anti-Myocilin (MYOC) Anticorps

MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. De plus, nous expédions Myocilin Protéines (23) et Myocilin Kits (7) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
MYOC 17926 O70624
MYOC 4653 Q99972
MYOC 81523 Q9R1J4
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Showing 10 out of 58 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Cobaye Lapin Inconjugué WB 100 μL Connectez-vous pour afficher 2 to 3 Days
Humain Lapin Inconjugué EIA, IHC (p) 50 μg Connectez-vous pour afficher 6 to 8 Days
Humain Souris Inconjugué ELISA, IHC, IP, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) . Dilution: 1:500~1000 50 μg Connectez-vous pour afficher 8 to 11 Days
Humain Lapin Inconjugué ELISA, IHC (p) Immunohistochemistry-Paraffin: Myocilin Antibody [NBP1-40064] - Analysis of anti-MYOC antibody with human eye, retina at concentration 5 ug/ml. 0.05 mg Connectez-vous pour afficher 10 to 13 Days
Humain Lapin Inconjugué ELISA, IHC, WB Western blot analysis of extracts of human heart tissue, using MYOC antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276746 at 1/100 staining Mouse muscle tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Connectez-vous pour afficher 11 to 12 Days
Humain Souris Inconjugué EIA, IHC (p), WB 50 μg Connectez-vous pour afficher 6 to 8 Days
Souris Lapin Inconjugué IHC, WB Western blot analysis of extracts of various cell lines, using MYOC antibody. 100 μL Connectez-vous pour afficher 13 to 14 Days
Humain Lapin Inconjugué ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Human Lung Tissue; Lane2: Human Heart Tissue. 100 μg Connectez-vous pour afficher 13 to 16 Days
Humain Souris Inconjugué ELISA, IHC, IHC (p), RNAi, WB Human Vessel: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Connectez-vous pour afficher 11 to 14 Days
Humain Souris Inconjugué IHC (p), IP, RNAi, ELISA, WB Immunoperoxidase of monoclonal antibody to MYOC on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml] Detection limit for recombinant GST tagged MYOC is approximately 0.3ng/ml as a capture antibody. 50 μg Connectez-vous pour afficher 11 to 12 Days

Plus d’anticorps contre Myocilin partenaires d’interaction

Mouse (Murine) Myocilin (MYOC) interaction partners

  1. mutant myocilin induces abnormal ECM (Montrer MMRN1 Anticorps) accumulation in the ER of TM cells, which may be responsible for reduced outflow facility and IOP elevation in myocilin-associated glaucoma.

  2. Mutated myocilin and heterozygous Sod2 (Montrer SOD2 Anticorps) deficiency act synergistically in a mouse model of open-angle glaucoma

  3. myocilin promotes cell proliferation and resistance to apoptosis via the ERK1/2 MAPK (Montrer MAPK1 Anticorps) signaling pathway.

  4. Myocilin binds to ErbB2 (Montrer ERBB2 Anticorps)/ErbB3 (Montrer ERBB3 Anticorps), activates these receptors, and affects the downstream PI3K-AKT (Montrer AKT1 Anticorps) signaling pathway

  5. Myocilin also stimulated osteogenic differentiation of wild-type MSCs, which was associated with activation of the p38 (Montrer CRK Anticorps), Erk1/2, and JNK (Montrer MAPK8 Anticorps) MAP kinase (Montrer MAPK1 Anticorps) signaling pathways

  6. We suggest that intracellular myocilin plays a role as a regulator of muscle hypertrophy pathways, acting through the components of dystrophin (Montrer DMD Anticorps) associated protein complex.

  7. The TIGR is implicated in resistance to oxidative stress. Despite the presence of a SOD motif, which is necessary for protection in mammalian cells, the protein is not a functional SOD, but might be involved in SOD activity.

  8. TIGR is a newly identified component of the CNS glial scar that is likely to contribute to neuronal regenerative failure characteristic of the mammalian CNS.

