induced JNK (Montrer MAPK8 Anticorps) activity
Pressure application of 160 mmHg for 3 h produced cell proliferation and activated ERK (Montrer EPHB2 Anticorps) and c-JUN N-terminal kinase
JIP1 (Montrer MAPK8IP1 Anticorps) and JIP3, have a cross-talk that leads to the regulation of the ASK1 (Montrer MAP3K5 Anticorps)-SEK1 (Montrer MAP2K4 Anticorps)-JNK (Montrer MAPK8 Anticorps) signal during glucose deprivation; cross-talk between JIP3 and JIP1 (Montrer MAPK8IP1 Anticorps) is mediated through SEK1 (Montrer MAP2K4 Anticorps)-JNK2 (Montrer MAPK9 Anticorps) and Akt1 (Montrer AKT1 Anticorps).
JSAP1.FAK (Montrer PTK2 Anticorps) complex functions cooperatively as a scaffold for the JNK (Montrer MAPK8 Anticorps) signaling pathway and regulator of cell migration on FN
JIP3 absence is associated with decreased lipogenesis, oxidative stress and inflammation, supplying a new target for nonalcoholic fatty liver disease treatment.
These results establish the critical role of JIP3-dependent axonal lysosome transport in regulating amyloidogenic amyloid precursor protein (Montrer APP Anticorps) processing and support a model wherein Abeta (Montrer APP Anticorps) production is amplified by plaque-induced axonal lysosome transport defects.
Data show that c-Jun NH2-terminal kinase (JNK (Montrer MAPK8 Anticorps))-interacting protein-3 (JIP3) participates in the migration of cortical neurons during cortical development by mediating TrkB (Montrer NTRK2 Anticorps) receptor axonal anterograde transport.
JSAP1/JIP3 and JLP (Montrer SPAG9 Anticorps) regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration
These findings reveal that JIP3 regulation of kinesin-1 motility is critical for axon elongation and regeneration.
JSAP1 and JLP (Montrer SPAG9 Anticorps), which might be paralogous to each other, are critical and functionally redundant in cytokinesis and control ARF6 (Montrer ARF6 Anticorps) localization to the midbody by forming a tripartite complex of JSAP1/JLP (Montrer SPAG9 Anticorps), active ARF6 (Montrer ARF6 Anticorps), and kinesin-1.
JIP3 regulates neuronal axon elongation in a kinesin- and JNK (Montrer MAPK8 Anticorps)-dependent manner
Results suggest that JSAP1 is required for the pathfinding of the developing telencephalic commissures in the early brains.
syd activates kinesin heavy chain for transport & enhances its motility, increasing its velocity & run length. syd mutants binding KHC but not kinesin light chain are transported to axons & dendrites normally.
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
mitogen-activated protein kinase 8 interacting protein 3
, C-Jun-amino-terminal kinase-interacting protein 3
, JNK-interacting protein 3
, c-Jun-amino-terminal kinase-interacting protein 3-like
, C-jun-amino-terminal kinase interacting protein 3
, JNK MAP kinase scaffold protein 3
, JNK/SAPK-associated protein-1
, JNK/stress-activated protein kinase-associated protein 1
, homolog of Drosophila Sunday driver 2
, mitogen-activated protein kinase 8-interacting protein 3
, JNK/SAPK-associated protein 1
, JNK/SAPK-associated protein 1c
, JUN/SAPK-associated protein 1
, c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1
, mitogen activated protein kinase 8 interacting protein 3
, sunday driver 2