Nebulette Protéines (NEBL)

NEBL encodes a nebulin like protein that is abundantly expressed in cardiac muscle. De plus, nous expédions Nebulette Anticorps (32) et Nebulette Kits (6) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
Rat NEBL NEBL 307189  
NEBL 10529 O76041
NEBL 74103 Q9DC07
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Showing 4 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,465.26
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,869.04
Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
Détails

NEBL Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine) ,

Plus protéines pour Nebulette (NEBL) partenaires d'interaction

Human Nebulette (NEBL) interaction partners

  1. LASP2 may play a significant role in suppressing CRC (Montrer CALR Protéines) progression and provided a novel biomarker for CRC (Montrer CALR Protéines) therapy

  2. The levels of phosphorylated FAK (Montrer PTK2 Protéines) (Tyr397 and Tyr925) were increased after overexpressing Lasp2 and were downregulated by transfecting Lasp2-siRNA.

  3. predisposition to multibacillary leprosy in Vietnam is associated with CUBN (Montrer CUBN Protéines) and NEBL common variants in the chromosome 10p13 linkage region

  4. We identify the SH3 domains of nebulin and nebulette as novel ligands of proline-rich regions of Xin and XIRP2

  5. Data indicate that lasp-2 interacts with the focal adhesion proteins vinculin (Montrer VCL Protéines) and paxillin (Montrer PXN Protéines).

  6. Report oncogenic potential of MLL (Montrer MLL Protéines)-NEBL and NEBL-MLL (Montrer MLL Protéines) fusion genes in acute myeloid leukemia (Montrer BCL11A Protéines).

  7. Different mutations in nebulette transgene trigger a pathological cascade leading to endocardial fibroelastosis and dilated cardiomyopathy in mutant embryonic mouse hearts.

  8. our data demonstrate the importance of this cardiac-specific nebulin isoform in myofibril organization and function. Our data demonstrate that nebulette plays a significant role in the structure and stability of the cardiac Z-line.

  9. LIM-nebulette, Lasp-1 (Montrer LASP1 Protéines), and zyxin (Montrer ZYX Protéines) may play an important role in the organization of focal adhesions

  10. filamin-C (Montrer FLNC Protéines), a known component of striated (Montrer NSDHL Protéines) muscle Z-lines, interacts with nebulette modules

Mouse (Murine) Nebulette (NEBL) interaction partners

  1. the nebulette disease causing mutations have dominant gain-of-function effects

  2. This study showed distinct effects of NEBL mutations on sarcomere ultrastructure, cellular contractile function, and calcium homeostasis in preclinical DCM in vivo.

  3. Actin filament binding activity may be a major contributor to the subcellular localization of lasp-2 to filopodia but is not crucial for lasp-2 recruitment to focal adhesions [lasp-2]

  4. LIM-nebulette, Lasp-1 (Montrer LASP1 Protéines), and zyxin (Montrer ZYX Protéines) may play an important role in the organization of focal adhesions [LIM-nebulette]

Profil protéine Nebulette (NEBL)

Profil protéine

This gene encodes a nebulin like protein that is abundantly expressed in cardiac muscle. The encoded protein binds actin and interacts with thin filaments and Z-line associated proteins in striated muscle. This protein may be involved in cardiac myofibril assembly. A shorter isoform of this protein termed LIM nebulette is expressed in non-muscle cells and may function as a component of focal adhesion complexes. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with Nebulette Protéines (NEBL)

  • nebulette (Nebl)
  • nebulette (NEBL)
  • nebulette (nebl)
  • nebulette S homeolog (nebl.S)
  • 1200007O21Rik Protéine
  • A630080F05Rik Protéine
  • BB140644 Protéine
  • D830029A09Rik Protéine
  • LASP-2 Protéine
  • LASP2 Protéine
  • Lnebl Protéine
  • zgc:113144 Protéine

Protein level used designations for Nebulette Protéines (NEBL)

LIM and SH3 protein , nebulette , LIM-nebulette , actin-binding Z-disk protein

GENE ID SPECIES
307189 Rattus norvegicus
395148 Gallus gallus
517987 Bos taurus
541446 Danio rerio
702764 Macaca mulatta
740056 Pan troglodytes
100019946 Monodelphis domestica
100055848 Equus caballus
100078834 Ornithorhynchus anatinus
100127275 Xenopus laevis
100343234 Oryctolagus cuniculus
100414047 Callithrix jacchus
100454212 Pongo abelii
100463626 Ailuropoda melanoleuca
100496676 Xenopus (Silurana) tropicalis
100522395 Sus scrofa
100551611 Anolis carolinensis
100582784 Nomascus leucogenys
10529 Homo sapiens
74103 Mus musculus
477974 Canis lupus familiaris
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