anti-N-Myc Downstream Regulated 1 (NDRG1) Anticorps

NDRG1 is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. De plus, nous expédions N-Myc Downstream Regulated 1 Protéines (17) et N-Myc Downstream Regulated 1 Kits (10) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
NDRG1 10397 Q92597
NDRG1 17988 Q62433
NDRG1 299923 Q6JE36
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Top anti-N-Myc Downstream Regulated 1 Anticorps sur

Showing 10 out of 203 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Chèvre Inconjugué IHC, ELISA, WB ABIN184872 staining (0.1µg/ml) of Human Kidney lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Connectez-vous pour afficher 6 to 7 Days
Humain Souris Inconjugué ELISA, IF, IHC, WB Immunoperoxidase of monoclonal antibody to NDRG1 on formalin-fixed paraffin-embedded human endometrium (antibody concentration 0.7 µg/mL).  Detection limit for recombinant GST tagged NDRG1 is approximately 1 ng/mL as a capture antibody. 100 μg Connectez-vous pour afficher 8 to 11 Days
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-NDRG1 Antibody Titration:  2.5ug/ml  Positive Control:  HepG2 cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
Boeuf (Vache) Lapin Inconjugué IHC, WB WB Suggested Anti-NDRG1 Antibody Titration:  2.5ug/ml  Positive Control:  HepG2 cell lysate Rabbit Anti-NDRG1 Antibody   Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue Observed Staining: Cytoplasmic Primary Antibody Concentration: 1:100 Other Working Concentrations: N/A Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec 100 μL Connectez-vous pour afficher 2 to 3 Days
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: NDRG1 Antibody [NBP1-86636] - Staining of human stomach shows strong cytoplasmic positivity in glandular cells. Western Blot: NDRG1 Antibody [NBP1-86636] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells); Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells). 0.1 mL Connectez-vous pour afficher 10 to 13 Days
Humain Lapin Inconjugué IHC, IHC (p), WB Western Blot: NDRG1 Antibody [NBP1-32074] - A. 30 ug 293T whole cell lysate/extract, B. 30 ug HepG2 whole cell lysate/extract 10 % SDS-PAGE gel, antibody dilution 1:1000. Western Blot: NDRG1 Antibody [NBP1-32074] - Sample (30 ug of whole cell lysate) A:NIH-3T3 10% SDS PAGE diluted at 1:1000. 0.1 mL Connectez-vous pour afficher 8 to 11 Days
Humain Chèvre Inconjugué IHC (p), IHC, ELISA, WB Immunohistochemistry-Paraffin: NDRG1 Antibody [ABIN268580] - (0.5ug/ml) staining of paraffin embedded Human hepatocelluar carcinoma. Data obtained from C. Furer, Visceral Surgery, University of Bern, Switzerland. Western Blot: NDRG1 Antibody [ABIN268580] - staining (1ug/ml) of Human Testis lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 0.1 mg Connectez-vous pour afficher 7 to 9 Days
Humain Lapin Inconjugué WB 100 μg Connectez-vous pour afficher 2 to 3 Days
Humain Lapin Inconjugué FACS, IHC (p), WB Western blot analysis of NDRG1 Antibody (N-term) (ABIN390922) in MDA-MB231 cell line lysates (35 µg/lane). NDRG1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human prostate carcinoma with NDRG1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Connectez-vous pour afficher 10 to 11 Days
Humain Lapin Inconjugué IF, IHC, WB Immunohistochemistry of paraffin-embedded mouse kidney using NDRG1 antibody at dilution of 1:100 (x400 lens). 100 μL Connectez-vous pour afficher 16 Days

anti-N-Myc Downstream Regulated 1 Anticorps mieux référencés

  1. Human Polyclonal NDRG1 Primary Antibody pour ICC, IF - ABIN4338332 : Schilling, Hjelmeland, Radiloff, Liu, Wakeman, Fielhauer, Foster, Lathia, Rich, Wang, Datto: NDRG4 is required for cell cycle progression and survival in glioblastoma cells. dans The Journal of biological chemistry 2009 (PubMed)
    Show all 4 Pubmed References

  2. Arabidopsis thaliana Polyclonal NDRG1 Primary Antibody pour IHC - ABIN966642 : Century, Shapiro, Repetti, Dahlbeck, Holub, Staskawicz: NDR1, a pathogen-induced component required for Arabidopsis disease resistance. dans Science (New York, N.Y.) 1997 (PubMed)
    Show all 2 Pubmed References

