NIMA (Never in Mitosis Gene A)-Related Kinase 6 Protéines (NEK6)

The protein encoded by NEK6 is a kinase required for progression through the metaphase portion of mitosis. De plus, nous expédions NEK6 Anticorps (80) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
NEK6 59126 Q9ES70
NEK6 10783 Q9HC98
NEK6 360161 P59895
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Top NEK6 Protéines sur anticorps-enligne.fr

Showing 10 out of 15 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Baculovirus infected Insect Cells Humain Inconjugué 5 μg 2 to 3 Days
$295.00
Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Détails
Wheat germ Humain GST tag 10 μg 11 to 12 Days
$414.29
Détails
Wheat germ Humain GST tag 10 μg 11 to 12 Days
$414.29
Détails
Cellules d'insectes Humain His-GST 100 μg 11 to 12 Days
$1,502.67
Détails
Levure Sanglier His tag   1 mg 60 to 71 Days
$2,836.17
Détails
Levure Rat His tag   1 mg 60 to 71 Days
$2,836.17
Détails
Levure Arabidopsis thaliana His tag   1 mg 60 to 71 Days
$3,157.00
Détails

NEK6 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human , , , ,
, , ,
Rat (Rattus)

Plus protéines pour NIMA (Never in Mitosis Gene A)-Related Kinase 6 (NEK6) partenaires d'interaction

Mouse (Murine) NIMA (Never in Mitosis Gene A)-Related Kinase 6 (NEK6) interaction partners

  1. NEK6 is overexpressed in various human cancer tissues, and ectopic expression of NEK6 increases tumor promoter-induced transformation of JB6 Cl41 mouse epidermal cells.

  2. During early embryogenesis nek6 is highly expressed in primary giant trophoblast cells. Later in embryogenesis, nek6 is found in ventricular and sub-ventricular regions.

Arabidopsis thaliana NIMA (Never in Mitosis Gene A)-Related Kinase 6 (NEK6) interaction partners

  1. NEK6 forms heterodimers with NEK4 and NEK5 to regulate cortical microtubule organization possibly through the phosphorylation of beta-tubulins.

Human NIMA (Never in Mitosis Gene A)-Related Kinase 6 (NEK6) interaction partners

  1. our results imply that Nek6 plays a facilitating role in breast cancer cell proliferation

  2. cis-regulatory circuits that lead to overexpression of NEK6, a mitosis-associated kinase, in human B cell lymphoma, were analyzed.

  3. High NEK6 expression is associated with Cluster Amplified Centrosomes in cancer.

  4. Signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14 to properly coordinate cytokinesis.

  5. our studies establish NEK6 signaling as a central mechanism mediating castration-resistant prostate cancer

  6. overexpression of PAK1, NEK6, AURKA, and AURKB genes in patients with Colorectal adenomatous polyp and colorectal cancer in the Turkish population.

  7. We found that NEK6-mediated phosphorylation of TPP1 Ser255 in G2/M phase regulates the association between telomerase activity and TPP1. Furthermore, we found evidence that POT1 negatively regulates TPP1 phosphorylation because the level of Ser255 phosphorylation was elevated when telomeres were elongated by a POT1 mutant lacking its OB-fold domains

  8. Overexpression of AURKA and NEK6 genes was significantly more pronounced in Ulcerative colitis patients with more extensive colon involvement

  9. NEK6 suppresses the cell growth arrest induced by TGFbeta. Mechanically, NEK6 blocks nuclear translocation of Smad4, which is essential for TGFbeta function.

  10. Nek6 is also a critical signaling molecule that helps prevent cardiac hypertrophy and inhibits the Akt signaling pathway.

  11. Nek6 facilitates association of Hsp72 with the mitotic spindle, where it promotes stable K-fiber assembly through recruitment of the ch-TOG-TACC3 complex.

  12. Nek6 plays an important role in the premature senescence of cancer cells.

  13. High Nek6 is associated with hepatic cell cancer.

  14. Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5.

  15. the first low resolution 3D structure of hNek6 protein in solution

  16. These results suggest that the increased expression of Nek6 renders cancer cells resistant to premature senescence, and targeting Nek6 could be an efficient strategy for cancer treatment.

  17. DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9.

  18. Findings open new perspectives in the study of hNek6 role in cancer by analyzing its novel interactions in specific pathways in tumor cells, which may provide important implications for drug design and cancer therapy.

  19. NEK6 expression is downregulated in both replicative and premature senscence of human cnacer cells, and the inhibition of Nek6 activity is important for the onset of cellular senescence.

  20. NEK6 is overexpressed in various human cancer tissues, and ectopic expression of NEK6 increases tumor promoter-induced transformation of JB6 Cl41 mouse epidermal cells.

Profil protéine NEK6

Profil protéine

The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene.

Gene names and symbols associated with NEK6

  • NIMA (never in mitosis gene a)-related expressed kinase 6 (Nek6)
  • NIMA-related kinase 6 (nek6)
  • NIMA related kinase 6 (NEK6)
  • Serine/Threonine kinase catalytic domain protein (NEK5)
  • NIMA-related kinase 6 S homeolog (nek6.S)
  • NIMA-related kinase 6 (Nek6)
  • 1300007C09Rik Protéine
  • ATNEK5 Protéine
  • MOE17.17 Protéine
  • NIMA-RELATED KINASE5 Protéine
  • NIMA-related kinase 5 Protéine
  • si:ch211-167p9.4 Protéine
  • SID6-1512 Protéine

Protein level used designations for NEK6

NIMA-related expressed kinase 6 , never in mitosis A-related kinase 6 , nimA-related protein kinase 6 , serine/threonine-protein kinase Nek6 , putative serine-threonine protein kinase , NIMA (never in mitosis gene a)-related kinase 6 , protein kinase SID6-1512 , NIMA (never in mitosis gene a)-related expressed kinase 6

GENE ID SPECIES
59126 Mus musculus
497165 Danio rerio
417101 Gallus gallus
609003 Canis lupus familiaris
100514624 Sus scrofa
515816 Bos taurus
821634 Arabidopsis thaliana
10783 Homo sapiens
380346 Xenopus laevis
360161 Rattus norvegicus
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