Muscleblind-Like 2 (Drosophila) Protéines (MBNL2)

MBNL2 is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. De plus, nous expédions MBNL2 Anticorps (31) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MBNL2 105559 Q8C181
MBNL2 10150 Q5VZF2
MBNL2 680445 F2Z3T4
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
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Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
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HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
$888.80
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Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,023.17
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MBNL2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human , ,
, ,
Rat (Rattus)

Plus protéines pour Muscleblind-Like 2 (Drosophila) (MBNL2) partenaires d'interaction

Mouse (Murine) Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. This study uncovers non-canonical functions of MBNL proteins (Mbnl1/2) that bind and promote the expression of miR-294 targets, including Cdkn1a and Tgfbr2, thereby opposing the role of miR-294 in regulating cell proliferation, apoptosis, and epithelial-mesenchymal transition (EMT).

  2. Mbnl1(+/-); Mbnl2(+/-) knockout mice with myotonic dystrophy presented with clinical myofibril ultrastructural abnormality and cardiac arrhythmias.

  3. Depletion of Mbnl1 and/or Mbnl2 reduced localization of hundreds of transcripts, implicating Mbnls in localization of mRNAs to neurites

  4. Sense DMPK RNA foci clearly co-localize with MBNL1 and MBNL2 proteins and accumulate in myotonic dystrophy 1 tissues during development.

  5. depletion of Mbnl proteins in mouse embryo fibroblasts leads to misregulation of thousands of alternative polyadenylation events.

  6. consistent with a central and negative regulatory role for MBNL proteins in pluripotency, their knockdown significantly enhances the expression of key pluripotency genes and the formation of induced pluripotent stem cells during somatic cell reprogramming

  7. This analysis identified several hundred splicing events whose regulation depended on Mbnl function in a pattern indicating functional interchangeability between Mbnl1 and Mbnl2.

  8. We propose that major pathological features of the myotonic dystrophy brain result from disruption of the MBNL2-mediated developmental splicing program

  9. Conserved developmental stage- and tissue-specific alternative splicing of MBNL transcripts is an important mechanism by which MBNL activity is regulated during embryonic development.

  10. The authors propose that expanded CTG DNA repeats cause two separate effects: loss of Mbnl1 function (disrupting splicing) and loss of another function that disrupts extracellular matrix mRNA regulation, possibly mediated by Mbnl2.

  11. MBNL2 contribute to the pathogenesis of myotonic dystrophy.

Zebrafish Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. MBNL2 in splicing regulation of specific transcripts, which, when altered, contributes to the myotonic dystrophy phenotype.

Human Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. Functional depletion of the alternative splicing factors Muscleblind-like (MBNL 1 and 2) is at the basis of the neuromuscular disease myotonic dystrophy type 1 (DM1). Here, we screen for miRNAs that regulate MBNL1 and MBNL2 in HeLa cells. We thus identify miR-23b and miR-218, and confirm that they downregulate MBNL proteins in this cell line.

  2. Low MBNL2 expression is associated with hepatocellular carcinoma growth and invasion.

  3. Sense DMPK RNA foci clearly co-localize with MBNL1 and MBNL2 proteins and accumulate in myotonic dystrophy 1 tissues during development.

  4. both MBNL1 and MBNL2 are involved in the regulation of Tau exon 2 splicing and the mis-splicing of Tau in DM1 is due to the combined inactivation of both

  5. consistent with a central and negative regulatory role for MBNL proteins in pluripotency, their knockdown significantly enhances the expression of key pluripotency genes and the formation of induced pluripotent stem cells during somatic cell reprogramming

  6. We propose that major pathological features of the myotonic dystrophy brain result from disruption of the MBNL2-mediated developmental splicing program

  7. MBNL proteins promote opposite splicing patterns for cardiac troponin T and insulin receptor alternative exons

  8. MBNL1 and MBNL2 always co-distributed. Functional differences between MBNL1 and MBNL2 have not yet been found

  9. solution structures of both tandem zinc finger (TZF) motifs, TZF12 (comprising ZF1 and ZF2) and TZF34 (ZF3 and ZF4), in MBNL2

Profil protéine MBNL2

Profil protéine

This gene is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. This gene encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined.

Gene names and symbols associated with MBNL2

  • muscleblind like splicing factor 2 (Mbnl2)
  • muscleblind-like splicing regulator 2 (mbnl2)
  • muscleblind like splicing regulator 2 (MBNL2)
  • muscleblind-like splicing regulator 2 (Mbnl2)
  • 1110002M11Rik Protéine
  • AI047808 Protéine
  • AI837313 Protéine
  • AI849185 Protéine
  • AL118326 Protéine
  • MBLL Protéine
  • MBLL39 Protéine
  • mKIAA4072 Protéine
  • PRO2032 Protéine
  • R75232 Protéine
  • wu:fj89c04 Protéine

Protein level used designations for MBNL2

muscleblind-like protein 2 , fj89c04 , muscleblind-like 2 , muscleblind-like protein 1 , muscleblind-like protein-like 39

GENE ID SPECIES
105559 Mus musculus
560384 Danio rerio
418784 Gallus gallus
527679 Bos taurus
10150 Homo sapiens
612815 Canis lupus familiaris
680445 Rattus norvegicus
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