N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) Protéines (NAT2)

NAT2 encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. De plus, nous expédions NAT2 Anticorps (72) et NAT2 Kits (7) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
NAT2 10 P11245
NAT2 17961 P50295
NAT2 116632 P50298
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Showing 8 out of 11 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,370.21
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$340.00
Détails
Escherichia coli (E. coli) Rat Inconjugué SDS-PAGE analysis of Rat NAT2 Protein. 100 μg Connectez-vous pour afficher 11 to 18 Days
$668.03
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,764.67
Détails
Levure Macaque rhésus His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,764.67
Détails
Levure Lapin His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,764.67
Détails
Levure Hamsters dorés syriens His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,764.67
Détails

NAT2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Rat (Rattus) ,
,

Plus protéines pour N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2) partenaires d'interaction

Human N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2) interaction partners

  1. Results indicate that haplotypes that provide rapid N-acetyltransferase 1 (NAT1) and slow N-acetyltransferase 2 (NAT2) acetylating phenotypes may influence the development of acute lymphoblastic leukemia (ALL) in children.

  2. rs1799929, rs1799930, and rs1799931 polymorphisms of the NAT-2 gene do not appear to be a risk factor for the development of psoriasis. Conversely, they may have an effect on either more severe or early onset cases of the disease.

  3. NAT2 genetic polymorphism predisposes children with connective tissue dysplasia to adhesion ileus.

  4. Data showed that NAT1, NAT2, and ESR1 expression were increased in primary breast tumor tissue and that NAT1 expression was much higher than NAT2. NAT1 and ESR1 expression were strongly associated, whereas NAT2 and ESR1 expression were not. Although NAT1 and NAT2 expression were associated, the magnitude was moderate.

  5. It is concluded that the frequency of slow encoding NAT2 haplotype was high among Jordanian volunteers, which may have effects on drug responses and susceptibility to some diseases, such as cancers.

  6. We report a high prevalence of NAT 2 slow acetylators in Ethiopians and a conditional NAT2 genotype-phenotype country-of-residence-based discordance implicating a partial phenotype conversion and metabolic adaptation. Gene-environment interactions regulate NAT2 phenotype.

  7. NAT2 genetic variants are associated with urinary bladder cancer risk.

  8. Letter: in bladder cancer ultra-slow acetylators with the NAT2*6A/*6A genotype have a higher recurrence risk and a shorter recurrence-free time, especially among smokers.

  9. NAT2 polymorphism is not associated with passive smoking associated breast cancer risk.

  10. NAT2 role in the metabolic detoxification of heterocyclic aromatic amines

  11. hydralazine efficacy and safety could be improved by NAT2 genotype-dependent dosing strategies

  12. Studied the association between N-acetyl transferase 2 (NAT2)genetic polymorphisms, environmental factors and risk factors in colon or rectal cancer.

  13. prevalence impaired glucose tolerance higher in obese children carrying the A803 allele

  14. There were significant differences in NAT2(rs1799929, rs1799930) genotype or allele frequencies between the infertile and fertile groups and synergy effects of GSTP1 and NAT2 polymorphisms might lead to significant increase of infertility risk.

  15. The increased risk of prostate cancer was observed among individuals with the NAT2 slow acetylator phenotype

  16. Genotyping of TB patients from south India for NAT2 gene polymorphism revealed that 58 per cent of the study population comprised slow acetylators. Two-hour INH concentrations differed significantly among the three genotypes.

  17. Slow NAT2 acetylators demonstrated a significant association with risk of anti-tuberculosis drug-induced liver injury in Thai patients.

  18. The present study demonstrated no association between NAT2 genotype and drug-induced hepatotoxicity in the north Indian patients with tuberculosis.

  19. SNP-inferred slow acetylation statuses were significantly associated with an approximately 50% decreased risk of bladder cancer

  20. CYP3A4 expression and N-acetyl transferase 2 acetylator phenotype can better identify the patients with higher risk of adverse reactions and can facilitate the improvement of personalized clonazepam therapy and withdrawal regimen.

Mouse (Murine) N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2) interaction partners

  1. This study illustrated that deficiency of NAT1/2 decreases isoniazid (INH) acetylation, but increases the interactions of INH with endobiotics in the liver.

  2. It was concluded that an acute colonic inflammation impairs the expression and function of NAT2 enzyme, thereby diminishing the capacity for 5-aminosalisylic acid metabolism by colonic mucosa.

  3. Hyperhomocysteinemia-induced decrease of peroxynitrite level is associated with an increase of hepatic Nat2 isoform activity with a reversal effect of wine polyphenol extract supplementation.

  4. Mouse NAT2 is likely to influence epigenetic gene control, particularly of its own locus, and this is consistent with recent evidence associating aberrant mouse Nat2/human NAT1 gene expression with certain developmental malformations and cancers.

  5. Nat2 knockout mouse line demonstrates that different Nat2 isoforms have distinct functions with no compensatory expression, in Nat2 knockout animals, of the other isoforms.

  6. expression and down-regulation of this enzyme complex plays an important role in the generation and differentiation of neurons

  7. Variation in capacity for acetylation of 4ABP and PABA resulting from endogenous murine NAT2 alleles is insufficient to affect 4ABP genotoxicity in liver.

  8. Results suggest that peroxynitrite-dependent inactivation of NAT1 and 2 may contribute to muscle dysfunction by impairing the biotransformation activity of this key cellular defense enzyme system.

  9. These ocular phenotypes and their association with Nat2 genotype indicate that the Nat2 locus may be responsible for the previously described microphthalmic Cat4 phenotype.

  10. study reports the detailed expression of the Nat2 gene and encoded protein in mouse embryos

  11. Mouse N-acetyltransferase-2 was produced as a recombinant protein and found to have a substrate specificity profile similar to human N-acetyltransferase type 1.

Rhesus Monkey N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2) interaction partners

  1. The study is the first to thoroughly characterize the properties of a polymorphic NAT isoenzyme in a non-human primate model.

Profil protéine NAT2

Profil protéine

This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2).

Gene names and symbols associated with NAT2

  • N-acetyltransferase 2 (NAT2)
  • N-acetyltransferase 2 (arylamine N-acetyltransferase) (NAT2)
  • N-acetyltransferase 2 (arylamine N-acetyltransferase) (Nat2)
  • N-acetyltransferase 2 (Nat2)
  • AAC2 Protéine
  • AT-2 Protéine
  • AT-B/AT-II Protéine
  • AT-II Protéine
  • AT2 Protéine
  • AV377607 Protéine
  • NAT Protéine
  • NAT-2 Protéine
  • Nat2a Protéine
  • PNAT Protéine

Protein level used designations for NAT2

N-acetyltransferase type 2 , arylamide acetylase 2 , arylamine N-acetyltransferase 2 , PNAT , lambda R-1 , polymorphic arylamine N-acetyltransferase , N-acetyl transferase 2 , NAT-2 , AT-2 , N-Acetyltransferase-2 (arylamine N-acetyltransferase) , N-acetyltransferase 2 (arylamine N-acetyltransferase) , Arylamide acetylase 2 , NAT2 15 , Polymorphic arylamine N-acetyltransferase , acetyltransferase , arylamine N-acetyltransferase-2

GENE ID SPECIES
10 Homo sapiens
100008974 Oryctolagus cuniculus
17961 Mus musculus
116632 Rattus norvegicus
704357 Macaca mulatta
101840555 Mesocricetus auratus
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