Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) Protéines (NPR2)

NPR2 encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. De plus, nous expédions NPR2 Anticorps (84) et NPR2 Kits (23) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
NPR2 230103 Q6VVW5
NPR2 4882 P20594
NPR2 116564 P16067
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Top NPR2 Protéines sur anticorps-enligne.fr

Showing 10 out of 20 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,797.11
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,797.11
Détails
Escherichia coli (E. coli) Humain His-SUMO Tag 100 μg Connectez-vous pour afficher 11 Days
$411.40
Détails
Levure Humain His tag 100 μg Connectez-vous pour afficher 8 to 11 Days
$484.00
Détails
Levure Souris His tag 100 μg Connectez-vous pour afficher 8 to 11 Days
$578.60
Détails
Escherichia coli (E. coli) Souris GST tag 100 μg Connectez-vous pour afficher 11 Days
$581.90
Détails
Mammalian Cells Humain His tag 100 μg Connectez-vous pour afficher 2 to 3 Days
$1,490.50
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
Levure REACT_Eel His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,234.00
Détails
Levure Boeuf (Vache) His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,237.67
Détails

NPR2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine) , ,
, ,
Human , , , , , ,
, , ,
Rat (Rattus)

Plus protéines pour Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) (NPR2) partenaires d'interaction

Mouse (Murine) Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) (NPR2) interaction partners

  1. The authors show that fibroblast growth factor-induced dephosphorylation of NPR2 (Montrer NPRL2 Protéines) decreases its guanylyl cyclase activity in growth plate chondrocytes in living bone.

  2. E2-ERs system was functional in maintaining oocyte meiotic arrest by regulating the expression of natriuretic peptide C and natriuretic peptide receptor 2 (NPPC/NPR2 (Montrer NPRL2 Protéines))

  3. NPR2 (Montrer NPRL2 Protéines) is involved in FSH (Montrer BRD2 Protéines)-mediated oocyte meiotic resumption, and this process is associated with the EGFR (Montrer EGFR Protéines) and MAPK3 (Montrer MAPK3 Protéines)/1 signaling pathways.

  4. NPR2 (Montrer NPRL2 Protéines) dephosphorylation in the mural granulosa cells is essential for the normal progression of meiosis in response to LH and EGF receptor (Montrer EGFR Protéines) activation.

  5. Npr2 (Montrer NPRL2 Protéines) is necessary for the precise spatial organization typical of central auditory circuits, but signals are still transmitted with normal timing, and that mutant mice can hear even with these deficits.

  6. Npr2 (Montrer NPRL2 Protéines) is expressed in hard calluses of wild-type mice, suggesting a possible role of CNP (Montrer CNP Protéines) signaling in fracture repair, especially in bone remodeling stage.

  7. Data, including data from mutant mice strain Npr2 (Montrer NPRL2 Protéines)(slw/slw), suggest that Npr2 (Montrer NPRL2 Protéines) is critical for fertility but role of Npr2 (Montrer NPRL2 Protéines) may be more involved in penile function rather than involved in spermatogenesis.

  8. These findings demonstrate that pNPPB may be used as a probe to identify the essential amino acid sequences for activation of NPR2 (Montrer NPRL2 Protéines).

  9. GATA2 (Montrer GATA2 Protéines) and Lmo2 (Montrer LMO2 Protéines) cooperatively regulate VEGF (Montrer VEGFA Protéines)-induced angiogenesis and lymphangiogenesis via NRP2 (Montrer NRP2 Protéines).

  10. Data suggest that epidermal growth factor (Egf)/Egf (Montrer EGF Protéines) receptor (Montrer EGFR Protéines) signaling in cumulus cells (CC) down-regulates Npr2 (Montrer NPRL2 Protéines), decreases cGMP, elevates calcium, and induces meiotic resumption/oogenesis in cultured CC-oocyte complexes (in induced meiotic arrest).

Human Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) (NPR2) interaction partners

  1. These results of the distinct presence of NPRA (Montrer NPR1 Protéines) and NPRBpositive cells in unstable plaques underlying acute myocardial infarction suggested that natriuretic peptides serve a role in regulating plaque instability in humans.

  2. Atenolol treatment normalized the altered expression of Npr1 (Montrer NPR1 Protéines) and Npr2 (Montrer NPRL2 Protéines) genes.

