anti-Mycn (MYCN) Anticorps

MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. De plus, nous expédions MYCN Kits (8) et MYCN Protéines (7) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
MYCN 4613 P04198
MYCN 18109 P03966
MYCN 298894 Q63379
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Top anti-MYCN Anticorps sur anticorps-enligne.fr

Showing 10 out of 92 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB 100 μL 3 to 7 Days
$339.90
Détails
Humain Lapin Inconjugué WB 100 μg 4 to 6 Days
$240.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-MYCN Antibody Titration:  2.5ug/ml  Positive Control:  Human heart 100 μL 2 to 3 Days
$229.00
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of MYCN antibody (C-term) in CEM cell line lysates (35ug/lane). MYCN (arrow) was detected using the purified Pab. 0.4 mL 6 to 8 Days
$522.50
Détails
Roussette (Chauve-souris) Lapin Inconjugué WB 100 μL 11 to 14 Days
$493.17
Détails
Humain Lapin Inconjugué ELISA, IHC, WB ABIN6268752 at 1/100 staining human brain tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of N Myc expression in CACO-2 cells 100 μL 11 to 12 Days
$390.77
Détails
Humain Souris Inconjugué ELISA, WB 100 μg 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué WB Western blot analysis of extracts of various cell lines, using MYCN antibody (ABIN1873796) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s. 100 μL 11 to 13 Days
$363.06
Détails
Humain Lapin Inconjugué ELISA, WB 100 μL 11 to 14 Days
$419.83
Détails
Humain Souris Inconjugué RNAi, ELISA, WB MYCN monoclonal antibody (M01), clone 3H4 Western Blot analysis of MYCN expression in HepG2 . Western blot analysis of MYCN over-expressed 293 cell line, cotransfected with MYCN Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with MYCN monoclonal antibody (M01), clone 3H4. GAPDH ( 36.1 kDa ) used as specificity and loading control. 100 μg 11 to 12 Days
$364.00
Détails

anti-MYCN Anticorps mieux référencés

  1. Human Monoclonal MYCN Primary Antibody pour ChIP, CyTOF - ABIN152254 : Tasseva, Cole, Vance: N-Myc and SP regulate phosphatidylserine synthase-1 expression in brain and glial cells. dans The Journal of biological chemistry 2011 (PubMed)
    Show all 3 Pubmed References

  2. Mouse (Murine) Polyclonal MYCN Primary Antibody pour ICC, IF - ABIN256650 : Sjostrom, Finn, Hahn, Rowitch, Kenney: The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. dans Developmental cell 2005 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal MYCN Primary Antibody pour IF (p), IHC (p) - ABIN760676 : Ramraj, Aravindan, Somasundaram, Herman, Natarajan, Aravindan: Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease. dans Oncotarget 2016 (PubMed)

  4. Human Polyclonal MYCN Primary Antibody pour WB - ABIN6669579 : Chang, Yang, Zheng, Li, Nie: Arsenic trioxide inhibits cancer stem-like cells via down-regulation of Gli1 in lung cancer. dans American journal of translational research 2016 (PubMed)

Plus d’anticorps contre MYCN partenaires d’interaction

Human Mycn (MYCN) interaction partners

  1. MYCN induces E2F5 expression in neuroblastoma cells. E2F5 is a direct target of MYCN in neuroblastoma cells.

  2. MYCN expression in the adult B-cell acute lymphoblastic leukaemia. MYCN directly binds to the DKK3 promoter but has no effect on DKK3 promoter methylation.

  3. Because BRCA1 is highly expressed in neuronal progenitor cells during early development and MYC is less efficient than MYCN in recruiting BRCA1, our findings indicate that a cell-lineage-specific stress response enables MYCN-driven tumours to cope with deregulated RNAPII function

  4. MiR-144 inhibits proliferation, promotes apoptosis and enhances the sensitivity of neuroblastoma cells to DDP through targeting MYCN, which provides a potential treatment for neuroblastoma.

