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NEBL encodes a nebulin like protein that is abundantly expressed in cardiac muscle. De plus, nous expédions Nebulette Anticorps (32) et Nebulette Kits (6) et beaucoup plus de produits pour cette protéine.
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LASP2 may play a significant role in suppressing CRC (Montrer CALR Protéines) progression and provided a novel biomarker for CRC (Montrer CALR Protéines) therapy
The levels of phosphorylated FAK (Montrer PTK2 Protéines) (Tyr397 and Tyr925) were increased after overexpressing Lasp2 and were downregulated by transfecting Lasp2-siRNA.
predisposition to multibacillary leprosy in Vietnam is associated with CUBN (Montrer CUBN Protéines) and NEBL common variants in the chromosome 10p13 linkage region
We identify the SH3 domains of nebulin and nebulette as novel ligands of proline-rich regions of Xin and XIRP2
Data indicate that lasp-2 interacts with the focal adhesion proteins vinculin (Montrer VCL Protéines) and paxillin (Montrer PXN Protéines).
Report oncogenic potential of MLL (Montrer MLL Protéines)-NEBL and NEBL-MLL (Montrer MLL Protéines) fusion genes in acute myeloid leukemia (Montrer BCL11A Protéines).
Different mutations in nebulette transgene trigger a pathological cascade leading to endocardial fibroelastosis and dilated cardiomyopathy in mutant embryonic mouse hearts.
our data demonstrate the importance of this cardiac-specific nebulin isoform in myofibril organization and function. Our data demonstrate that nebulette plays a significant role in the structure and stability of the cardiac Z-line.
LIM-nebulette, Lasp-1 (Montrer LASP1 Protéines), and zyxin (Montrer ZYX Protéines) may play an important role in the organization of focal adhesions
filamin-C (Montrer FLNC Protéines), a known component of striated (Montrer NSDHL Protéines) muscle Z-lines, interacts with nebulette modules
the nebulette disease causing mutations have dominant gain-of-function effects
This study showed distinct effects of NEBL mutations on sarcomere ultrastructure, cellular contractile function, and calcium homeostasis in preclinical DCM in vivo.
Actin filament binding activity may be a major contributor to the subcellular localization of lasp-2 to filopodia but is not crucial for lasp-2 recruitment to focal adhesions [lasp-2]
LIM-nebulette, Lasp-1 (Montrer LASP1 Protéines), and zyxin (Montrer ZYX Protéines) may play an important role in the organization of focal adhesions [LIM-nebulette]
This gene encodes a nebulin like protein that is abundantly expressed in cardiac muscle. The encoded protein binds actin and interacts with thin filaments and Z-line associated proteins in striated muscle. This protein may be involved in cardiac myofibril assembly. A shorter isoform of this protein termed LIM nebulette is expressed in non-muscle cells and may function as a component of focal adhesion complexes. Alternate splicing results in multiple transcript variants.
LIM and SH3 protein
, actin-binding Z-disk protein