Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) Protéines (NPR2)

NPR2 encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. De plus, nous expédions NPR2 Anticorps (83) et NPR2 Kits (23) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
NPR2 230103 Q6VVW5
NPR2 4882 P20594
NPR2 116564 P16067
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Showing 10 out of 20 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,626.73
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,626.73
Détails
Escherichia coli (E. coli) Humain His-SUMO Tag 100 μg Connectez-vous pour afficher 11 Days
$411.40
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Levure Humain His tag 100 μg Connectez-vous pour afficher 8 to 11 Days
$484.00
Détails
Levure Souris His tag 100 μg Connectez-vous pour afficher 8 to 11 Days
$578.60
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Escherichia coli (E. coli) Souris GST tag 100 μg Connectez-vous pour afficher 11 Days
$581.90
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Mammalian Cells Humain His tag 100 μg Connectez-vous pour afficher 2 to 3 Days
$1,490.50
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Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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Levure REACT_Eel His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,234.00
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Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,237.67
Détails

NPR2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine) , ,
, ,
Human , , , , , ,
, , ,
Rat (Rattus)

Plus protéines pour Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) (NPR2) partenaires d'interaction

Mouse (Murine) Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) (NPR2) interaction partners

  1. the present study indicates that CNP and its cognate receptor NPR2 mainly expressed in neurons represent an innate neuroprotective mechanism in neonatal hypoxia-ischemia brain injury.

  2. The authors show that fibroblast growth factor-induced dephosphorylation of NPR2 decreases its guanylyl cyclase activity in growth plate chondrocytes in living bone.

  3. E2-ERs system was functional in maintaining oocyte meiotic arrest by regulating the expression of natriuretic peptide C and natriuretic peptide receptor 2 (NPPC/NPR2)

  4. NPR2 is involved in FSH-mediated oocyte meiotic resumption, and this process is associated with the EGFR and MAPK3/1 signaling pathways.

  5. NPR2 dephosphorylation in the mural granulosa cells is essential for the normal progression of meiosis in response to LH and EGF receptor activation.

  6. Npr2 is necessary for the precise spatial organization typical of central auditory circuits, but signals are still transmitted with normal timing, and that mutant mice can hear even with these deficits.

  7. Npr2 is expressed in hard calluses of wild-type mice, suggesting a possible role of CNP signaling in fracture repair, especially in bone remodeling stage.

  8. Data, including data from mutant mice strain Npr2(slw/slw), suggest that Npr2 is critical for fertility but role of Npr2 may be more involved in penile function rather than involved in spermatogenesis.

  9. These findings demonstrate that pNPPB may be used as a probe to identify the essential amino acid sequences for activation of NPR2.

  10. GATA2 and Lmo2 cooperatively regulate VEGF-induced angiogenesis and lymphangiogenesis via NRP2.

  11. Data suggest that epidermal growth factor (Egf)/Egf receptor signaling in cumulus cells (CC) down-regulates Npr2, decreases cGMP, elevates calcium, and induces meiotic resumption/oogenesis in cultured CC-oocyte complexes (in induced meiotic arrest).

  12. CNP/NPR2 signaling is essential for oocyte meiotic arrest in early antral follicles and activated LH/amphiregulin/EGFR signaling pathway suppresses this signal by downregulating Nppc expression.

  13. NPPC/NPR2 signaling is essential for oocyte meiotic arrest and cumulus oophorus formation, which affects female fertility through the production of oocytes with developmental capacity.

  14. Cellular exposure to Go6976 reduced basal and natriuretic peptide-dependent, but not detergent-dependent, GC-A and GC-B activity.

  15. These observations suggest that the CNP/GC-B system participates in regulation of adipogenesis, particularly at an early stage in the process.

  16. Data suggest that the gastrointestinal tract dysfunction phenotype of slw/slw mice is because of a C-type natriuretic peptide/natriuretic peptide receptor B-signaling defect caused by an Npr2 mutation.

  17. findings show mural granulosa cells express Nppc mRNA; cumulus cells surrounding oocytes express mRNA of NPPC receptor NPR2; granulosa cell ligand NPPC and receptor NPR2 in cumulus cells prevent precocious meiotic maturation

  18. regulation by alternative splicing

  19. alterations in the renal CNP/NPR-B system may be an important physiological adjustment when water is scarce

  20. hyperosmotic and lysophosphatidic acid-dependent inhibition of NPRB is mediated by calcium-dependent phosphorylation

Human Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) (NPR2) interaction partners

  1. These results of the distinct presence of NPRA and NPRBpositive cells in unstable plaques underlying acute myocardial infarction suggested that natriuretic peptides serve a role in regulating plaque instability in humans.