  3. Arabidopsis thaliana Polyclonal NDRG1 Primary Antibody pour IHC - ABIN966641 : Coppinger, Repetti, Day, Dahlbeck, Mehlert, Staskawicz: Overexpression of the plasma membrane-localized NDR1 protein results in enhanced bacterial disease resistance in Arabidopsis thaliana. dans The Plant journal : for cell and molecular biology 2004 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal NDRG1 Primary Antibody pour IF, IHC (p) - ABIN564518 : Leth-Larsen, Lund, Hansen, Laenkholm, Tarin, Jensen, Ditzel: Metastasis-related plasma membrane proteins of human breast cancer cells identified by comparative quantitative mass spectrometry. dans Molecular & cellular proteomics : MCP 2009 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal NDRG1 Primary Antibody pour IHC (p), IHC - ABIN268580 : Zhou, Salnikow, Costa: Cap43, a novel gene specifically induced by Ni2+ compounds. dans Cancer research 1998 (PubMed)

  6. Human Polyclonal NDRG1 Primary Antibody pour IHC, IHC (p) - ABIN442051 : Chaudhari, Talwar, Lefebvre Dhellencourt, Ravanan: CDDO and ATRA Instigate Differentiation of IMR32 Human Neuroblastoma Cells. dans Frontiers in molecular neuroscience 2017 (PubMed)

  7. Human Polyclonal NDRG1 Primary Antibody pour FACS, IHC (p) - ABIN390922 : Sugiyama, Masuda, Shinoda, Nakamura, Tomita, Ishihama: Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications. dans Molecular & cellular proteomics : MCP 2007 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre N-Myc Downstream Regulated 1 partenaires d’interaction

Human N-Myc Downstream Regulated 1 (NDRG1) interaction partners

  1. Study suggests that the higher NDRG1 expression may be associated with the radio-resistance of human rectal cancer cells, and it can be a potential therapeutic target for re-sensitizing radio-resistant rectal cancer cells to ionizing radiation.

  2. Findings indicate the regulatory mechanism of microrchidia family CW-type zinc finger 2 (MORC2) in downregulating N-myc downstream-regulated gene 1 protein (NDRG1), and suggest MORC2 as a potential therapeutic target for colorectal cancer (CRC).

  3. These findings indicate that NDRG1 expression is associated with both prognosis and c-Myc expression in lung adenocarcinoma

  4. Meta-analysis showed that low NDRG1 expression was significantly associated with worse survival in colorectal cancer and pancreatic cancer but higher survival of patients with liver cancer and gallbladder cancer. No significant association was observed between low NDRG1 expression and survival in gastric cancer or esophageal cancer.

  5. Findings indicate a positive feedback loop between cancer associated fibroblast (CAFs) and box Q1 (FOXQ1)/N-myc downstream-regulated gene 1 (NDRG1) axis in neoplastic cells to drive hepatocellular carcinoma (HCC) initiation, suggesting new potential therapeutic targets for HCC.

  6. In summary, CAPE attenuates Nasopharyngeal carcinoma (NPC)cell proliferation and invasion by upregulating NDRG1 expression via MAPK pathway and by inhibiting phosphorylation of STAT3. Considering the poor prognosis of NPC patients with metastasis, CAPE could be a promising agent against NPC.

  7. These results indicate the N-terminus region and phosphorylation at Ser330 could be crucial for NDRG1 nuclear localization and function. PTEN silencing indicated that p-NDRG1 (Thr346) could be regulated differentially in different tumor cell-types, indicating PTEN may be involved in the mechanism(s) underlying the pleiotropic activity of NDRG1.

  8. present study shows that HER4 and/or NDRG1 might play a critical role for the cell survival and chemo-resistance of Osteosarcoma (OS), and could be used as potential therapeutic targets in OS.

  9. our study described two homozygous missense mutations in NDRG1 in CMT patients and mentioned the function of NDRG1 in protein recycling, which plays an important role in myelination of the peripheral nerve system.

  10. NDRG1 over-expression promoted apoptosis in colorectal cancer cells whereas depletion of NDRG1 resulted in resistance to oxaliplatin treatment.

  11. HCV coopts the MYC pathway responsible for NDRG1 expression and phosphorylation that regulates lipid droplet formation and metabolism. NDRG1 appears to restrict HCV by suppressing the lipid droplet formation that is necessary for HCV assembly.

  12. these data show that NDRG1 is regulated by the oncogenic MAP kinase-interacting kinase pathway, a target for cancer therapy

  13. The research findings provide novel insights suggesting that loss of N-myc downregulated gene 1 (NDRG1) leads to a decrease in actin-mediated cellular motility but an increase in cellular invasion, resulting in increased tumor dissemination which positively impacts metastatic outcome.

