Myosin Light Chain Kinase Protéines (MYLK)

MYLK, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. De plus, nous expédions Myosin Light Chain Kinase Anticorps (129) et Myosin Light Chain Kinase Kits (39) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MYLK 4638 Q15746
MYLK 288057  
MYLK 107589  
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Showing 10 out of 14 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Escherichia coli (E. coli) Souris His tag,T7 tag 100 μg Connectez-vous pour afficher 15 to 18 Days
Escherichia coli (E. coli) Humain His tag 100 μg Connectez-vous pour afficher 15 to 18 Days
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
Levure Sanglier His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
Levure Mouton His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
Cellules d'insectes Humain GST tag 5 μg Connectez-vous pour afficher 11 to 12 Days
Baculovirus infected Insect Cells Humain GST tag   5 μg Connectez-vous pour afficher 10 to 12 Days
Cellules d'insectes Humain GST tag   10 μg Connectez-vous pour afficher 3 to 4 Days
Escherichia coli (E. coli) Rat Inconjugué   100 μg Connectez-vous pour afficher 11 to 18 Days

MYLK Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , , ,
, ,
Rat (Rattus)
Mouse (Murine)

Plus protéines pour Myosin Light Chain Kinase (MYLK) partenaires d'interaction

Human Myosin Light Chain Kinase (MYLK) interaction partners

  1. These data further define the aortic phenotype associated with MYLK pathogenic variants. Given minimal aortic enlargement before dissection, an alternative approach to guide the timing of aortic repair is proposed based on the probability of a dissection at a given age

  2. This study found that MYLK gene Ala1491Ser mutation affect the kinase activity and clinically, it presents with vascular aneurysms and dissection.

  3. miR155 directly suppressed the expression of MYLK without affecting the RhoA pathway.

  4. the MAPKspecific inhibitor SB203580 attenuated the inhibitory effects of 4HPR on the migration of HepG2 cells. Moreover, we also observed that 4HPR inhibited the activation and expression of myosin light chain kinase (MLCK) in HepG2 cells.

  5. Recombinant human MLCK was concentration- and time-dependently degraded by recombinant human MMP9 in vitro, and this process was prevented by the MMP9 inhibitor.

  6. High expression of MLCK is correlated with metastatic triple negative breast cancer.

  7. Interaction between kinase domain and regulatory light chain (RLC) substrate is identified in the absence of calmodulin, indicating restored substrate-binding capability due to mechanically induced removal of the auto-inhibitory regulatory region.

  8. loss of MLCK contributes to the migratory properties of epithelial cells resulting from changes in cell-cell and cell-matrix adhesions, and increased epidermal growth factor receptor signaling.

  9. Its phosphorylation and dephosphorylation regulate smooth muscle contraction and relaxation.

  10. Sixty-seven experienced runners competed in a marathon race. The MLCK genotype (C37885A) of these marathoners was determined. CA heterozygotes for MLCK C37885A might present higher exercise-induced muscle damage after a marathon competition than CC counterparts.

  11. three Megacystis microcolon intestinal hypoperistalsis syndrome (MMHS)-affected subjects from two consanguineous families with no variants in the known MMIHS-associated genes.

  12. these Acute respiratory distress syndrome (ARDS)-associated MYLK cytosine-guanine dinucleotides with effect modification by ethnicity and local modified cytosine quantitative trait loci suggest that MYLK epigenetic variation and local genetic background may contribute to health disparities observed in ARDS.

  13. mechanical stress and MYLK single nucleotide polymorphism regulate MYLK alternative splicing.

  14. Rebeccamycin attenuates TNF-alpha-induced disruption of intestinal epithelial barrier integrity by inducing claudin-5 expression and suppressing MLCK production via Chk1 activation.

  15. Data show that alterations in myosin light chain kinase activity, claudin-15 and claudin-2 expression are associated with gluten-induced symptomatology and intestinal permeability changes in diarrhea-predominant irritable bowel syndrome (IBS-D).

  16. PXR regulates the intestinal epithelial barrier during inflammation by modulating cytokine-induced MLCK expression and JNK1/2 activation

  17. A 2-bp deletion in myosin light chain kinase (c3272_3273del, p.Ser1091*) that led to a premature stop codon have a high risk of presenting with an acute aortic dissection or rupture.

  18. In contrast to mylk2 and mylk3, mylk1 has a complex structure, and multiple protein products of the mylk1 gene are expressed in most if not all cell types. This review deals with the mylk1 gene and its protein products- multiple MLCK isoforms and noncatalytic KRP/telokin protein. [Review]

  19. Likely pathogenic variants included a TGFB2 variant in one patient and a SMAD3 variant in another. These variants have been reported previously in individuals with similar phenotypes. Variants of uncertain significance of particular interest included novel variants in MYLK and MFAP5, which were identified in a third patient

  20. suggest a novel role for myosin light chain and myosin light chain kinase in advanced glycation end product-induced endothelial hyperpermeability

Cow (Bovine) Myosin Light Chain Kinase (MYLK) interaction partners

  1. Histamine induces myosin light chain (MLC)phosphorylation via MYLK, suggesting regulatory role for MLC in controlling corneal epithelial permeability.

