NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 1, 7.5kDa Protéines (NDUFA1)

The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. De plus, nous expédions NDUFA1 Anticorps (81) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
NDUFA1 54405 O35683
Rat NDUFA1 NDUFA1 363441  
NDUFA1 4694 O15239
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Top NDUFA1 Protéines sur anticorps-enligne.fr

Showing 6 out of 7 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 to 55 Days
$7,493.38
Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
$5,262.31
Détails
Escherichia coli (E. coli) Humain GST tag NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 1, 7.5kDa (NDUFA1) (AA 1-70), (full length) protein (GST tag) 1 mg 60 to 71 Days
$1,842.50
Détails
Wheat germ Humain GST tag 10 μg 11 to 12 Days
$340.00
Détails
Levure Chinese Hamster His tag   1 mg 60 to 71 Days
$2,082.67
Détails
Levure Bonobo His tag   1 mg 60 to 71 Days
$2,082.67
Détails

NDUFA1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human , ,
,

Plus protéines pour NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 1, 7.5kDa (NDUFA1) partenaires d'interaction

Mouse (Murine) NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 1, 7.5kDa (NDUFA1) interaction partners

  1. In an X-chromosome linked model for partial Complex I deficiency, Ndufa1 mutant males displayed reduced respiratory exchange and produced less body heat.

  2. Species-specific and mutant MWFE proteins effect on the assembly of a functional mammalian mitochondrial complex I.

Human NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 1, 7.5kDa (NDUFA1) interaction partners

  1. Results from a study on gene expression variability markers in early-stage human embryos shows that NDUF1A is a putative expression variability marker for the 3-day, 8-cell embryo stage.

  2. The gene signature of OPA1, CTSA, NDUFA1, STK10 and PRDX1 was able to identify patients post-implant with a sensitivity of 91% and a specificity of 86% in discrimination between post-implant group and healthy controls.

  3. Fanconi anemia complementation group A mutants show defective respiration through Complex I, diminished ATP production and metabolic sufferance with an increased AMP/ATP ratio.

  4. Heterozygous mutation in the X chromosomal NDUFA1 gene in a girl with complex I deficiency

  5. Mutations in the NDUFA1 gene is linked to a delayed mitochondrial network recovery in OXPHOS disorders.

  6. Species-specific and mutant MWFE proteins effect on the assembly of a functional mammalian mitochondrial complex I.

  7. A family-based association study finds that the NDUFA1 gene is unlikely to harbor a major visual loss susceptibility locus for Leber hereditary optic neuropathy.

  8. Oxidative stress and partial deficiencies of mitochondrial complex I are key factors in the pathogenesis of Parkinson's disease. (REVIEW)

  9. Suppression of NDUFA1 expression could represent a key pathogenic mechanism in the development of basal cell carcinoma

  10. Two novel p.Gly8Arg and p.Arg37Ser hemizygous mutations in NDUFA1 were identified in two unrelated male patients presenting with Leigh's syndrome and with myoclonic epilepsy and developmental delay.

  11. hypothesize that the novel G32R mutation in NDUFA1 is causing complex I deficiency either by itself or in synergy with additional mtDNA variants

Cow (Bovine) NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 1, 7.5kDa (NDUFA1) interaction partners

  1. subunit MWFE is required for assembly into complex I of seven hydrophobic subunits encoded in the mitochondrial genome

Profil protéine NDUFA1

Profil protéine

The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the 'hydrophobic protein' (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function.

Gene names and symbols associated with NDUFA1

  • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 (Ndufa1)
  • NADH:ubiquinone oxidoreductase subunit A1 (Ndufa1)
  • NADH:ubiquinone oxidoreductase subunit A1 (NDUFA1)
  • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa (NDUFA1)
  • 1810049F12Rik Protéine
  • CI-MWFE Protéine
  • MWFE Protéine
  • RGD1560955 Protéine
  • ZNF183 Protéine

Protein level used designations for NDUFA1

CI-MWFE , NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 (7.5kD, MWFE) , NADH dehydrogenase 1 alpha subcomplex, 1 , NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 , NADH ubiquinone oxidoreductase subunit MWFE , NADH-ubiquinone oxidoreductase MWFE subunit , complex I-MWFE , Complex I-MWFE , NADH ubiquinone oxidoreductase NDUFA1 , NADH oxidoreductase subunit MWFE , NADH:ubiquinone oxidoreductase (complex 1) , complex I MWFE subunit , type I dehydrogenase

GENE ID SPECIES
54405 Mus musculus
363441 Rattus norvegicus
100689328 Cricetulus griseus
4694 Homo sapiens
481033 Canis lupus familiaris
327673 Bos taurus
100983914 Pan paniscus
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