  14. Our experiments revealed that long-term (24 h), but not short-term hypoxia led to the induction of NDRG1 expression in human glioma cell lines. NDRG1 expression was found to correlate with the protein expression of HIF-1alpha, SP1, CEBPalpha, YB-1 and Smad7

  15. Data show that LSD1 affects motility and invasiveness of neuroblastoma cells by modulating the transcription of the metastasis suppressor NDRG1. Mechanistically, results found that LSD1 co-localizes with MYCN at the promoter region of the NDRG1 gene and inhibits its expression.

  16. Compared with the normal term pregnancies, the expression of both NDRG1 mRNA and protein were significantly high in placentas from preeclampsia, and the expression of NDRG1 in early-onset preeclampsia was higher than that in late-onset preeclampsia.

  17. we demonstrated that the novel molecule of cell migration and invasion, caveolin-1, has direct interaction with NDRG1 in human colorectal cancer cells

  18. strong NDRG1 expression in ciliated epithelial cells in nasal tissues sampled from patients with chronic rhinosinusitis. NDRG1 gene knockdown decreased the transepithelial electrical resistance and increased the dextran permeability. NDRG1 knockdown disrupted tight junctions of airway epithelial cells. NDRG1 knockdown significantly decreased only claudin-9 expression, but did not decrease other claudin family molecules.

  19. Study elucidates a mechanism of NDRG1-regulated Wnt pathway activation and EMT via affecting TLE2 and beta-catenin expression in esophageal cancer cells.

  20. NDRG1 prevented the degradation of c-Myc through Skp2-mediated ubiquitination in tumor cells. NDRG1 directly interacted with Skp2, and decreased phosphorylation of Skp2 through inactivation of CDK2.

Mouse (Murine) N-Myc Downstream Regulated 1 (NDRG1) interaction partners

  1. Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop.

  2. NDR1 interacts with TRAF3 and interferes with the association of TRAF3 and IL-17R, resulting in increased formation of the activation complex IL-17R-Act1, which is required for the downstream signaling and production of pro-inflammatory factors

  3. NDR1 kinase, activated by the Rap1 signaling cascade through RAPL and Mst1/Mst2, associated with and recruited kindlin-3 to the immunological synapses, which was required for high-affinity LFA-1/ICAM-1 binding.

  4. Snell, GHKRO, and PAPPA-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT) and N-myc downstream-regulated gene 1 (NDRG1).

  5. NDRG1 deficiency attenuates the differentiation of macrophage lineage cells, suppressing bone remodeling and inflammatory angiogenesis. This study strongly suggests the crucial role of NDRG1 in differentiation process for macrophages.

  6. Using double knockout of NDR1 and 2 shows that NDRs acted downstream of MST1 to mediate the egress of mature thymocytes from the thymus, as well as the interstitial migration of naive T cells within popliteal lymph nodes.

  7. Ndrg1 is phosphorylated and degraded by CD28 signalling in a proteasome-dependent manner.

  8. Ndr1/2-double null embryos show defects in somitogenesis and cardiac looping, which reveals their essential functions and shows that the NDR kinases are critically required during the early phase of organogenesis

  9. Rassf5 and Ndr1 or Ndr2 kinases regulate neuronal polarity through Par3 phosphorylation.

  10. NDRG1 promotes fetal growth and regulates the metabolic response to intrauterine hypoxic injury in a sexually dichotomous manner

  11. early growth response 1, a transcription factor that binds to the NDRG1 promoter, was mediated in the NDRG1 expression regulation by PKD2.

  12. Our findings do not support the proposed roles of NDRG1 in growth arrest, terminal differentiation, gene expression regulation and proteasomal degradation.

  13. may be a mast cell maturation-associated inducible protein that allows the cells to be susceptible to extracellular stimuli leading to degranulation

  14. Nickel induces HIF-1 transactivation and Cap43 protein expression through a PI-3K/Akt-dependent and p70(S6k)-independent pathway.

  15. results indicate that NDRG1 deficiency leads to Schwann cell dysfunction, suggesting that NDRG1 is essential for maintenance of the myelin sheaths in peripheral nerves

  16. NDRG1 may play an important role in the terminal differentiation of Schwann cells during nerve regeneration.

  17. Our data predict that the loss of NDRG1 leads to a Schwann cell autonomous phenotype resulting in demyelination, with secondary axonal loss.

