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MOV10L1 is similar to a mouse gene that encodes a putative RNA helicase and shows testis-specific expression. De plus, nous expédions MOV10L1 Anticorps (20) et beaucoup plus de produits pour cette protéine.
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MOV10L1 is essential for the primary processing of pachytene piRNAs. MOV10L1 acts upstream of PIWI proteins in the piRNA pathway and is a master regulator of the piRNA biogenesis.
Mutations in the conserved ATP hydrolysis motif of MOV10L1 block piRNA biogenesis and result in male sterility.
MOV10L1 exhibits 5'-to-3' directional RNA-unwinding activity in vitro and its RNA helicase activity is required for primary piRNA biogenesis in vivo. MOV10L1 selectively binds piRNA precursor transcripts. MOV10L1 is essential for the generation of intermediate piRNA processing fragments. piRNA precursor processing is intimately coupled with elements of local secondary structures such as G quadruplexes.
Mov10l1 mutant males are sterile owing to complete meiotic arrest. This mutant expresses Piwi proteins but lacks piRNAs, suggesting that MOV10L1 is required for piRNA biogenesis and/or loading to Piwi proteins.
studies reveal a crucial role of MOV10L1 in male fertility and piRNA-directed retrotransposon silencing in male germ cells and suggest that MOV10L1 functions as a key component of a safeguard mechanism for the genetic information in male germ cells
expression in oocytes sensitive to TAF4B level
CHAMP acts as an inhibitor of cell proliferation and cardiomyocyte hypertrophy.
Nkx2.5 transactivates the Csm promoter, suggesting that Nkx2.5 is essential for embryonic Csm (cardiac-specific isoform of Mov10l1) expression
Our results suggest that MOV10L1 gene polymorphisms in the studied infertile males with complete maturation arrest are linked to infertility.
This gene is similar to a mouse gene that encodes a putative RNA helicase and shows testis-specific expression. Multiple transcript variants encoding different isoforms have been found for this gene.
Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)
, Mov10l1-like protein
, MOV10-like 1
, putative helicase Mov10l1-like
, MOV10-like protein 1
, cardiac helicase activated by MEF2 protein
, cardiac-specific RNA helicase
, moloney leukemia virus 10-like protein 1
, putative helicase Mov10l1
, Mov10-like 1
, cardiac helicase activated by MEF2C protein
, Moloney leukemia virus 10-like 1
, Mov10l1, Moloney leukemia virus 10-like 1, homolog