NUAK Family, SNF1-Like Kinase, 2 Protéines (NUAK2)

Stress-activated kinase involved in tolerance to glucose starvation. De plus, nous expédions NUAK Family, SNF1-Like Kinase, 2 Anticorps (81) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
NUAK2 81788 Q9H093
NUAK2 74137 Q8BZN4
Rat NUAK2 NUAK2 289419 Q66HE5
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Showing 5 out of 8 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Détails
Wheat germ Humain GST tag 2 μg 11 to 12 Days
$338.33
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Cellules d'insectes Humain His-GST 100 μg 11 to 12 Days
$1,502.67
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Cellules d'insectes Humain GST tag   10 μg 3 to 4 Days
$310.00
Détails

NUAK2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
, ,
Mouse (Murine)

Plus protéines pour NUAK Family, SNF1-Like Kinase, 2 (NUAK2) partenaires d'interaction

Human NUAK Family, SNF1-Like Kinase, 2 (NUAK2) interaction partners

  1. Data (including data from studies in knockout and transgenic mice) suggest that NUAK2/SNARK is involved in both adipose inflammation and energy metabolism in adipocytes; additionally, genome-wide association studies suggest that 2 SNPs in NUAK2/SNARK (rs4682880, rs4682676) are associated with obesity in women.

  2. miR143 inhibited the proliferation, migration and invasion of the glioblastoma cells by degrading NUAK2 in glioblastoma.

  3. Sucrose non-fermenting AMPK related kinase/Pentraxin 3 combined role in immunometabolic signaling and DNA damage response is proposed to accelerate cardiovascular complications in systemic lupus erythematosus patients

  4. NUAK2 silencing and inactivation of the PI3K pathway efficiently controlled CDK2 expression, whereas CDK2 inactivation specifically abrogated the growth of NUAK2-amplified and PTEN-deficient melanoma cells.

  5. The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-beta signaling.

  6. Activation of AMP-activated protein kinase protects the integrity of the blood-brain barrier by suppressing the induction of NADPH oxidase-derived superoxide anions.

  7. Considers possible roles of NUAK2 in tumorigenesis in general and suggest that NUAK2 has pivotal roles in acral melanomagenesis.

  8. MLCP (myosin light chain phosphatase) activation is counteracted by a previously unrecognized association between MRIP (myosin phosphatase Rho-interacting protein) and the inducible kinase NUAK2

  9. This study further supports the importance of NUAK2 in cancer development and tumor progression, while AMPK has antioncogenic properties.

  10. Data show that SNARK is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle.

  11. SNARK is an NF-kappaB-regulated anti-apoptotic gene that contributes to the tumor-promoting activity of CD95 in apoptosis-resistant tumor cells

  12. These data suggests different phosphorylation and regulation of MYPT1 activity by NUAK2.

  13. EBV LMP1 upregulated the expression of SNARK; SNARK expression increased drug resistance in response to doxorubicin increased of cancer cell survival

  14. The nuclear localizing SNARK altered transcriptome profiles and a considerable part of these alterations were canceled by the mutation of NLS, suggesting the ability of SNARK to modulate gene expression dependent on its nuclear localization.

  15. Skeletal muscle SNARK expression is increased in human obesity, and in response to metabolic stressors, but not type 2 diabetes. Partial SNARK depletion failed to modify either glucose or lipid metabolism.

  16. This study describes the cloning and characterization of the rat SNARK homolog, mapping of the human SNARK gene to 1q32, and a potential functional role as mediator of the cellular response to metabolic stress.

Mouse (Murine) NUAK Family, SNF1-Like Kinase, 2 (NUAK2) interaction partners

  1. Using liver cancer as a model, NUAK2 was identified as an essential mediator of YAP-driven hepatomegaly and tumorigenesis in vivo.

  2. Data (including data from studies in knockout and transgenic mice) suggest that Nuak2/Snark is involved in both adipose inflammation and energy metabolism in white/brown adipocytes; Nuak2/Snark appears to regulate thermogenesis in brown adipocytes.

  3. These findings reveal a critical role for SNARK in myocyte survival and the maintenance of muscle mass with age.

  4. NUAK1 and NUAK2 complementarily function in the apical constriction and apico-basal elongation that associate with the dorsolateral hinge point formation in cephalic neural plate during the 5- to 10-somite stages.

  5. Data show that SNARK is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle.

  6. Obesity was a risk factor for colorectal tumorigenesis in Snark(+/-) mice model.

Profil protéine NUAK Family, SNF1-Like Kinase, 2 (NUAK2)

Profil protéine

Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95- activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1 (By similarity).

Gene names and symbols associated with NUAK2

  • NUAK family kinase 2 (NUAK2)
  • NUAK family, SNF1-like kinase, 2 (Nuak2)
  • NUAK family kinase 2 (Nuak2)
  • 1200013b22rik Protéine
  • mKIAA0537 Protéine
  • Omphk2 Protéine
  • Snark Protéine
  • UV126 Protéine

Protein level used designations for NUAK2

NUAK family SNF1-like kinase 2 , SNF1/AMP activated protein kinase , SNF1/AMP kinase-related kinase , omphalocele kinase 2 , SNF1/AMP-activated protein kinase

GENE ID SPECIES
81788 Homo sapiens
74137 Mus musculus
488570 Canis lupus familiaris
518632 Bos taurus
289419 Rattus norvegicus
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