NEL-Like 1 (Chicken) Protéines (NELL1)

NELL1 encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. De plus, nous expédions NEL-Like 1 (Chicken) Anticorps (39) et NEL-Like 1 (Chicken) Kits (10) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
NELL1 338352 Q2VWQ2
NELL1 4745 Q92832
NELL1 81733 Q62919
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
Human Cells Humain His tag   10 μg Connectez-vous pour afficher 15 to 16 Days
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
HEK-293 Cells Humain His tag   10 μg Connectez-vous pour afficher 4 to 8 Days

NELL1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human , , ,
Rat (Rattus)

Plus protéines pour NEL-Like 1 (Chicken) (NELL1) partenaires d'interaction

Mouse (Murine) NEL-Like 1 (Chicken) (NELL1) interaction partners

  1. Nell-1-haploinsufficient mice have normal skeletal development but undergo age-related osteoporosis, characterized by a reduction in osteoblast:osteoclast ratio and increased bone fragility.

  2. NELL-1570 has the potential to be used for cell-based or hormone-based therapy of bone regeneration.

  3. These results suggest that an oligomerization-induced conformational change in the C-terminal region of NELL1 is important for the efficient mediation of cell adhesion and spreading by NELL1.

  4. Nell-1 might play a role in ameloblast and odontoblast differentiation, secretion and mineralization of the extracellular enamel matrix, molar crown morphogenesis, as well as root formation during the entire development period.

  5. NELL-1 protein promotes cell adhesion in ST2 cells.

  6. The C-terminal region of NELL1 mediates osteoblastic cell adhesion through integrin alpha3beta1

  7. data suggest Nell-1 is important growth factor for regulation of osteochondral differentiation regulating both Runx2 and Sox9 expression in calvarium. Nell-1 is required for normal craniofacial membranous and endochondral skeletal development.

  8. These studies suggest that Nell-1 is a potent anti-adipogenic agent. Moreover, Nell-1 signaling may inhibit adipogenic differentiation via a Hedgehog dependent mechanism.

  9. Nfatc2 likely plays an important role in Nell-1-mediated osteochondral differentiation in vitro and in vivo.

  10. Nell-1 supports continued osteoblastic differentiation and function in osteoblastic lineage cells during calvarial development. Nell-1 is a key functional, downstream mediator of Runx2 osteogenic activity.

  11. A recessive, neonatal-lethal point mutation in the Nell1 gene causes cranial and skeletal defects.

  12. Nell-1 reduced osterix-producing cells and increased bone sialoprotein, osteocalcin, and BMP-7 expression.

Human NEL-Like 1 (Chicken) (NELL1) interaction partners

  1. Study results suggest that NELL1 induces lung cancer stemlike cell differentiation, which provides a new potential therapeutic target for cancer stem cells.

  2. Results show that NELL1 methylation level was 6.8% higher in renal cell cancer (RCC) tissues associated with advanced disease of distant metastases, and shorter RFS. Analyses suggested that NELL1 DNA methylation is a promising candidate prognostic epigenetic biomarker for more detailed analyses of RCC disease.

  3. This work indicates that NELL-1, HMGB1, and CCN2 might enhance bone defect healing via the recruitment of endogenous cells and induction of vascularization and act via different processes than BMP2.

  4. NELL1 variant is associated with tobacco- and HPV-mediated oral oncogenesis.

  5. Results demonstrate that NELL1 is differentially expressed in fusion-positive alveolar rhabdomyosarcoma (ARMS) and in embryonal rhabdomyosarcoma (ERMS) samples, and they show that this transcriptional difference partially depends on genomic DNA methylation. The study also found that high NELL1 levels are correlated with negative RMS prognostic factors and with poor tumor outcomes.

  6. lipoaspirate-derived hPSCs present a novel and abundant cell source of MSCs for cartilage regeneration, and the combinatorial application of NELL-1, TGF-beta3, and BMP-6 with hPSCs may remarkably enhance and accelerate cartilage repair.

  7. establish the feasibility of combining NELL-1 with BMP2 to improve clinical bone regeneration and provide mechanistic insight into canonical Wnt pathway activity during NELL-1 and BMP2 osteogenesis

  8. Data suggest that TSPN (N-terminal thrombospondin-1-like) domain of NELL1 exhibits major heparin-binding sites which may be involved in interaction of NELL1 with cell surface heparan sulfate proteoglycans.

  9. NELL-1 signaling activates Wnt/beta-catenin signaling.

  10. We also detected lower relative expression of Nell-1 by real-time PCR. Furthermore, immunohistochemical analyses revealed that Nell-1 staining was less intense in cancer tissue relative to normal tissue and that the tumor cells had spread to the muscle

  11. CpG islands in the NELL1 and NELL2 promoters are hypermethylated in renal cell carcinoma.NELL1 and NELL2 protein expression is downregulated in clear cell renal carcinoma.

  12. NELL-1 demonstrates diffuse and reliable expression in benign but not malignant bone-forming skeletal tumors

  13. NELL1 overexpression greatly enhanced the osteogenic differentiation and mineral synthesis of iPSC-MSCs on RGD-grafted CPC scaffold for the first time.

  14. Two single-nucleotide polymorphisms of the NELL1 gene may represent a novel mechanism underlying hydrochlorothiazide-induced adverse metabolic effects (meta-analysis).

  15. NELL1 is able to promote the osteogenic differentiation of periodontal ligament stem cells, which may be related to the downregulation of Msx2 expression.

  16. Activation of the JNK pathway is necessary to mediate terminal osteogenic different-iation of Saos-2 osteosarcoma cells by rhNELL-1.

  17. Data indicate that LvNELL1 infection promoted the osteogenic differentiation of hADSCs, and the effect was comparable with that of LvBMP2.

  18. SHH and NELL-1 directed signaling produced additive effects on the pro-osteogenic and antiadipogenic differentiation of adipose derived stem cells.

  19. Prediction of radiographic severity in Ankolysing Spondylitis based on clinical variables can be significantly improved by including SNPs at ADRB1 (rs1801253), NELL1 (rs8176785) and MHC (rs1634747, rs9270986, rs7451962 and rs241453) genes.

  20. These results identify one potential mechanism of action for rhNELL-1 induced osteogenesis and highlight a fundamental difference between NELL-1 and BMP-2 signaling.

Profil protéine NEL-Like 1 (Chicken) (NELL1)

Profil protéine

This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NEL-Like 1 (Chicken) Protéines (NELL1)

  • NEL-like 1 (Nell1)
  • neural EGFL like 1 (NELL1)
  • neural EGFL like 1 (Nell1)
  • B230343H07Rik Protéine
  • IDH3GL Protéine
  • l7R6 Protéine
  • NRP1 Protéine

Protein level used designations for NEL-Like 1 (Chicken) Protéines (NELL1)

NEL-like protein 1 , protein kinase C-binding protein NELL1 , NELL-1 protein short isoform , nel-related protein 1 , neural epidermal growth factor-like 1

338352 Mus musculus
4745 Homo sapiens
81733 Rattus norvegicus
100336918 Bos taurus
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