anti-NOP2/Sun Domain Family, Member 2 (NSUN2) Anticorps

NSUN2 encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. De plus, nous expédions NSUN2 Protéines (3) et et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
NSUN2 28114 Q1HFZ0
NSUN2 54888 Q08J23
NSUN2 361191  
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Top anti-NSUN2 Anticorps sur anticorps-enligne.fr

Showing 10 out of 48 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-NSUN2 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Hela cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$319.00
Détails
Humain Lapin Inconjugué WB NSUN2 Antibody (Center) (ABIN654767) western blot analysis in mouse spleen tissue lysates (35 µg/lane). This demonstrates the NSUN2 antibody detected the NSUN2 protein (arrow). All lanes : Anti-NSUN2 Antibody (Center) at 1:1000 dilution Lane 1: Hela whole cell lysate Lane 2: Jurkat whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 86 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:1000 400 μL Connectez-vous pour afficher 10 to 11 Days
$385.00
Détails
Humain Lapin Inconjugué EIA, WB NSUN2 Antibody (Center) western blot analysis in mouse spleen tissue lysates (35µg/lane).This demonstrates the NSUN2 antibody detected the NSUN2 protein (arrow). 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$484.00
Détails
Boeuf (Vache) Lapin Inconjugué WB Host:  Rabbit  Target Name:  NSUN2  Sample Type:  PANC1 Whole Cell lysates  Antibody Dilution:  1.0ug/ml 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p) Immunohistochemistry-Paraffin: NSUN2 Antibody [NBP1-82189] - Staining of human testis shows strong nuclear positivity in cells in seminiferus ducts and leydig cells. Immunocytochemistry/Immunofluorescence: NSUN2 Antibody [NBP1-82189] Staining of human cell line A-431 shows positivity in nucleus. 0.1 mL Connectez-vous pour afficher 10 to 13 Days
$494.38
Détails
Humain Lapin Inconjugué IHC, WB Western blot analysis of extracts from various samples, using NSUN2 antibody. Lane 1: 293 treated with blocking peptide. Lane 2: 293; Lane 3: hela; ABIN6272947 at 1/100 staining Rat brain tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Connectez-vous pour afficher 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué WB Western Blot at 1:1000 dilution Lane 1: Hela whole cell lysate Lane 2: Jurkat whole cell lysate Lysates/proteins at 20 ug per lane. Western blot analysis in mouse spleen tissue lysates (35ug/lane). 400 μL Connectez-vous pour afficher 2 to 3 Days
$515.63
Détails
Humain Lapin Inconjugué IF, IHC, WB Western blot analysis of extracts of various cell lines, using NSUN2 antibody (ABIN1873963) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s. 100 μL Connectez-vous pour afficher 16 Days
$366.77
Détails
Humain Lapin Inconjugué ELISA, WB 50 μg Connectez-vous pour afficher 2 to 3 Days
$446.88
Détails

anti-NSUN2 Anticorps mieux référencés

  1. Cow (Bovine) Polyclonal NSUN2 Primary Antibody pour WB - ABIN2783512 : Sakita-Suto, Kanda, Suzuki, Sato, Takata, Tatsuka: Aurora-B regulates RNA methyltransferase NSUN2. dans Molecular biology of the cell 2007 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre NSUN2 partenaires d’interaction

Mouse (Murine) NOP2/Sun Domain Family, Member 2 (NSUN2) interaction partners

  1. study identified NSun2 as a novel component of the chromatoid body and show that NSun2 is essential for germ cell differentiation in the testis

  2. Steady-state levels of unmethylated tRNAs were substantially reduced, and loss of Dnmt2 and NSun2 was further associated with reduced rates of overall protein synthesis.

  3. NSUN2 localizes to the nucleolus of Purkinje cells in the cerebellum. Mutation to arginine at residue 679 causes NSUN2 to fail to localize within the nucleolus.

  4. we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin

  5. Misu is a novel downstream Myc target that methylates RNA polymerase III transcripts. Misu mediates Myc-induced cell proliferation and growth and is a potential target for cancer therapies.

  6. These results suggest a novel mechanism by which c-Myc promotes proliferation by stabilizing the mitotic spindle in fast-dividing cells via Misu and NuSAP.

Human NOP2/Sun Domain Family, Member 2 (NSUN2) interaction partners

  1. Upregulation of NSUN2 expression is associated with ovarian cancer.

  2. Patients with high NSUN2 levels had approximately 22 months shorter overall survival, and had a higher mortality risk than those with low one (p-trend = 0.020).

