NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) Protéines (NAB2)

NAB2 encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. De plus, nous expédions NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) Anticorps (109) et NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) Kits (4) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
NAB2 17937 Q61127
Rat NAB2 NAB2 314910  
NAB2 4665 Q15742
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Top NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) Protéines sur anticorps-enligne.fr

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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,626.73
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Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,626.73
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Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$340.00
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HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
$888.80
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NAB2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human , ,
, ,

Plus protéines pour NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) (NAB2) partenaires d'interaction

Mouse (Murine) NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) (NAB2) interaction partners

  1. These findings indicate a requirement for Nab2 in maintaining thymocyte number in male mice with age and in response to stress.

  2. Data suggest that histone deacetylase inhibitors inhibit the induction of NGF1A-binding protein Nab2 by brain derived neurotrophic factor (BDNF), and thereby the relative induction of dopamine and cyclic AMP-regulated phosphoprotein, 32 kDa (DARPP-32).

  3. Nab2 is a novel endogenous negative regulator of Egr-1-dependent TGF-beta signaling responsible for setting the intensity of fibrotic responses

  4. Nab1 and Nab2 proteins are necessary for Schwann cells to exit the cell cycle, downregulate suppressed cAMP-inducible protein (SCIP) expression and upregulate expression of critical myelination genes.

  5. repression of the endogenous Rad gene by NAB2 involves interaction with the CHD4 (chromodomain helicase DNA-binding protein 4) subunit of the NuRD (nucleosome remodeling and deacetylase) chromatin remodeling complex

  6. NAB2 enhances IL-2 transcription by acting as a coactivator for Egr-1.NAB2 is recruited to the Egr-1 binding site of the IL-2 promoter.

  7. We report here, that FGF23 induces not only Egr-1 but also two isoforms of NAB2, which are specific co-repressors of Egr-1.

  8. Helps control the fate of antigen recognition in T cells.

Human NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) (NAB2) interaction partners

  1. Here, we demonstrate that pulmonary adenofibromas are neoplastic lesions harbouring NAB2-STAT6 fusion genes ,the molecular hallmark of solitary fibrous tumours.

  2. Our results represented that meningeal solitary fibrous tumor/hemangiopericytoma were in a single biological spectrum with NAB2-STAT6 gene fusion as was nonmeningeal solitary fibrous tumor

  3. The detection of nuclear relocation of STAT6 with immunohistochemistry is a characteristic of solitary fibrous tumours (SFTs), and may serve as a diagnostic marker that indicates NAB2-STAT6 fusion and helps to discriminate SFTs from histological mimics.

  4. Variants of the NAB2-STAT6 fusion gene are found in solitary fibrous tumors of the meninges.

  5. NAB2-STAT6 fusion is a diagnostic tumor marker for papillary' solitary fibrous tumor/hemangiopericytoma of brain.

  6. the majority of intrathoracic SFTs exhibited STAT6 nuclear staining, and NAB2ex4-STAT6ex2/3 was the predominant fusion type.

  7. Case Report: NAB2-STAT6 fusion in glioblastoma.

  8. We delineate the common and rare NAB2-STAT6 fusion variants in solitary fibrous tumors

  9. This study confirms that meningeal Meningeal solitary fibrous tumor and hemangiopericytoma represent a histopathologic continuum linked by STAT6 nuclear expression and NAB2-STAT6 fusion similar to their soft tissue counterparts.

  10. It is associated with local recurrence and late distance metastasis of brain tumors to extracranial sites.

  11. This study validated the existence of the NAB2-STAT6 fusion gene in solitary fibrous tumors and examined its relation with pathological features.

  12. also identified NAB2-STAT6 fusions in two hemangiopericytomas diagnosed in the past with a common variant of NAB2ex6-STAT6ex16/17

  13. There was no association between solitary fibrous tumors with either NAB2 exon 4-STAT6 exon 2 or 3 fusion and tumors with other fusions regarding the frequency of mutations in the examined genes (P = .201).

  14. reverse transcriptase PCR analysis identified a nerve growth factor inducible-A binding protein 2-STAT6 gene fusion. Our case supports the utility of STAT6 immunohistochemistry as an adjunct in the diagnosis of soft-tissue SFT with loss of CD34 positivity

  15. Tumors with the most common fusion variant, NAB2ex4-STAT6ex2/3, corresponded to classic pleuropulmonary solitary fibrous tumors with diffuse fibrosis and mostly benign behavior and occurred in older patients

  16. 44 SFTs were studied to identify pathogenetically important genetic rearrangements. RT-PCR analysis identified a NAB2/STAT6 fusion in 37/41 cases.

  17. Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion

  18. NAB2 and EGR-1 exert opposite roles in regulating TRAIL expression in human Natural Killer cells.

  19. A gene fusion of the transcriptional repressor NAB2 with the transcriptional activator STAT6 is the defining driver mutation of solitary fibrous tumor.

  20. A NAB2-STAT6 fusion is a distinct molecular feature of solitary fibrous tumors.

Profil protéine NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) (NAB2)

Profil protéine

This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Gene names and symbols associated with NAB2

  • NGFI-A binding protein 2 (EGR1 binding protein 2) (nab2)
  • Ngfi-A binding protein 2 (Nab2)
  • NGFI-A binding protein 2 (NAB2)
  • AI451907 Protéine
  • MADER Protéine

Protein level used designations for NAB2

NGFI-A binding protein 2 (EGR1 binding protein 2) , EGR-1-binding protein 2 , NGFI-A binding protein 2 (EGR-1 binding protein 2) , NGFI-A-binding protein 2 , EGR1 binding protein 2 , melanoma-associated delayed early response protein

GENE ID SPECIES
100145178 Xenopus (Silurana) tropicalis
17937 Mus musculus
314910 Rattus norvegicus
4665 Homo sapiens
504755 Bos taurus
481122 Canis lupus familiaris
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