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Involved in JNK signaling pathway (By similarity)..
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Human Polyclonal MAPKBP1 Primary Antibody pour ICC, IF - ABIN4332694
Lecat, Di Valentin, Somja, Jourdan, Fillet, Kufer, Habraken, Sadzot, Louis, Delvenne, Piette, Legrand-Poels: The c-Jun N-terminal kinase (JNK)-binding protein (JNKBP1) acts as a negative regulator of NOD2 protein signaling by inhibiting its oligomerization process. dans The Journal of biological chemistry 2012
We identified mutations in MAPKBP1 as a genetic cause of juvenile or late-onset and cilia-independent nephronophthisis.
JNKBP1 and NOD2 (Montrer NOD2 Anticorps) are co-expressed in the human intestinal epithelium and in immune cells recruited in the lamina propria, which suggests that JNKBP1 contributes to maintain NOD2 (Montrer NOD2 Anticorps)-mediated intestinal immune homeostasis.
The Mapkbp1 protein could enhance the NF-kappaB (Montrer NFKB1 Anticorps) activation induced by MAP kinase (Montrer MAPK1 Anticorps) kinase kinase 7 and TNF Receptor-Associated Factor 2 (Montrer TRAF2 Anticorps) , and could promote TNF Receptor-Associated Factor 2 (Montrer TRAF2 Anticorps) polyubiquitination.
Involved in JNK signaling pathway (By similarity).
mitogen-activated protein kinase-binding protein 1
, mitogen-activated protein kinase binding protein 1
, JNK-binding protein 1
, mitogen activated protein kinase binding protein 1
, Jun N-terminal kinase binding protein 1
, Jun N-terminal kinase-binding protein 1