  3. Dysregulation of ALYREF-mediated mRNA export upon NSUN2 depletion could be restored by reconstitution of wild-type but not methyltransferase-defective NSUN2.

  4. methylation at m6A by METTL3/METTL14 facilitates the methylation of m5C by NSUN2, and vice versa. NSUN2-mediated m5C and METTL3/METTL14-mediated m6A methylation synergistically enhance p21 expression at the translational level

  5. Findings indicate the critical impact of RNA methyltransferase NSUN2-mediated mRNA methylation in promoting premature senescence.

  6. Our findings provide a unique insight into the roles and effects of NSUN2 overexpression in breast cancer cells

  7. findings point to YB-1 and NSUN2 as possible mediators of the process of transfer of specific mRNAs into exosomes, allowing us to speculate on an involvement of these proteins in the mRNA sorting via the recognition of the above motifs

  8. These findings indicate that NSun2-mediated mRNA methylation regulates p27 and CDK1 levels during replicative senescence.

  9. A novel homozygous variant c.1020delA in NSUN2 gene segregated in an autosomal recessive mode in the family of a child with intellectual disability. It causes a frameshift and premature stop codon, decreasing mRNA levels.

  10. By methylating the CDK1 mRNA at the 3'UTR, NSun2 enhances the translation of CDK1, thereby influencing entry into and the progression of the cell division cycle.

  11. tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells

  12. Report frequencies of short tandem repeat markers linked to TUSC3 (MRT7) or NSUN2 (MRT5) genes used for homozygosity mapping of recessive intellectual disability.

  13. Results show that NSun2 methylates primary (pri-miR-125b), precursor (pre-miR-125b), and mature microRNA 125b (miR-125b) in vitro and in vivo.

  14. In conclusion, failure in NSun2-mediated tRNA methylation contributes to human diseases via stress-induced RNA cleavage.

  15. Impaired processing of vault ncRNA may contribute to the etiology of NSun2-deficiency human disorders.

  16. Enrolled a multiplex consanguineous family from the United Arab Emirates with many key clinical features of Dubowitz syndrome. Identified a homozygous splice mutation in the NSUN2 gene, encoding a conserved RNA methyltransferase.

  17. findings show that NSun2, a transfer RNA methyltransferase, inhibits the turnover of p16(INK4) mRNA; conclude that NSun2-mediated methylation of the p16 3'UTR is a novel mechanism to stabilize p16 mRNA

  18. Increased gene copy number and high protein expression of NSUN2 is associated with cancers.

  19. A deficiency in NSUN2 function causes intellectual disability in individuals homozygous for these mutations.

  20. The substitution of glycine to arginine at position 679 impairs the proper cellular localization of NSUN2 to the nucleolus. This mutation causes autosomal-recessive intellectual disability.

NSUN2 profil antigène

Profil protéine

This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene names and symbols associated with NSUN2

  • NOL1/NOP2/Sun domain family member 2 (Nsun2) anticorps
  • NOP2/Sun RNA methyltransferase family member 2 (NSUN2) anticorps
  • NOP2/Sun RNA methyltransferase family, member 2 (Nsun2) anticorps
  • NOP2/Sun RNA methyltransferase family member 2 S homeolog (nsun2.S) anticorps
  • D13Wsu123e anticorps
  • MISU anticorps
  • MRT5 anticorps
  • RGD1311954 anticorps
  • SAKI anticorps
  • TRM4 anticorps

Protein level used designations for NSUN2

Myc-induced SUN domain containing protein , NOL1/NOP2/Sun domain family 2 , myc-induced SUN domain-containing protein , tRNA (cytosine(34)-C(5))-methyltransferase , tRNA (cytosine-5-)-methyltransferase NSUN2 , NOL1/NOP2/Sun domain family, member 2 , NOP2/Sun domain family, member 2 , 5-methycytoisine methyltransferase , Myc-induced SUN-domain-containing protein , NOL1/NOP2/Sun domain family member 2 , hTrm4 , substrate of AIM1/Aurora kinase B , tRNA methyltransferase 4 homolog

GENE ID SPECIES
28114 Mus musculus
420938 Gallus gallus
54888 Homo sapiens
516044 Bos taurus
361191 Rattus norvegicus
414460 Xenopus laevis
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