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NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. De plus, nous expédions NMI Protéines (9) et NMI Kits (5) et beaucoup plus de produits pour cette protéine.
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Human Monoclonal NMI Primary Antibody pour IHC (p), ELISA - ABIN522559
Saito, Yukawa, Matozaki, Mikami, Yamagami, Yamagishi, Kuga, Hatayama, Nakayama: Nmi interacts with Hsp105? and enhances the Hsp105?-mediated Hsp70 expression. dans Experimental cell research 2014
results provide new insights into understanding the regulatory mechanism of cancer stem cells and suggest that the NMI (Montrer MYO1C Anticorps)-YY1 (Montrer YY1 Anticorps)-hTERT signaling axis may be a potential therapeutic target for breast cancers.
Damage-associated molecular patterns (DAMP (Montrer AMPH Anticorps)) are important mediators of innate immunity. Here the authors show that N-myc and STAT interactor (NMI) and interferon-induced protein 35 (IFP35 (Montrer IFI35 Anticorps)) act as DAMPs to promote inflammation by activating macrophages via the Toll-like receptor 4 (Montrer TLR4 Anticorps) and NF-kappaB (Montrer NFKB1 Anticorps) pathways.
These investigations demonstrated etoposide-induced NMI (Montrer MYO1C Anticorps) can suppress tumor proliferation and promote cell apoptosis by activating the ARF-p53 (Montrer TP53 Anticorps) signaling pathway in lung carcinoma. Our results provide an alternative mechanism for etoposide in lung carcinoma and suggest NMI (Montrer MYO1C Anticorps) has a critical role in suppressing lung carcinoma progression.
Data suggest that N-myc (and STAT) interactor (NMI) could improve its downstream target bradykinin B2 receptor (BDKRB2) expression to induce extracellular signal-regulated kinases (ERK) 1 (Montrer MAPK3 Anticorps)/2 activation, and thereby further evoke malignant progression of hepatocellular carcinoma (HCC (Montrer FAM126A Anticorps)).
N-Myc (Montrer MYCN Anticorps)-interacting protein (NMI (Montrer MYO1C Anticorps)) negatively regulates epithelial-mesenchymal transition by inhibiting the acetylation of NF-kappaB (Montrer NFKB1 Anticorps)/p65 (Montrer GORASP1 Anticorps) in histone deacetylase (Montrer HDAC1 Anticorps)-dependent manner.
N-myc and STAT interactor sensitizes breast cancer cells to cisplatin treatment through DRAM1 (Montrer DRAM1 Anticorps) dependent autophagy.
Results show that aberrant miR (Montrer MLXIP Anticorps)-29 expression may account for reduced NMI (Montrer MYO1C Anticorps) expression in breast tumors and mesenchymal phenotype of cancer cells that promotes invasive growth.
The results showed that SARS (Montrer SARS Anticorps) coronavirus protein 6 can promote the ubiquitin-dependent proteosomal degradation of Nmi (Montrer MYO1C Anticorps).
overexpression or depletion of NMI (Montrer MYO1C Anticorps) revealed its regulation on G1/S progression and cell proliferation (both in vitro and in vivo), and this effect was partially dependent on STAT1 (Montrer STAT1 Anticorps), which interacted with and was regulated by NMI (Montrer MYO1C Anticorps).
Trim21 (Montrer TRIM21 Anticorps) regulates Nmi (Montrer MYO1C Anticorps)-IFI35 (Montrer IFI35 Anticorps) complex-mediated inhibition of innate antiviral response
These findings suggest that Nmi is a negative regulator of the virus-triggered induction of type I IFNs that targets IRF7 (Montrer IRF7 Anticorps)
NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.
, N-mcy (and STAT) interactor
, N-myc (and STAT) interactor
, N-myc and STAT interactor
, N-myc/STAT interactor