Myocyte Enhancer Factor 2B Protéines (MEF2B)

The product of MEF2B is a member of the MADS/MEF2 family of DNA binding proteins. De plus, nous expédions Myocyte Enhancer Factor 2B Anticorps (51) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MEF2B 17259  
Rat MEF2B MEF2B 498607  
MEF2B 100271849 Q02080
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Showing 4 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Détails
Wheat germ Humain GST tag 10 μg 11 to 12 Days
$340.00
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Détails

MEF2B Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human , ,
, ,

Plus protéines pour Myocyte Enhancer Factor 2B (MEF2B) partenaires d'interaction

Zebrafish Myocyte Enhancer Factor 2B (MEF2B) interaction partners

  1. Mef2 controls skeletal muscle formation after terminal differentiation.

Mouse (Murine) Myocyte Enhancer Factor 2B (MEF2B) interaction partners

  1. Mef2b deletion reduces germinal center (GC) formation in mice and identify MEF2B transcriptional targets in GC, with roles in cell proliferation, apoptosis, GC confinement, and differentiation. The most common lymphoma-associated MEF2B mutant (MEF2BD83V) is hypomorphic yet escapes binding and negative regulation by components of the HUCA complex and class IIa HDACs.

  2. Whereas MEF2A is absolutely required for proper myoblast differentiation, MEF2B, -C, and -D were found to be dispensable for this process.

  3. Calcineurein regulates skeletal muscle differentiation by activating MEF2 and MyoD transcription factors.

  4. Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo

Human Myocyte Enhancer Factor 2B (MEF2B) interaction partners

  1. Mef2b deletion reduces germinal center (GC) formation in mice and identify MEF2B transcriptional targets in GC, with roles in cell proliferation, apoptosis, GC confinement, and differentiation. The most common lymphoma-associated MEF2B mutant (MEF2BD83V) is hypomorphic yet escapes binding and negative regulation by components of the HUCA complex and class IIa HDACs.

  2. Although the mechanisms by which the D83V mutation in MEF2B promote oncogenesis in lymphoma cells remain to be elucidated, the observation that a mutation hotspot coincides with a conformation switch site on MEF2B reflects a remarkable convergence of tumor growth selection pressure and the physical/ chemical forces behind protein folding.

  3. The Apo structure of MEF2B reveals a largely preformed DNA binding interface that may be important for recognizing the shape of DNA from the minor groove side.

  4. MEF2B shows superior sensitivity and specificity than LMO2 and HGAL in the differential diagnosis of follicular lymphoma versus marginal zone lymphoma and is particularly useful in FL with plasmacytoid differentiation, which may have morphologic and immunophenotypic overlap with MZL.

  5. Expression of J chain immunoglobulin and MEF2B are useful in differentiating classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.

  6. K4E, Y69H and D83V mutations decrease the capacity of MEF2B to activate transcription and decrease its effects on cell migration.

  7. Epstein-Barr Virus EBNA1 bound to host genes of high significance for B-cell growth and function, including MEF2B, IL6R, and EBF1.

  8. We conclude that MEF2B is a valuable marker of normal germinal center B cells, potentially useful in differential diagnosis of small B cell lymphomas.

  9. MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma.

  10. MEF2B has a role in myogenic transformation of the epithelial to a myofibroblast phenotype

  11. The phylogenetic tree result shows that MEF2B may be original because of its difference of sequences and evolutional relation.

  12. 32% of diffuse large B-cell lymphoma and 89% of follicular lymphoma cases had somatic mutations in MLL2, and 11.4% and 13.4% of DLBCL and FL cases, respectively, had mutations in MEF2B

  13. Crystal structure of the MADS-box/MEF2S domain of human MEF2B bound to a motif of the transcriptional co-repressor Cabin1 and DNA at 2.2 A resolution

  14. myogenin and myocyte enhancer factor-2 expression are triggered by membrane hyperpolarization during human myoblast differentiation

  15. The crystal structure of a histone deacetylase 9 (HDAC9)/myocyte enhancer factor-2 (MEF2)/DNA complex reveals that HDAC9 binds to a hydrophobic groove of the MEF2 dimer.

  16. Study demonstrates that human intestinal cell BCMO1 expression is dependent on the functional cooperation between peroxisome proliferator-activated receptor-gamma and myocyte enhancer factor 2 isoforms.

  17. MEF2 proteins are an important component in Galpha13-mediated angiogenesis.

Cow (Bovine) Myocyte Enhancer Factor 2B (MEF2B) interaction partners

  1. This study provides new evidence of the significant role played by Mef2B in the postnatal muscle growth and development in cattle, and indicates that Mef2B can be a promising molecular marker for carcass quality-related traits in adult cattle.

Profil protéine Myocyte Enhancer Factor 2B (MEF2B)

Profil protéine

The product of this gene is a member of the MADS/MEF2 family of DNA binding proteins. The protein is thought to regulate gene expression, including expression of the smooth muscle myosin heavy chain gene. This region undergoes considerable alternative splicing, with transcripts supporting two non-overlapping loci (geneID:729991 and 100271849) as well as numerous read-through transcripts that span both loci (annotated as geneID:4207). Several isoforms of this protein are expressed from either this locus or from some of the read-through transcripts annotated on geneID:4207.

Gene names and symbols associated with MEF2B

  • myocyte enhancer factor 2b (mef2b)
  • myocyte enhancer factor 2B (MEF2B)
  • myocyte enhancer factor 2B (Mef2b)
  • AI451606 Protéine
  • RSRFR2 Protéine
  • si:ch211-125m10.1 Protéine

Protein level used designations for MEF2B

myocyte-specific enhancer factor 2B , MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B) , serum response factor-like protein 2

GENE ID SPECIES
558073 Danio rerio
609739 Canis lupus familiaris
100568307 Pongo abelii
100568437 Macaca mulatta
17259 Mus musculus
498607 Rattus norvegicus
100271849 Homo sapiens
733675 Sus scrofa
100271851 Bos taurus
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