  2. Atenolol treatment normalized the altered expression of Npr1 and Npr2 genes.

  3. Data suggest mutations in NPR2 in patients with skeletal overgrowth alter conformation: A488P/R655C missense mutations yield conformation mimicking allosterically activated NPR2; A488P mutation sets phosphorylation as requirement for CNP-dependent activation; R655C mutation abrogates need for phosphorylation; ATP analog inhibits mutants. (NPR2 = atrial natriuretic factor receptor B; CNP = C-type natriuretic peptide)

  4. in 4 Indian families with acromesomelic dysplasia, type Maroteaux, 4 homozygous mutations in four different families were identified; these include 3 novel mutations including a deletion frameshift mutation (p.Cys586Ter), one nonsense mutation (p.Arg479Ter), one missense mutation (p.Val187Asp) and one reported missense mutation (p.Tyr338Cys)

  5. Heterozygous mutation in NPR2 gene is associated with short stature.

  6. Mutations in three genes (GDF5, NPR2, BMPR1B) have been reported to cause different forms of acromesomelic dysplasia

  7. IL1R2 hypomethylation and androgen receptor hypermethylation may constitute an important determinant of disease severity, whereas NPR2 hypomethylation and SP140 hypermethylation may provide a biomarker for vulnerability to excessive daytime sleepiness in Obstructive Sleep Apnea

  8. Loss-of-function mutations of the NPR2 gene is associated with acromesomelic dysplasia, type maroteaux.

  9. Heterozygous mutations in natriuretic peptide receptor-B (NPR2) gene as a cause of short stature

  10. NPR2 mutations account for approximately 3% of patients with disproportionate short stature and/or clinical or radiographic indicators of SHOX deficiency and in whom no SHOX defect has been identified.

  11. 3 consanguineous families segregating Acromesomelic dysplasia Maroteaux type in an autosomal recessive manner studied. Linkage in the families was established to the NPR2 gene on chromosome 9p12-21. Sequence analysis revealed 2 novel missense variants (p.Arg601Ser; p.Arg749Trp) in 2 families and a previously reported splice site variant (c.2986+2T>G) in the third family.

  12. Cardiac fibrosis and the endogenous natriuretic peptide system were evaluated in end-stage heart failure to assess the anti-fibrotic actions of the dual GC-A/-B activator.

  13. Overgrowth syndrome associated with a gain-of-function mutation of the natriuretic peptide receptor 2 (NPR2) gene.

  14. Gene expression of C-type natriuretic peptide and of its specific receptor NPR-B in human leukocytes of healthy and heart failure subjects

  15. Molecular dynamics analysis indicated decreases in the values of Van der Waals, electrostatic energy and potential energy of NPRB/Vasonatrin peptide compared to NPRA/Vasonatrin peptide.

  16. Identification of heterozygous dominant negative NPR2 mutations in 2% of Japanese patients with short stature.

  17. KIdney NPR2 protein quantity is significantly impacted by genetic variation.

  18. study concludes V883M mutation increases maximal velocity in absence of C-type natriuretic peptide (CNP), eliminates requirement for ATP in the CNP-dependent Km reduction and disrupts normal inactivation process; established a molecular mechanism for how an amino acid substitution in GC-B activates the enzyme, which results in abnormally long and fragile bones

  19. In transgenic mice, complete absence of Npr2 activity prohibits the bifurcation of cranial sensory axons.

  20. Although no novel phosphorylation sites that influenced the suppression of guanylate cyclase-B were identified, experiments revealed that mutations in Tyr808 markedly enhanced GC-B activity.

Cow (Bovine) Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) (NPR2) interaction partners

  1. These data support the existence of a novel transducing cascade, involving Galpha(q16)beta gamma coupling M(3)AChR to NPR-GC.

  2. NPR-B is a highly regulated nano-machinery with domains acting at cross-talk points with other signal transducing cascades initiated by G protein-coupled receptors

  3. ATP is not required for the initial activation of natriuretic peptide receptor A and B, but does increase activity over time by reducing the apparent K(m) for GTP.

Profil protéine NPR2

Profil protéine

This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.

Gene names and symbols associated with NPR2

  • natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) (NPR2)
  • natriuretic peptide receptor 2 (Npr2)
  • natriuretic peptide receptor 2 (NPR2)
  • AMDM Protéine
  • ANPb Protéine
  • ANPRB Protéine
  • cn Protéine
  • GC-B Protéine
  • GC-B2 Protéine
  • GC-B3 Protéine
  • GUC2B Protéine
  • GUCY2B Protéine
  • mNPR-B Protéine
  • NPR-B Protéine
  • NPR2 Protéine
  • NPRB Protéine
  • NPRBi Protéine
  • pwe Protéine

Protein level used designations for NPR2

natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) , natriuretic peptide receptor 2 , ANP-B , ANPR-B , NPR-B , Nppb receptor , atrial natriuretic peptide receptor 2 , atrial natriuretic peptide receptor type B , guanylate cyclase B , guanylyl cyclase-B , natriuretic peptide receptor B type , GC-B , atrial natriuretic peptide B-type receptor , ANPRB , atrial natriuretic peptide receptor B , natriuretic peptide receptor-B , atrionatriuretic peptide receptor B

GENE ID SPECIES
692193 Sus scrofa
230103 Mus musculus
4882 Homo sapiens
116564 Rattus norvegicus
281357 Bos taurus
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