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NSUN2 encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors.
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Human Polyclonal NSUN2 Primary Antibody pour ICC, IF - ABIN4340777
Horn, Kim, Wright, Wong, Stewart, Burke, Roux: A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton. dans The Journal of cell biology 2013
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Cow (Bovine) Polyclonal NSUN2 Primary Antibody pour WB - ABIN2783512
Sakita-Suto, Kanda, Suzuki, Sato, Takata, Tatsuka: Aurora-B regulates RNA methyltransferase NSUN2. dans Molecular biology of the cell 2007
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study identified NSun2 as a novel component of the chromatoid body and show that NSun2 is essential for germ cell differentiation in the testis
Steady-state levels of unmethylated tRNAs were substantially reduced, and loss of Dnmt2 (Montrer TRDMT1 Anticorps) and NSun2 was further associated with reduced rates of overall protein synthesis.
NSUN2 localizes to the nucleolus of Purkinje cells in the cerebellum. Mutation to arginine at residue 679 causes NSUN2 to fail to localize within the nucleolus.
we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin
Misu is a novel downstream Myc (Montrer MYC Anticorps) target that methylates RNA polymerase III transcripts. Misu mediates Myc (Montrer MYC Anticorps)-induced cell proliferation and growth and is a potential target for cancer therapies.
These results suggest a novel mechanism by which c-Myc promotes proliferation by stabilizing the mitotic spindle in fast-dividing cells via Misu and NuSAP.
Patients with high NSUN2 levels had approximately 22 months shorter overall survival, and had a higher mortality risk than those with low one (p-trend = 0.020).
Dysregulation of ALYREF (Montrer THOC4 Anticorps)-mediated mRNA export upon NSUN2 depletion could be restored by reconstitution of wild-type but not methyltransferase-defective NSUN2.
methylation at m6A (Montrer GPM6A Anticorps) by METTL3 (Montrer METTL3 Anticorps)/METTL14 (Montrer METTL14 Anticorps) facilitates the methylation of m5C by NSUN2, and vice versa. NSUN2-mediated m5C and METTL3 (Montrer METTL3 Anticorps)/METTL14 (Montrer METTL14 Anticorps)-mediated m6A (Montrer GPM6A Anticorps) methylation synergistically enhance p21 (Montrer CDKN1A Anticorps) expression at the translational level
Findings indicate the critical impact of RNA methyltransferase NSUN2-mediated mRNA methylation in promoting premature senescence.
Our findings provide a unique insight into the roles and effects of NSUN2 overexpression in breast cancer cells
findings point to YB-1 (Montrer YBX1 Anticorps) and NSUN2 as possible mediators of the process of transfer of specific mRNAs into exosomes, allowing us to speculate on an involvement of these proteins in the mRNA sorting via the recognition of the above motifs
These findings indicate that NSun2-mediated mRNA methylation regulates p27 (Montrer PAK2 Anticorps) and CDK1 (Montrer CDK1 Anticorps) levels during replicative senescence.
A novel homozygous variant c.1020delA in NSUN2 gene segregated in an autosomal recessive mode in the family of a child with intellectual disability. It causes a frameshift and premature stop codon, decreasing mRNA levels.
By methylating the CDK1 (Montrer CDK1 Anticorps) mRNA at the 3'UTR (Montrer UTS2R Anticorps), NSun2 enhances the translation of CDK1 (Montrer CDK1 Anticorps), thereby influencing entry into and the progression of the cell division cycle.
tRNA modifying enzymes, NSUN2 and METTL1 (Montrer METTL1 Anticorps), determine sensitivity to 5-fluorouracil in HeLa cells
This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Myc-induced SUN domain containing protein
, NOL1/NOP2/Sun domain family 2
, myc-induced SUN domain-containing protein
, tRNA (cytosine(34)-C(5))-methyltransferase
, tRNA (cytosine-5-)-methyltransferase NSUN2
, NOL1/NOP2/Sun domain family, member 2
, NOP2/Sun domain family, member 2
, 5-methycytoisine methyltransferase
, Myc-induced SUN-domain-containing protein
, NOL1/NOP2/Sun domain family member 2
, substrate of AIM1/Aurora kinase B
, tRNA methyltransferase 4 homolog