Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 1 Protéines (MLLT1)

Capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells.. De plus, nous expédions MLLT1 Anticorps (38) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
Rat MLLT1 MLLT1 301119  
MLLT1 4298 Q03111
Souris MLLT1 MLLT1 64144  
Comment commander chez anticorps-enligne
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Commandez enligne
  • orders@anticorps-enligne.fr

Top MLLT1 Protéines sur anticorps-enligne.fr

Showing 3 out of 3 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Détails
Wheat germ Humain GST tag 2 μg 11 to 12 Days
$230.67
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Détails

MLLT1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,

Plus protéines pour Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 1 (MLLT1) partenaires d'interaction

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 1 (MLLT1) interaction partners

  1. This review will not only provide a fundamental understanding of the structure and function of ENL and update on the roles of ENL in acute myeloid leukemia, but also the development of new therapeutic strategies

  2. data identify ENL as a histone acetylation reader that regulates oncogenic transcriptional programs in acute myeloid leukaemia, and suggest that displacement of ENL from chromatin may be a promising epigenetic therapy, alone or in combination with BET inhibitors, for aggressive leukaemia

  3. MLL-ENL dysregulated the proliferative and repopulating capacity of hematopoietic stem cells.

  4. Recurrent mutations within Wilms tumours involve the highly conserved YEATS domain of MLLT1.

  5. Novel splice isoform of Mllt1 is documented and confirmed that both Mllt1 mRNA isoforms are translated. The data support that MLLT1 protein isoforms display distinct stage-specific expression during spermiogenesis and adult tissues.

  6. Data suggest that AT mutated protein ATM-dependent phosphorylation of ENL (MLLT1) protein functions as switch from elongation to Polycomb-mediated repression to preserve genome integrity.

  7. AF9 and its homolog ENL directly interact with AF4.

  8. MLL-ENL Interaction with CBX8 Is Required for Efficient Transformation.

  9. Data from a follow-up study in Rome suggest a particularly favorable prognosis for patients with acute lymphoblastic leukemia expressing the MLL/ENL fusion gene.

  10. Three-way translocation involving MLL, MLLT1, and a novel third partner, NRXN1, in a patient with acute lymphoblastic leukemia and t(2;19;11) (p12;p13.3;q23).

  11. ENL chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.

  12. determination of the relative positions of MLL, AF4 and ENL genes, in two lymphoblastic and two myeloid human cell lines

  13. In acute leukemias with a t(11:19) translocation, 50% of the analyzed breakpoints were within the MLLT1 gene introns. The MLL gene was fused to the intact MLLT1 gene by transcriptional readthrough & a splice event, or by trans-splicing.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 1 (MLLT1) interaction partners

  1. ENL overcomes polycomb silencing through recruitment of PAF1 via the conserved YEATS domain, which recognizes acetylated histone H3.

  2. direct regulation of the stability of MLL1 through its cleavage by taspase1

  3. data identify ENL as a histone acetylation reader that regulates oncogenic transcriptional programs in acute myeloid leukaemia, and suggest that displacement of ENL from chromatin may be a promising epigenetic therapy, alone or in combination with BET inhibitors, for aggressive leukaemia

  4. define a specific pairing of two amino acids that creates a salt bridge between MLLT1/3 and AFF proteins that is critically important for MLL-mediated transformation of HPCs

  5. characterization of gene structure, mapping to chromosome 17, and demonstration of an essential role in embryonic development

  6. demonstrate BAM11 transcriptional co-activation activity and its functional interaction with Btk

  7. An intimate association between MLL and RNA pol II occurs at MLL target genes in vivo that is required for normal initiation and/or transcriptional elongation.

  8. Overlapping expression of Af9 with Af4/Aff1 and Fmr2/Aff2, two genes that are also related to neurodevelopmental diseases, as well as with the highly homologous Enl.

  9. Even genetically complex leukemias can be reversed on inactivation of the initiating MLL fusion.

Profil protéine MLLT1

Profil protéine

Capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells.

Gene names and symbols associated with MLLT1

  • MLLT1, super elongation complex subunit (Mllt1)
  • MLLT1, super elongation complex subunit (MLLT1)
  • myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 L homeolog (mllt1.L)
  • myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mllt1)
  • myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (Mllt1)
  • AA407901 Protéine
  • BAM11 Protéine
  • ENL Protéine
  • LTG19 Protéine
  • MGC84026 Protéine
  • MLLT1 Protéine
  • YEATS1 Protéine

Protein level used designations for MLLT1

myeloid/lymphoid or mixed lineage leukemia translocation to 1 homolog , myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog , protein ENL , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 1 , ENL/MLL fusion , MLLT1/MLL fusion , YEATS domain-containing protein 1 , leukemia-associated protein MLLT1 , myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog , trithorax

GENE ID SPECIES
301119 Rattus norvegicus
420089 Gallus gallus
447347 Xenopus laevis
485023 Canis lupus familiaris
504458 Bos taurus
702105 Macaca mulatta
740990 Pan troglodytes
100019539 Monodelphis domestica
100065400 Equus caballus
100158574 Xenopus (Silurana) tropicalis
4298 Homo sapiens
64144 Mus musculus
Fournisseurs de qualité sélectionnés pour MLLT1 Protéines (MLLT1)
Avez-vous cherché autre chose?