Nemo-Like Kinase Protéines

Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination.

Qualité de données
  • 7
Type
  • 10
    Protéine
Antigène
  • 10
Réactivité
  • 8
  • 1
  • 1
Application
  • 5
  • 5
  • 5
  • 4
  • 2
Hote
  • 5
  • 2
  • 1
  • 1
  • 1
Epitope
  • 3
  • 2
  • 1
  • 1
  • 1
Conjugué
  • 4
  • 3
  • 1
  • 1
  • 1
Type Proteine
  • 10
Format
  • 6
  • 1
Activité biologique
  • 2
10 Produits
Recombinant Protéine, Cellules d'insectes (Source), Pureté >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivitéSouris
Application Crys, ELISA, SDS, WB
Détails de la commande Cat. No. ABIN3131814
$9,371.15
Plus frais de port $45.00 et $22.00 pour carboglace
Envoi sous 60 jours ouvrables
Recombinant Protéine, Cellules d'insectes (Source), Pureté >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivitéHumain
Application Crys, ELISA, SDS, WB
Détails de la commande Cat. No. ABIN3094173
$9,371.15
Plus frais de port $45.00 et $22.00 pour carboglace
Envoi sous 60 jours ouvrables
Recombinant Protéine, Wheat germ (Source)
ReactivitéHumain
Application AP, AA, KAA, ELISA, WB
Détails de la commande Cat. No. ABIN1312656
$414.29
Plus frais de port $45.00 et $22.00 pour carboglace
Envoi sous 11 à 12 jours ouvrables
Recombinant Protéine, Cellules d'insectes (Source)
ReactivitéHumain
Application Func, SDS
Détails de la commande Cat. No. ABIN5569787
$516.00
5 μg
Plus shipping costs $45.00
Envoi sous 11 à 12 jours ouvrables
Recombinant Protéine, Cellules d'insectes (Source)
ReactivitéHumain
Application Func, SDS
Détails de la commande Cat. No. ABIN5570569
$1,502.67
100 μg
Plus shipping costs $45.00
Envoi sous 11 à 12 jours ouvrables
Recombinant Protéine, Wheat germ (Source)
ReactivitéHumain
Application AP, AA, ELISA, WB
Détails de la commande Cat. No. ABIN1312658
$414.29
Plus frais de port $45.00 et $22.00 pour carboglace
Envoi sous 11 à 12 jours ouvrables
Recombinant Protéine, HEK-293 Cells (Source), Pureté > 80 % as determined by SDS-PAGE and Coomassie blue staining
ReactivitéHumain
Application AbP, Func, PI, STD
Détails de la commande Cat. No. ABIN2727385
$888.80
20 μg
Plus frais de port $45.00 et $22.00 pour carboglace
Envoi sous 11 jours ouvrables
Recombinant Protéine, Cellules d'insectes (Source), Pureté 70 % - 90 %
ReactivitéHumain
Application Func
Détails de la commande Cat. No. ABIN5509048
$340.00
10 μg
Plus shipping costs $45.00
Envoi sous 3 à 4 jours ouvrables
Recombinant Protéine, Baculovirus infected Insect Cells (Source), Pureté > 91 % as determined by SDS-PAGE
ReactivitéHumain
Application Func, SDS
Détails de la commande Cat. No. ABIN2004379
ISO
$388.88
Plus shipping costs $45.00
Envoi sous 14 à 16 jours ouvrables
Recombinant Protéine, Levure (Source), Pureté > 90 %
ReactivitéRat (Rattus)
Application ELISA
Détails de la commande Cat. No. ABIN1509815
$3,501.67
1 mg
Plus shipping costs $45.00
Envoi sous 60 à 71 jours ouvrables
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Profil protéine Nemo-Like Kinase (NLK)

Profil protéine

Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1 (By similarity).

Gene names and symbols associated with Nemo-Like Kinase Protéines (NLK)

  • glucose-6-phosphate isomerase (Gpi) anticorps
  • nemo like kinase (NLK) anticorps
  • nemo like kinase (Nlk) anticorps
  • nemo-like kinase, type 1 (nlk1) anticorps
  • nemo-like kinase L homeolog (nlk.L) anticorps
  • nemo like kinase (nlk) anticorps
  • Nemo-Like kinase (nemo-like) anticorps
  • nemo-like kinase (nlk) anticorps
  • AI194375 anticorps
  • Amf anticorps
  • Gpi1 anticorps
  • nemo-like anticorps
  • NLK anticorps
  • nlk1 anticorps
  • nlk2 anticorps
  • nlkb anticorps
  • RGD1561602 anticorps
  • Xnlk anticorps
  • zgc:111875 anticorps

Protein level used designations for Nemo-Like Kinase Protéines (NLK)

NLK , PGI , PHI , autocrine motility factor , glucose phosphate isomerase , neuroleukin , phosphoglucose isomerase , phosphohexose isomerase , serine/threonine-protein kinase NLK , nemo-like kinase , serine/threonine protein kinase NLK , nemo like kinase b , nemo-like kinase 2 , Nemo-like kinase , Serine/threonine-protein kinase NLK , nemo like kinase , Nemo-Like kinase , serine/threonine-protein kinase NLK-like

GENE ID SPECIES
292804 Rattus norvegicus
51701 Homo sapiens
18099 Mus musculus
405892 Danio rerio
414522 Xenopus laevis
417669 Gallus gallus
445934 Takifugu rubripes
491160 Canis lupus familiaris
507204 Bos taurus
677693 Macaca mulatta
739132 Pan troglodytes
778685 Ciona intestinalis
100019356 Monodelphis domestica
100058876 Equus caballus
100144638 Xenopus (Silurana) tropicalis
100348930 Oryctolagus cuniculus
100414864 Callithrix jacchus
100469296 Ailuropoda melanoleuca
100511657 Sus scrofa
100560802 Anolis carolinensis
100593981 Nomascus leucogenys
497961 Rattus norvegicus
100729077 Cavia porcellus