  9. Results do not support a causative role for increased MYOC levels or the MYOC gene in steroid-induced glaucoma.

  10. Results show that myocilin and gamma-synuclein interact and as a result, myocilin's properties are changed.

Human Myocilin (MYOC) interaction partners

  1. Structure and misfolding of the flexible tripartite coiled-coil domain of glaucoma-associated myocilin has been reported.

  2. single nucleotide polymorphism in exon 3 of MYOC is associated with glaucoma.

  3. Juvenile onset open angle glaucoma and adult onset POAG form a spectrum of phenotypes. we analyzed the common variants in MYOC and CYP1B1 (Montrer CYP1B1 Anticorps) that were shared among all the three phenotypes .An interesting finding was that, while, many CYP1B1 (Montrer CYP1B1 Anticorps) variants were found in all three types of glaucoma, there was no reported MYOC variant, that was common to all the three primary glaucomas.

  4. present work reveals that FOXC1 (Montrer FOXC1 Anticorps) is an important regulator of exocytosis and establishes a new link between FOXC1 (Montrer FOXC1 Anticorps) and MYOC-associated glaucoma

  5. The four detected MYOC mutations appeared to be associated with morphologic changes in the trabecular meshwork and the underlying pathogenesis of a subtype of familial primary open angle glaucoma.

  6. The mutations c.1456C < T (p.L486F) in MYOC and c.322G < A (p.V108I) in B4GALT3 (Montrer B4GALT3 Anticorps) are likely responsible for the pathogenesis of Primary Open-angle Glaucoma in this family.

  7. Our findings demonstrated that MYOC cascade genetic testing for POAG allows identification of at-risk individuals at an early stage or even before signs of glaucoma are present. To our knowledge, this is the first study to demonstrate the clinical utility of predictive genetic testing for MYOC glaucoma.

  8. regulation by retinoic acid acts through the MYOC promoter which contains a critical cluster of four retinoic acid responsive (Montrer GPRC5A Anticorps) elements (RAREs), with the RARE-DR2 presenting the strongest effect and binding the RARalpha (Montrer RARA Anticorps)/RXRalpha (Montrer RXRA Anticorps) heterodimer.

  9. Five out of 30 families with PCG (16.7%) had disease attributable to CYP1B1 (Montrer CYP1B1 Anticorps) alterations suggesting that CYP1B1 (Montrer CYP1B1 Anticorps) is not the major gene causing PCG in Vietnamese unlike in the case of Arab or Romany patients.

  10. The present study provides insight into the genetic or haplotype variants of MYOC and OPTN (Montrer OPTN Anticorps) genes contributing to primary glaucoma. Haplotype variants identified in the present study may be regarded as potential contributing factors of primary glaucoma in Korea.

Cow (Bovine) Myocilin (MYOC) interaction partners

  1. endoproteolytic processing might regulate the activity of myocilin; the inhibition of the processing by pathogenic mutations impairs the normal role of myocilin

Myocilin (MYOC) profil antigène

Profil protéine

MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.

Gene names and symbols associated with anti-Myocilin (MYOC) Anticorps

  • myocilin (MYOC) anticorps
  • myocilin (myoc) anticorps
  • myocilin (Myoc) anticorps
  • AI957332 anticorps
  • GLC1A anticorps
  • GPOA anticorps
  • JOAG anticorps
  • JOAG1 anticorps
  • MGC136645 anticorps
  • MYOC anticorps
  • myocilin anticorps
  • Tigr anticorps
  • zgc:136645 anticorps

Protein level used designations for anti-Myocilin (MYOC) Anticorps

myocilin , trabecular meshwork-induced glucocorticoid response protein , mutated trabecular meshwork-induced glucocorticoid response protein

397046 Sus scrofa
548602 Danio rerio
704406 Macaca mulatta
17926 Mus musculus
4653 Homo sapiens
81523 Rattus norvegicus
281342 Bos taurus
101087632 Felis catus
490344 Canis lupus familiaris
100008897 Oryctolagus cuniculus
Fournisseurs de qualité sélectionnés pour anti-Myocilin (MYOC) Anticorps
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