  18. NDRG1 interacts with APO A-I and A-II and may have a role in the general mechanisms of HDL-mediated cholesterol transport

  19. Altered phenotypes of Ndrg1-deficient mast cells both in vivo and ex vivo suggest that NDRG1 has roles in the terminal maturation and effector function (degranulation) of mast cells.

  20. These expression patterns demonstrated the cell type-specific and ubiquitous localization of the NDRG family proteins. Each NDRG may play a partially redundant role in specific cells in the brain.

Zebrafish N-Myc Downstream Regulated 1 (NDRG1) interaction partners

  1. ndrg1b and fam49ab are 2 new modulators of PTEN signaling that control lymphoid differentiation in the zebrafish thymus.

Arabidopsis thaliana N-Myc Downstream Regulated 1 (NDRG1) interaction partners

  1. NDR1 plays a broad role both in mediating primary cellular functions in Arabidopsis through maintaining the integrity of the cell wall-plasma membrane connection and as a key signaling component of these responses during pathogen infection.

  2. SR1 plays an important role in plant immunity and ethylene signaling by directly regulating NDR1 and EIN3.

  3. The induction of defence responses and disease resistance to X. campestris pv. campestris strain 8004 requires NDR1 , RAR1 and SGT1b, suggesting that effector-triggered immunity plays a large role in resistance to this strain.

  4. Sequence analysis and mass spectrometry suggest that NDR1 is localized to the PM via a C-terminal glycosylphosphatidyl-inositol (GPI) anchor.

  5. demonstrate that the RIN4-NDR1 interaction occurs on the cytoplasmically localized N-terminal portion of NDR1 and that this interaction is required for the activation of resistance signaling following infection by P. syringae

  6. Mutations in NDR1 abolished the enhanced resistance of dnd mutants against Pseudomonas syringae pv. tomato and Hyaloperonospora parasitica but not Botrytis cinerea.

N-Myc Downstream Regulated 1 (NDRG1) profil antigène

Profil protéine

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with NDRG1

  • N-myc downstream regulated 1 (NDRG1) anticorps
  • N-myc downstream regulated gene 1 (Ndrg1) anticorps
  • N-myc downstream regulated 1 (Ndrg1) anticorps
  • N-myc downstream regulated 1 S homeolog (ndrg1.S) anticorps
  • N-myc downstream regulated 1 (ndrg1) anticorps
  • N-myc downstream regulated 1a (ndrg1a) anticorps
  • Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family (NDR1) anticorps
  • N-myc downstream regulated 1 L homeolog (ndrg1.L) anticorps
  • N-myc downstream regulated 1b (ndrg1b) anticorps
  • cap43 anticorps
  • cb775 anticorps
  • cmt4d anticorps
  • DRG-1 anticorps
  • drg1 anticorps
  • gc4 anticorps
  • hmsnl anticorps
  • ndr1 anticorps
  • NDRG1 anticorps
  • ndrg1-a anticorps
  • ndrg1-b anticorps
  • ndrg1l anticorps
  • ndrg4 anticorps
  • Ndrl anticorps
  • nmsl anticorps
  • non race-specific disease resistance 1 anticorps
  • proxy1 anticorps
  • rit42 anticorps
  • rtp anticorps
  • targ1 anticorps
  • tdd5 anticorps
  • wu:fb60h02 anticorps
  • xndrg1 anticorps
  • xNDRG1-A anticorps
  • zgc:63944 anticorps
  • zgc:73047 anticorps

Protein level used designations for NDRG1

N-myc downstream-regulated gene 1 protein , differentiation-related gene 1 protein , nickel-specific induction protein Cap43 , protein NDRG1 , protein regulated by oxygen-1 , reducing agents and tunicamycin-responsive protein , N-myc downstream regulated 1 , protein Ndr1 , N-myc downstream regulated gene 1 , protein NDRG1-B , xNDRG1-B , protein NDRG1-like , protein NDRG1-A , xNDRG1-A , N-myc downstream regulated gene 1, like , N-myc downstream regulated gene 1b , n-myc downstream-regulated gene 1b

10397 Homo sapiens
17988 Mus musculus
299923 Rattus norvegicus
380319 Xenopus laevis
420321 Gallus gallus
464411 Pan troglodytes
482049 Canis lupus familiaris
493508 Xenopus (Silurana) tropicalis
504499 Bos taurus
792085 Danio rerio
100068997 Equus caballus
100230327 Taeniopygia guttata
100401077 Callithrix jacchus
100466806 Ailuropoda melanoleuca
100596235 Nomascus leucogenys
697752 Macaca mulatta
821607 Arabidopsis thaliana
100728790 Cavia porcellus
447720 Xenopus laevis
393665 Danio rerio
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