Myosin Heavy Chain 2, Skeletal Muscle, Adult Protéines (MYH2)

Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. De plus, nous expédions MYH2 Anticorps (30) et MYH2 Kits (22) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
Rat MYH2 MYH2 691644  
MYH2 4620 Q9UKX2
MYH2 17882  
Comment commander chez anticorps-enligne
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Commandez enligne
  • orders@anticorps-enligne.fr

Top MYH2 Protéines sur anticorps-enligne.fr

Showing 3 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Escherichia coli (E. coli) Souris His tag,GST tag 100 μg 15 to 18 Days
$707.00
Détails
Escherichia coli (E. coli) Humain His tag,GST tag   50 μg 15 to 18 Days
$406.00
Détails
Escherichia coli (E. coli) Humain Inconjugué   100 μg 11 to 18 Days
$668.03
Détails

MYH2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human

Mouse (Murine)

Plus protéines pour Myosin Heavy Chain 2, Skeletal Muscle, Adult (MYH2) partenaires d'interaction

Human Myosin Heavy Chain 2, Skeletal Muscle, Adult (MYH2) interaction partners

  1. Exome analysis revealed homozygosity for a novel truncating mutation p.G800fs27* in the Myosin Heavy Chain 2 (MYH2) gene in both brothers, while parents and an unaffected sibling were heterozygous

  2. differential regulation of PKA and cell stiffness in unconfined versus confined cells is abrogated by dual, but not individual, inhibition of Piezo1 and myosin II.

  3. C-terminal Myosin IIA Heavy Chain phosphorylation sites are critical for recruitment of Myosin IIA to lamellar protrusions and for marginal paxillin phosphorylation during active cell spreading.

  4. Transcriptional levels of MHC-I, MHC-IIa, and MHC-IIb in denervation groups were significantly down-regulated compared with controls

  5. Myosin isoforms impact single-fiber force generation and may lead to alterations in whole skeletal muscle performance.

  6. Data shoe that five of the patients were homozygous for myosin heavy chain 2 (MYH2) missense mutations, one patient was compound heterozygous for a missense and a nonsense mutation and one patient was homozygous for a frame-shift MYH2 mutation.

  7. We have found that a greater MyH2 content in the vastus lateralis is accompanied by a higher oxygen cost of cycling during exercise performed below the lactate threshold.

  8. This study presented more case in MYH2 mutation in recessive myopathy with external ophthalmoplegia linked to chromosome 17p13.1-p12.

  9. A previously unrecognized interplay between actin and myosin IIA in podosomes, is demonstrated.

  10. Myosin heavy chain 2A transcripts decreased significantly in skeletal muscle tissue from overnight parenterally fed patients but did not change significantly in orally refed mice

  11. Phenotypic expression of alpha-smooth muscle actin, smooth muscle myosin heavy chain 2, and smoothelin were significantly decreased in the dissected media, whereas that of osteopontin was elevated.

  12. This study demonistrated that the missense mutation c.2542T>C (p.V805A) in the MYHC2A gene.

  13. The human genioglossus muscle is composed of conventional myosin heavy chain isoforms and 3 primary myosin hevy chain phenotypes.

  14. the expression levels of the MHC genes are associated with age and both PGC-1alpha and PGC-1beta and indicate that the MHC genes may to some extent be used to determine fibre-type composition in human skeletal muscle.

  15. NMMII and actin isoform expression changes coordinately with the remodeling phase of repair, and NMMII is increased as matrix stiffness increases. As NMMII expression increases, so does the fibroblast contractility.

  16. Null mutations in the fast myosin heavy chain IIa gene cause early onset myopathy and demonstrate that this isoform is necessary for normal muscle development and function.

  17. investigated the relation between expression of the mutant MyHC IIa and pathologic changes in muscle

  18. Data suggest that changes in intracellular calcium may play a role in shifts in myosin heavy chain IIa (MyHC IIa) expression during muscle activation.

  19. IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression in cell differentiation

  20. analysis of normal variation indicates that there is strong selective pressure against mutations in MYH2; On the basis of these results, we suggest that MyHC genes should be regarded as candidate genes in hereditary myopathies of unknown etiology.

