anti-Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK) Anticorps

ZAK is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). De plus, nous expédions ZAK Protéines (8) et ZAK Kits (4) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
ZAK 311743  
ZAK 51776 Q9NYL2
ZAK 65964 Q9ESL4
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Top anti-ZAK Anticorps sur anticorps-enligne.fr

Showing 10 out of 115 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué IC, IF, WB Immunofluorescent analysis of ZAK staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Western blot analysis of ZAK expression in HeLa (A), HepG2 (B), NIH3T3 (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of extracts from Jurkat cells, using ZAK (Ab-165) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Détails
Humain Lapin Inconjugué IF, ELISA, WB Western blot analysis of extracts from HeLa cells, using MLTK Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HepG2 cells, using MLTK Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Détails
Humain Lapin Inconjugué WB WB Image Sample (30 ug of whole cell lysate) A: A549 7.5% SDS PAGE antibody diluted at 1:1000 100 μL 3 to 4 Days
$466.18
Détails
Humain Lapin Inconjugué ELISA, IF, WB 100 μL Disponible
$363.46
Détails
Humain Souris Inconjugué IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to ZAK on formalin-fixed paraffin-embedded human prostate. [antibody concentration 3 ug/ml] ZAK monoclonal antibody (M03), clone 3G5. Western Blot analysis of ZAK expression in human stomach. 100 μg 11 to 12 Days
$440.00
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of ZAK (Phospho-Ser165) using HeLa whole cell lysates 100 μL 11 to 12 Days
$450.00
Détails
Humain Lapin Inconjugué ELISA, ICC, IF, WB Western blot analysis of extracts from HeLa cells, using MLTK antibody.The lane on the left is treated with the antigen-specific peptide. ABIN6274530 staining HepG2 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. 100 μL 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB 0.4 mL 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis in HepG2 cell line lysate (35ug/lane). MLKLAK-C284(arrow) was detected using the purified Pab. This Western blot detected isoform 2 of MLKLAK, the accession number for MLKLAK isoform 1 is Q9NYL2, NP_057737. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma; HC = hepatocarcinoma. 400 μL 2 to 3 Days
$515.63
Détails

anti-ZAK Anticorps mieux référencés

  1. Human Monoclonal ZAK Primary Antibody pour IF, IHC (p) - ABIN565679 : Cariolato, Cavin, Diviani: A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in ?1-adrenergic receptor-induced p38 activation. dans The Journal of biological chemistry 2011 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal ZAK Primary Antibody pour IHC (p), ELISA - ABIN544235 : Jhiang: The RET proto-oncogene in human cancers. dans Oncogene 2000 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal ZAK Primary Antibody pour ICC, IF - ABIN4366552 : Liu, McCleland, Stawiski, Gnad, Mayba, Haverty, Durinck, Chen, Klijn, Jhunjhunwala, Lawrence, Liu, Wan, Chopra, Yaylaoglu, Yuan, Ha, Gilbert, Reeder, Pau, Stinson, Stern, Manning, Wu, Neve et al.: Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer. ... dans Nature communications 2014 (PubMed)

Plus d’anticorps contre ZAK partenaires d’interaction

Human Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK) interaction partners

  1. promoting epithelial mesenchymal transition is the primary role for ZAK in cancer progression.

  2. MLK7AS1 has potential as a biomarker and may promote proliferation in CRC partially through downregulating p21 expression.

  3. The ZAK rs3769201 and rs722864 may be functional susceptibility loci for lung cancer risk.

  4. The expression of ZAKbeta is dependent on ZAKalpha expression, and ZAKbeta further enhances ZAKalpha expression and results in synergistic enhancement of apoptosis in osteosarcoma cells.

  5. Gene set enrichment analysis disclosed a significant correlation between ZAK+ colorectal premalignant lesions and gene sets belonging to the MAPK/ERK and motility-related signaling pathways of the reactome database, strongly suggesting that ZAK induces such pro-tumoral reaction cascades in human cancers.

  6. Recessive mutations in the kinase ZAK - novel cause of congenital myopathy.

  7. ZAK is a key player in mammalian limb patterning in humans and mice.

  8. ZAK kinase isoform TV1 is preferentially upregulated in gastric tumours and cell lines relative to normal samples. This pattern is also observed in colorectal, bladder and breast cancers.