  3. Data suggest mutations in NPR2 in patients with skeletal overgrowth alter conformation: A488P/R655C missense mutations yield conformation mimicking allosterically activated NPR2; A488P mutation sets phosphorylation as requirement for CNP-dependent activation; R655C mutation abrogates need for phosphorylation; ATP analog inhibits mutants. (NPR2 = atrial natriuretic factor receptor B; CNP = C-type natriuretic peptide)

  4. Heterozygous mutation in NPR2 (Montrer NPRL2 Protéines) gene is associated with short stature.

  5. Mutations in three genes (GDF5 (Montrer GDF5 Protéines), NPR2 (Montrer NPRL2 Protéines), BMPR1B (Montrer BMPR1B Protéines)) have been reported to cause different forms of acromesomelic dysplasia

  6. IL1R2 (Montrer IL1R2 Protéines) hypomethylation and androgen receptor (Montrer AR Protéines) hypermethylation may constitute an important determinant of disease severity, whereas NPR2 (Montrer NPRL2 Protéines) hypomethylation and SP140 (Montrer SP140 Protéines) hypermethylation may provide a biomarker for vulnerability to excessive daytime sleepiness in Obstructive Sleep Apnea

  7. Loss-of-function mutations of the NPR2 (Montrer NPRL2 Protéines) gene is associated with acromesomelic dysplasia, type maroteaux.

  8. NPR2 (Montrer NPRL2 Protéines) mutations account for approximately 3% of patients with disproportionate short stature and/or clinical or radiographic indicators of SHOX (Montrer SHOX Protéines) deficiency and in whom no SHOX (Montrer SHOX Protéines) defect has been identified.

  9. 3 consanguineous families segregating Acromesomelic dysplasia Maroteaux type in an autosomal recessive manner studied. Linkage in the families was established to the NPR2 (Montrer NPRL2 Protéines) gene on chromosome 9p12-21. Sequence analysis revealed 2 novel missense variants (p.Arg601Ser; p.Arg749Trp) in 2 families and a previously reported splice site variant (c.2986+2T>G) in the third family.

  10. Cardiac fibrosis and the endogenous natriuretic peptide system were evaluated in end-stage heart failure to assess the anti-fibrotic actions of the dual GC-A (Montrer NPR1 Protéines)/-B activator.

Cow (Bovine) Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) (NPR2) interaction partners

  1. These data support the existence of a novel transducing cascade, involving Galpha (Montrer SUCLG1 Protéines)(q16)beta gamma coupling M(3)AChR to NPR (Montrer NPTXR Protéines)-GC.

  2. NPR-B is a highly regulated nano-machinery with domains acting at cross-talk points with other signal transducing cascades initiated by G protein-coupled receptors

  3. ATP is not required for the initial activation of natriuretic peptide receptor A (Montrer NPR1 Protéines) and B, but does increase activity over time by reducing the apparent K(m) for GTP (Montrer AK3 Protéines).

Profil protéine NPR2

Profil protéine

This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.

Gene names and symbols associated with NPR2

  • natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) (NPR2)
  • natriuretic peptide receptor 2 (Npr2)
  • natriuretic peptide receptor 2 (NPR2)
  • AMDM Protéine
  • ANPb Protéine
  • ANPRB Protéine
  • cn Protéine
  • GC-B Protéine
  • GC-B2 Protéine
  • GC-B3 Protéine
  • GUC2B Protéine
  • GUCY2B Protéine
  • mNPR-B Protéine
  • NPR-B Protéine
  • NPR2 Protéine
  • NPRB Protéine
  • NPRBi Protéine
  • pwe Protéine

Protein level used designations for NPR2

natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) , natriuretic peptide receptor 2 , ANP-B , ANPR-B , NPR-B , Nppb receptor , atrial natriuretic peptide receptor 2 , atrial natriuretic peptide receptor type B , guanylate cyclase B , guanylyl cyclase-B , natriuretic peptide receptor B type , GC-B , atrial natriuretic peptide B-type receptor , ANPRB , atrial natriuretic peptide receptor B , natriuretic peptide receptor-B , atrionatriuretic peptide receptor B

GENE ID SPECIES
692193 Sus scrofa
230103 Mus musculus
4882 Homo sapiens
116564 Rattus norvegicus
281357 Bos taurus
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