Mouse (Murine) Myosin Heavy Chain 2, Skeletal Muscle, Adult (MYH2) interaction partners

  1. nonmuscle myosin 2A replacement with myosin 2C1 permits gastrulation but not placenta vascular development in mice

  2. Inhibition of myosin IIA decreases annexin 1 nuclear translocation in oxygen-glucose deprivation.

  3. Myh2 expression was significantly higher in ESCs-mechanical group than that in the same group of MSCs.

  4. Activated T cell trans-endothelial migration relies on myosin-IIA contractility for squeezing the cell nucleus through endothelial cell barriers.

  5. Myosin IIa has a role in upregulating early osteogenesis

  6. Myosin heavy chain 2A transcripts decreased significantly in skeletal muscle tissue from overnight parenterally fed patients but did not change significantly in orally refed mice

  7. Increase of CYP1A1-mRNA was due to nonmuscle myosin II inhibition.

  8. Calcium-mediated dephosphorylation of dynamin I at Ser-774 leads to the recruitment of the molecular motor myosin II to actively dilate the fusion pore to facilitate release of peptide transmitters.

  9. GADD34 negatively regulates cell migration in wound healing via expression of myosin IIA.

  10. Data suggest that changes in intracellular calcium may play a role in shifts in myosin heavy chain IIa (MyHC IIa) expression during muscle activation.

  11. conventional myosin motor, myosin IIA, drives neurite retraction.

  12. In myotonic fast muscles, hyperexcitability leads to a drastic reduction of MyHC IIB which is compensated by IIA.

  13. mice ablated for NMHC II-A fail to develop a normal patterned embryo with a polarized visceral endoderm; defects in cell adhesion and tissue organization are explained by loss of E-cadherin and beta-catenin localization to cell adhesion sites

  14. IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression in cell differentiation

  15. Both myosin IIA and myosin IIB are localized in nerve terminals.

  16. Data suggest that non-muscle myosin 2A is important for bipolar shape formation and adhesion owing to its preferential interaction with membrane-associated actin, and the role myosin 2B in retraction prevents over-elongation of myoblasts.

  17. replacement with oe Mysin 2A with myosin IIB rescues brain from hydrocephalus and manttains integrity of the spinal canal.

  18. Regulation of Myosin-IIA function in T cells is thus a key mechanism to regulate surface contact area and crawling velocity within different environments

Profil protéine MYH2

Profil protéine

Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene names and symbols associated with MYH2

  • myosin, heavy chain 2, skeletal muscle, adult (MYH2)
  • myosin heavy chain 2 (Myh2)
  • myosin heavy chain 2 (MYH2)
  • myosin, heavy polypeptide 2, skeletal muscle, adult (Myh2)
  • MHC2A Protéine
  • Myh1 Protéine
  • MYH2A Protéine
  • MYHas8 Protéine
  • MYHC-2A Protéine
  • MyHC-IIa Protéine
  • Myhs-f Protéine
  • Myhs-f1 Protéine
  • MYHSA2 Protéine
  • Myhsf1 Protéine

Protein level used designations for MYH2

myosin, heavy chain 2, skeletal muscle, adult , myosin, heavy polypeptide 2, skeletal muscle, adult , 2A myosin heavy chain , myosin heavy chain IIa , myosin heavy chain type IIx , fast 2a myosin heavy chain , myosin heavy chain 2 , myosin heavy chain 2a , myosin heavy chain, skeletal muscle, adult 2 , myosin-2 , type IIA myosin heavy chain , type 2a myosin heavy chain , fast myosin heavy chain 2A , myHC-2a , myosin heavy chain 2A , skeletal muscle myosin heavy chain II-a

GENE ID SPECIES
100009054 Oryctolagus cuniculus
691644 Rattus norvegicus
4620 Homo sapiens
788772 Bos taurus
608242 Canis lupus familiaris
791236 Equus caballus
397256 Sus scrofa
17882 Mus musculus
Fournisseurs de qualité sélectionnés pour MYH2 Protéines (MYH2)
Avez-vous cherché autre chose?