  5. MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to a reactive oxygen species-augmenting agent.

  6. These results indicate that while individuals with deletions of 2p spanning several megabases and including MYCN can present with features not typically associated with FS1, the common core features are usually present.

  7. Results show that MYCN is upregulated in pediatric hepatoblastoma (HB) tumors due to the transcriptional activity of its antisense transcript, MYCNOS. Hypomethylation of the MYCN/MYCNOS locus is associated with high expression levels.

  8. Study identified miR-204 as a tumor suppressor miRNA that inhibited a subnetwork of oncogenes strongly associated with MYCN-amplified neuroblastoma and poor patient outcome. MYCN bound to the miR-204 promoter and repressed miR-204 transcription. Conversely, miR-204 directly bound MYCN mRNA and repressed MYCN expression.

  9. The combination treatment with GA and vorinostat synergistically reduced cell survival in the MYCN and CD71 overexpressing tumor cells. The same treatment had no effect or minimal effect on HEK293 and HEF cells used as models of non-cancer cells.

  10. crocin significantly inhibited the cell proliferation and clonogenicity and induced cell apoptosis in Y79 and WERI-RB-1 cells. In addition, crocin treatment significantly reduced the expression and the stability of MYCN. Besides, overexpression of MYCN rescued the inhibitory effect of crocin in Y79 cells.

  11. N-Myc differentially regulating miR-421/ATM pathway contributes to ADT resistance and Enzalutamide resistance development respectively.

  12. Present the first dynamic chromatin and transcriptional landscape of MYCN perturbation in neuroblastoma. At oncogenic levels, MYCN associates with E-box binding motifs in an affinity-dependent manner, binding to strong canonical E-boxes at promoters and invading abundant weaker non-canonical E-boxes clustered at enhancers.

  13. these observations demonstrate that MYCN upregulates EZH2, leading to inactivation of a tumor suppressor program in neuroblastoma, and support testing EZH2 inhibitors in patients with MYCN-amplified neuroblastoma.

  14. There was no difference in survival rates according to MYCN amplification in patients with high-risk neuroblastoma

  15. CX-5461 repressed the growth of established MYCN-amplified neuroblastoma xenograft tumors in nude mice.

  16. HBP1 inhibits both the transcriptional activating and repressing activity of MYCN.

  17. A set of critical dependency genes in MYCN-amplified neuroblastoma.

  18. A common pathway connecting n-MYC, NAMPT and SIRT1 may be active in basal cell carcinomas and in their cells of origin, contributing to their development.

  19. TFAP4 is a key regulator of MYCN-amplified neuroblastom

  20. restoration of MYCN reversed the effects of miR5013p in cisplatinresistant glioma cells. In conclusion, these results suggested that miR5013p may serve a promising marker for cisplatin resistance.

Mouse (Murine) Mycn (MYCN) interaction partners

  1. Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis.

  2. cardiomyocytes compete according to their combined Myc and Mycn levels and that cell competition eliminates flawed cardiomyocytes, suggesting its relevance as a quality control mechanism in cardiac development.

  3. MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to a reactive oxygen species-augmenting agent.

  4. Studied effect of CX-5461 on downregulation of MYCN in neuroblastoma cell lines and mouse models.

  5. IL-32epsilon induces caspase-independent apoptosis mediated by N-Myc interactor in macrophages infected with Mycobacterium tuberculosis.

  6. A common pathway connecting n-MYC, NAMPT and SIRT1 may be active in basal cell carcinomas and in their cells of origin, contributing to their development.

  7. Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models.

  8. MYCN-promoted SGO1 transcription and SGO1 expression tended to be higher in MYCN- or MYC-overexpressing cancers. Together, these findings indicate that SGO1 plays a role in the DNA damage response in interphase.

  9. interactions of NF-kappaB and N-myc with GLT-1/EAAT2 promoter sequences was significantly elevated in the ipsi-lateral cortex of both adult and old Traumatic brain injury mice.

  10. beta-catenin cooperates with the transcription factor Myc to activate the progenitor renewal program.