  9. The long non-coding RNA URHC promotes cell proliferation and inhibits apoptosis by repressing ZAK expression through inactivation of the ERK/MAPK pathway.

  10. we report that sorafenib suppresses UV-induced apoptosis specifically by inhibiting c-jun-NH(2)-kinase (JNK) activation through the off-target inhibition of leucine zipper and sterile alpha motif-containing kinase (ZAK)

  11. MRK is a novel RhoC effector that controls LPA-stimulated cell invasion at least in part by regulating myosin dynamics, ERK and p38

  12. The genes identified KTN1, ROCK1, and ZAK may be responsible for loss of cellular homeostasis in giant cells tumors of bone

  13. decrease of lung cancer cell proliferation by ZAK may involve the ERK and JNK pathways via an AP-1 transcription factor.

  14. In this study, by applying a novel method, we have identified the phosphorylation sites in human MSK1 mitogen- and stress-activated protein kinase 1, and show that MRK-beta could also activate MSK1 through direct interaction.

  15. Results suggest that ZAK might play a role as an upstream signal to suppress the ZZaPK function and decrease E2F expression.

  16. Data show that in response to radiation, MRK controls two independent pathways: the Chk2-Cdc25A pathway leading to cell cycle arrest and the p38gamma MAPK pathway

  17. Results suggest that a ZAK mediates TGF-beta-induced cardiac hypertrophic growth via a novel TGF-beta signaling pathway.

  18. ZAK induces characteristic hypertrophic growth features, including increased cell size, elevated atrial natriuretic factor expression, and increased actin fiber organization

  19. Mixed lineage kinase 7 (MLK7), a splice variant of the ZAK gene, encodes an isoform which is the MAPKKK required for modulation of the stress-activated MAPKs downstream of anisomycin and UV stimulation.

  20. data demonstrate that a ZAK isoform(s) is the MAP3Kinase that transduces the ribotoxic stress response

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK) interaction partners

  1. Zak-/- mice demonstrate a distinct ribotoxic stress-associated phenotype in response to ricin.

  2. ZAK is a key player in mammalian limb patterning in humans and mice.

  3. Exome sequencing analysis between SM/J and A/J mice identified 4 genes (Itga6, Zak, Gpr155, and Mtx2) with nonsynonymous coding SNPs. These four genes might be candidate genes for type 2 diabetes caused by gene-gene interactions.

  4. PKNalpha functions as not only an upstream activator of MLTKalpha but also a putative scaffold protein for the p38gamma MAPK signaling pathway

  5. Results show that mixed lineage kinase-like mitogen-activated protein triple kinase (MLTK_-alpha plays a key role in the UVB- and EGF-induced phosphorylation of histone H3 at Ser28.

  6. Mixed lineage kinase 7 (MLK7), a splice variant of the human ZAK gene (ortholog of mouse B230120H23Rik), encodes an isoform which is the MAPKKK required for modulation of the stress-activated MAPKs downstream of anisomycin and UV stimulation.

ZAK profil antigène

Profil protéine

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with ZAK

  • mitogen-activated protein kinase kinase kinase 20 (Map3k20) anticorps
  • mitogen-activated protein kinase kinase kinase 20 (MAP3K20) anticorps
  • AV006891 anticorps
  • AZK anticorps
  • B230120H23Rik anticorps
  • MLK7 anticorps
  • mlklak anticorps
  • MLT anticorps
  • MLTK anticorps
  • MLTKalpha anticorps
  • MLTKbeta anticorps
  • MRK anticorps
  • pk anticorps
  • RGD1561394 anticorps

Protein level used designations for ZAK

mitogen-activated protein kinase kinase kinase MLT , HCCS-4 , MLK-like mitogen-activated protein triple kinase , human cervical cancer suppressor gene 4 protein , mixed lineage kinase 7 , mixed lineage kinase with a leucine zipper and a sterile alpha motif , mixed lineage kinase-related kinase MRK-beta , MLK-related kinase , MRK , leucine zipper- and sterile alpha motif kinase ZAK , mixed lineage kinase-related kinase , sterile alpha motif- and leucine zipper-containing kinase AZK , sterile-alpha motif and leucine zipper containing kinase AZK

GENE ID SPECIES
311743 Rattus norvegicus
51776 Homo sapiens
65964 Mus musculus
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