Rabbit Myosin Light Chain Kinase (MYLK) interaction partners

  1. evaluated the spatial arrangement of the catalytic/regulatory domain, three immunoglobulin-related motifs, one fibronectin-related motif, a repetitive, proline-rich segment, and, at the N-terminus, a unique F-actin-binding domain.

Mouse (Murine) Myosin Light Chain Kinase (MYLK) interaction partners

  1. telokin may play a role in attenuating constitutive myosin light chain phosphorylation

  2. MLCK is linked to timely blastocyst formation, though it is dispensable for oocyte meiotic maturation

  3. NF-kappaB novel partner within endothelial cells

  4. MLCK regulates cell migration in a myosin regulatory light chain phosphorylation-independent mechanism.

  5. nmMlck modulates IL-1beta-mediated downregulation of Cldn5 in brain microvascular endothelial cells.

  6. This study provides the first prognostic cancer gene signature derived from a murine model of nmMLCK-associated lung inflammation. Activation of nmMLCK-involved pathways contributes to tumor growth and progression in human cancers.

  7. They also suggest a molecular pathomechanism of hypertrophic cardiomyopathy caused by hVLC-1 mutations.

  8. a prominent effect of the multifunctional microRNA-155 in endothelial cells is modulation of phenotype through alterations in RhoA, myosin light chain kinase expression, and actin cytoskeleton organization

  9. CArG element in intron 15 of the mylk1 gene is necessary for maximal expression of the 130-kDa smMLCK and that the 130-kDa smMLCK isoform is specifically required to regulate smooth muscle contractility

  10. In immune-mediated inflammatory bowel disease, tight junction dysregulation and barrier loss is induced by MLCK, but at advanced stages, barrier loss is MLCK-independent.

  11. Claudin-2 assumes an important role in colorectal inflammation, and furthermore implicates the involvement of MLCK in colon inflammation.

  12. involved in IL-1beta-induced increase in intestinal permeability

  13. These data suggest that myosin light-chain kinase activity may promote morphological and inflammatory responses in the ileum following ethanol exposure and burn injury.

  14. Molecular mechanism of telokin-mediated disinhibition of myosin light chain phosphatase and cAMP/cGMP-induced relaxation of gastrointestinal smooth muscle.

  15. Myosin light-chain kinase is necessary for maintaining the membrane stability of inner hair cells.

  16. Deletion of MLCK restored intestinal barrier function in STAT5 knockout mice, and facilitated mucosal wound healing(MLCK)

  17. MLCK is essential for the translocation and association of cortactin and p47phox.

  18. Report role of vascular smooth muscle myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension.

  19. The results demonstrate that skMLCK catalyzed RLC phosphorylation augments isometric twitch force during moderate, but not severe, levels of fatigue.

  20. Phosphorylation of MEF2C on threonine80 by skeletal myosin light chain kinase (MLCK) enhances skeletal and not cardiac myogenesis.

Zebrafish Myosin Light Chain Kinase (MYLK) interaction partners

  1. Conclude that Mlck1a is the subtype of MLCK that contributes to platelet shape change and thrombus formation.

Profil protéine Myosin Light Chain Kinase (MYLK)

Profil protéine

This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.

Gene names and symbols associated with MYLK

  • myosin light chain kinase (MYLK)
  • myosin light chain kinase (Mylk)
  • myosin, light polypeptide kinase (Mylk)
  • myosin, light chain kinase a (mylka)
  • 9530072E15Rik Protéine
  • A930019C19Rik Protéine
  • AAT7 Protéine
  • AW489456 Protéine
  • fj60a06 Protéine
  • KRP Protéine
  • mlck Protéine
  • MLCK1 Protéine
  • mlck1a Protéine
  • MLCK108 Protéine
  • MLCK210 Protéine
  • MSTP083 Protéine
  • mylk Protéine
  • MYLK1 Protéine
  • SMMLCK Protéine
  • wu:fj60a06 Protéine
  • zmlck1 Protéine

Protein level used designations for MYLK

kinase-related protein , myosin light chain kinase, smooth muscle , myosin, light polypeptide kinase , smooth muscle myosin light chain kinase , telokin , kinase related protein, telokin , myosin, light chain kinase , MLCK , myosin light chain kinase , myosin light chain kinase, smooth muscle-like , smooth muscle myosin light chain kinase (61-kDa active fragment) , myosin light chain kinase 1 , smooth muscle MLCK

4638 Homo sapiens
288057 Rattus norvegicus
338037 Bos taurus
460640 Pan troglodytes
488012 Canis lupus familiaris
715422 Macaca mulatta
100009143 Oryctolagus cuniculus
100481263 Ailuropoda melanoleuca
107589 Mus musculus
396445 Gallus gallus
396848 Sus scrofa
443334 Ovis aries
100714177 Cavia porcellus
569510 Danio rerio
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