  11. we report the isolation and propagation of neuroblastoma sphere-forming cells with self-renewal and differentiation potential from tumors of the TH-MYCN mouse, an animal model of high-risk neuroblastoma with MYCN amplification

  12. miR-34a contributes to the expansion of Myeloid-derived suppressor cells by inhibiting the apoptosis via suppressing the expression of N-myc.

  13. the role of N-myc in mouse lens development, was examined.

  14. Using comparative genomic hybridization, authors found that NCC-derived NBL tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL including 17q gain, 2p gain and loss of 1p36.

  15. a Mycn target gene encoding the miR cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.

  16. The findings reveal a PLK1-Fbw7-Myc signaling circuit that underlies tumorigenesis and validate PLK1 inhibitors, alone or with Bcl2 antagonists, as potential effective therapeutics for MYC-overexpressing cancers.

  17. ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.

  18. Reuslts show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.

  19. Thus, this synergistic effect of ZD55-shMYCN in combination with doxorubicin provides a novel therapy strategy for doxorubicin-resistant neuroblastoma, and is a promising approach for further clinical development.

  20. demonstrate a critical link between Myc/Mycn gene activity and glycolysis in spermatogonial stem cell self-renewal

Zebrafish Mycn (MYCN) interaction partners

  1. In MYCN transgenic fish, Gab2 overexpression activated the Shp2-Ras-Erk pathway, enhanced neuroblastoma induction, and increased tumor penetrance.

  2. The authors demonstrate in zebrafish that nf1 loss leads to aberrant activation of RAS signaling in MYCN-induced neuroblastomas that arise in these precursors, and that the GTPase-activating protein (GAP)-related domain (GRD) is sufficient to suppress the acceleration of neuroblastoma in nf1-deficient fish, but not the hypertrophy of sympathoadrenal cells in nf1 mutant embryos.

  3. At somitogenesis stages, nmyc1 expression was detected in the retina, midbrain, posterior hindbrain and presumptive spinal cord. It was also transcribed in the endoderm and its derivatives as well as in branchial arches.

MYCN profil antigène

Profil protéine

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.

Gene names and symbols associated with anti-Mycn (MYCN) Anticorps

  • MYCN proto-oncogene, bHLH transcription factor (MYCN) anticorps
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) anticorps
  • v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (Mycn) anticorps
  • MYCN proto-oncogene, bHLH transcription factor (Mycn) anticorps
  • olfactory receptor 8S1 (LOC515887) anticorps
  • MYCN proto-oncogene, bHLH transcription factor (mycn) anticorps
  • MYCN proto-oncogene, bHLH transcription factor S homeolog (mycn.S) anticorps
  • bHLHe37 anticorps
  • c-nmyc anticorps
  • fb57a02 anticorps
  • MODED anticorps
  • mycn anticorps
  • mycn-a anticorps
  • mycn-b anticorps
  • mycna anticorps
  • MYCNOT anticorps
  • N-myc anticorps
  • Nmuc1 anticorps
  • Nmyc anticorps
  • Nmyc-1 anticorps
  • nmyc1 anticorps
  • ODED anticorps
  • wu:fb57a02 anticorps
  • XN-myc anticorps
  • xN-myc1 anticorps
  • XNmyc anticorps
  • zgc:85706 anticorps

Protein level used designations for anti-Mycn (MYCN) Anticorps

N-myc proto-oncogene protein , class E basic helix-loop-helix protein 37 , neuroblastoma MYC oncogene , neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene , oncogene NMYC , pp65/67 , v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived , N-myc protein , neuroblastoma myc-related oncogene 1 , Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc) , Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc) , N-myc-like protein , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog , MYCN proto-oncogene, bHLH transcription factor S homeolog , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog S homeolog , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived, a

GENE ID SPECIES
4613 Homo sapiens
482978 Canis lupus familiaris
421948 Gallus gallus
18109 Mus musculus
298894 Rattus norvegicus
515887 Bos taurus
252851 Danio rerio
380041 Xenopus laevis
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