Mov10l1, Moloney Leukemia Virus 10-Like 1, Homolog (Mouse) Protéines (MOV10L1)

MOV10L1 is similar to a mouse gene that encodes a putative RNA helicase and shows testis-specific expression. De plus, nous expédions MOV10L1 Anticorps (19) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MOV10L1 83456 Q99MV5
MOV10L1 54456 Q9BXT6
Rat MOV10L1 MOV10L1 300141  
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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MOV10L1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human ,
,

Plus protéines pour Mov10l1, Moloney Leukemia Virus 10-Like 1, Homolog (Mouse) (MOV10L1) partenaires d'interaction

Mouse (Murine) Mov10l1, Moloney Leukemia Virus 10-Like 1, Homolog (Mouse) (MOV10L1) interaction partners

  1. MOV10L1 is essential for the primary processing of pachytene piRNAs. MOV10L1 acts upstream of PIWI proteins in the piRNA pathway and is a master regulator of the piRNA biogenesis.

  2. Mutations in the conserved ATP hydrolysis motif of MOV10L1 block piRNA biogenesis and result in male sterility.

  3. MOV10L1 exhibits 5'-to-3' directional RNA-unwinding activity in vitro and its RNA helicase activity is required for primary piRNA biogenesis in vivo. MOV10L1 selectively binds piRNA precursor transcripts. MOV10L1 is essential for the generation of intermediate piRNA processing fragments. piRNA precursor processing is intimately coupled with elements of local secondary structures such as G quadruplexes.

  4. Mov10l1 mutant males are sterile owing to complete meiotic arrest. This mutant expresses Piwi proteins but lacks piRNAs, suggesting that MOV10L1 is required for piRNA biogenesis and/or loading to Piwi proteins.

  5. studies reveal a crucial role of MOV10L1 in male fertility and piRNA-directed retrotransposon silencing in male germ cells and suggest that MOV10L1 functions as a key component of a safeguard mechanism for the genetic information in male germ cells

  6. expression in oocytes sensitive to TAF4B level

  7. CHAMP acts as an inhibitor of cell proliferation and cardiomyocyte hypertrophy.

  8. Nkx2.5 (Montrer NKX2-5 Protéines) transactivates the Csm promoter, suggesting that Nkx2.5 (Montrer NKX2-5 Protéines) is essential for embryonic Csm (cardiac-specific isoform of Mov10l1) expression

Human Mov10l1, Moloney Leukemia Virus 10-Like 1, Homolog (Mouse) (MOV10L1) interaction partners

  1. Our results suggest that MOV10L1 gene polymorphisms in the studied infertile males with complete maturation arrest are linked to infertility.

Profil protéine MOV10L1

Profil protéine

This gene is similar to a mouse gene that encodes a putative RNA helicase and shows testis-specific expression. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MOV10L1

  • Mov10 RISC complex RNA helicase like 1 (MOV10L1)
  • Mov10 RISC complex RNA helicase like 1 (mov10l1)
  • Moloney leukemia virus 10-like 1 (Mov10l1)
  • Mov10 RISC complex RNA helicase like 1 (Mov10l1)
  • CHAMP Protéine
  • Csm Protéine
  • DJ402G11.8 Protéine

Protein level used designations for MOV10L1

Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) , Mov10l1-like protein , MOV10-like 1 , putative helicase Mov10l1-like , MOV10-like protein 1 , cardiac helicase activated by MEF2 protein , cardiac-specific RNA helicase , moloney leukemia virus 10-like protein 1 , putative helicase Mov10l1 , Mov10-like 1 , cardiac helicase activated by MEF2C protein , Moloney leukemia virus 10-like 1 , Mov10l1, Moloney leukemia virus 10-like 1, homolog

GENE ID SPECIES
100056030 Equus caballus
100083059 Ornithorhynchus anatinus
100139822 Bos taurus
100351875 Oryctolagus cuniculus
100519488 Sus scrofa
100539488 Meleagris gallopavo
100565506 Anolis carolinensis
83456 Mus musculus
54456 Homo sapiens
474460 Canis lupus familiaris
300141 Rattus norvegicus
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