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MRVI1 is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). De plus, nous expédions Murine Retrovirus Integration Site 1 Homolog Anticorps (6) et Murine Retrovirus Integration Site 1 Homolog Kits (5) et beaucoup plus de produits pour cette protéine.
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cGKIbeta signaling via IRAG is essential for regulation of smooth muscle tone and of intracellular calcium by NO and by atrial natriuretic peptide.
conclude that cGMP-dependent relaxation of hormone receptor-triggered smooth muscle contraction essentially depends on the interaction of cGKI-IRAG with IP(3)RI
Reports use of non-AUG (CUG) translation initiation codon in one of the transcript variants of MRVI1 gene in mouse and human.
p.P186S substitution (rs35857561) in MRVI1 that segregated with moyamoya syndrome in both the Italian and German family. rs35857561 polymorphism in MRVI1 may be a genetic susceptibility factor for moyamoya in European patients with neurofibromatosis type 1. MRVI1 is a functional partner of ITPR1, PRKG1 and GUCY1A3, which are involved in response to nitric oxide.
In the present study we analyzed the structure and function of the human IRAG/MRVI1 gene
IRAG is required for PKG1beta-regulated cyclic calcium release during motility of osteoclasts
IRAG appears to be essentially involved in the NO/cGK-dependent inhibition of InsP(3)-dependent Ca(2+)-signaling in colonic smooth muscle
cGMP-dependent protein kinase Ibeta binds to TFII-I and IRAG through a common interaction motif
These findings reveal that interaction between IRAG and InsP3RI has a central role in NO/cGMP-dependent inhibition of platelet aggregation and in vivo thrombosis.
This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.
JAW1-related protein MRVI1
, inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate
, inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate
, murine retrovirus integration site 1 protein
, protein MRVI1
, retroviral integration site 1
, IP3R-associated cGMP kinase substrate
, IP3 receptor associated cGMP kinase substrate