anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) Anticorps

displays differential expression after induction by nerve growth factor [RGD, Feb 2006].. De plus, nous expédions NEDD8 Protéines (29) et NEDD8 Kits (6) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
NEDD8 4738 Q15843
NEDD8 18002 P29595
NEDD8 25490 Q71UE8
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Top anti-NEDD8 Anticorps sur anticorps-enligne.fr

Showing 10 out of 129 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué IHC (p), WB NEDD8 was detected in paraffin-embedded sections of human lung cancer tissues using rabbit anti- NEDD8 Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). Western blot analysis of NEDD8 expression in rat testis extract ( Lane 1), mouse thymus extract ( Lane 2), mouse brain extract ( Lane 3), HELA whole cell lysates ( Lane 4) and MCF-7 whole cell lysates ( Lane 5). NEDD8 at 9KD was detected using rabbit anti- NEDD8 Antigen Affinity purified polyclonal antibody (Catalog #) at 0.5 µg/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg Connectez-vous pour afficher 4 to 6 Days
$280.00
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of NEDD8 polyclonal antibody (ABIN388037) in HeLa cell lysate. NEDD8 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Connectez-vous pour afficher 10 to 11 Days
$335.50
Détails
Humain Souris Inconjugué ELISA, FACS, IF/ICC, IHC, WB 100 μg Connectez-vous pour afficher 11 to 16 Days
$426.40
Détails
Boeuf (Vache) Lapin Inconjugué IP, IHC, WB Immunohistochemical analysis of NEDD8 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of NEDD8 expression in BJAB (A), K562 (B), HeLa (C) whole cell lysates. 200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails
Humain Souris Inconjugué ELISA, FACS, ICC, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 1: Western blot analysis using NEDD8 mAb against human NEDD8 (AA: 1-81) recombinant protein. (Expected MW is 40 kDa)  Dilution: 1/500 - 1/2000 100 μL Connectez-vous pour afficher 8 to 11 Days
$561.00
Détails
Humain Souris Inconjugué ELISA, FACS, IF, IHC, WB 100 μg Connectez-vous pour afficher 7 to 9 Days
$551.83
Détails
Humain Lapin Inconjugué IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells, using NEDD8 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using NEDD8 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Connectez-vous pour afficher 2 to 3 Days
$302.50
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$390.50
Détails
Humain Souris Inconjugué CyTOF, ELISA, FACS, ICC, IF, IHC, WB Flow Cytometry: NEDD8 Antibody (1A7) [NBP2-37524] - Flow cytometric analysis of Hela cells using NEDD8 mouse mAb (green) and negative control (red). Western Blot: NEDD8 Antibody (1A7) [NBP2-37524] - Western blot analysis using NEDD8 mAb against human NEDD8 (AA: 1-81) recombinant protein. (Expected MW is 40 kDa) 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$514.63
Détails
Humain Lapin Inconjugué ELISA, IHC, IHC (p), WB Anti-NEDD8 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959353 dilution 1:100. 50 μL Connectez-vous pour afficher 7 to 9 Days
$484.00
Détails

anti-NEDD8 Anticorps mieux référencés

  1. Human Monoclonal NEDD8 Primary Antibody pour ICC, FACS - ABIN969547 : Ohki, Funatsu, Konishi, Chiba: The mechanism of poly-NEDD8 chain formation in vitro. dans Biochemical and biophysical research communications 2009 (PubMed)

Plus d’anticorps contre NEDD8 partenaires d’interaction

Human Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) interaction partners

  1. Nedd8 binding to Smurf plays important roles in the regulation of cell migration and the BMP and TGFbeta (Montrer TGFB1 Anticorps) signaling pathways.

  2. NEDD8-mediated neddylation promotes stress granule assembly.

  3. NEDD8 seems to inhibit the Src (Montrer SRC Anticorps)-mediated phosphorylation of caveolin-1 (Montrer CAV1 Anticorps) by modifying the structure of caveolin-1 (Montrer CAV1 Anticorps) protein, which blocks the migration of cancer cells. Although the neddylation process is currently regarded as an emerging target for cancer therapy, our results suggest the possibility that the inhibition of neddylation could facilitate cancer invasion or metastasis at least in some types of cancers.

  4. The cellular effects of NEDD8 inhibition can be manipulated based on the p53 (Montrer TP53 Anticorps) status.

  5. Here we report that high expression of neddylation components, NEDD8 and NAE1 (Montrer NAE1 Anticorps), are associated with poor survival of Pancreatic ductal adenocarcinoma patients. Blockage of neddylation by MLN4924 significantly sensitizes pancreatic cancer cells to gemcitabine, reduced clonogenic survival, decreased invasion capacity, increased apoptosis and senescence

  6. Downregulation of NEDD8 enhanced the susceptibility of nasopharyngeal carcinoma cells to cisplatin and radiation.

  7. Furthermore, the authors characterized SENP8/DEN1 (Montrer SENP8 Anticorps) as the protease that counteracts Ubc12 (Montrer ube2m Anticorps) auto-neddylation, and observed aberrant neddylation of Ubc12 (Montrer ube2m Anticorps) and other NEDD8 conjugation pathway components in SENP8 (Montrer SENP8 Anticorps)-deficient cells.

  8. MKK7 (Montrer MAP2K7 Anticorps) undergoes neddylation in human breast cancer cells

  9. complete blocking of CRLs at a higher inhibitor dose-induced cytotoxicity that was amplified by knockdown of CRL (Montrer IL31RA Anticorps) regulator Cand1 (Montrer CAND1 Anticorps).

  10. In conclusion, the authors revealed that E3 ligase HDM2 promotes NEDD8 NEDDylation of HBx to enhance HBx stability and chromatin localization, which in turn favors HBx-dependent transcriptional regulation, cell proliferation, and hepatitis B virus-driven tumor growth.

Mouse (Murine) Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) interaction partners

  1. Downregulation of NEDD8 enhanced the susceptibility of nasopharyngeal carcinoma cells to cisplatin and radiation.

  2. Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.

  3. neural precursor cell expressed developmentally downregulated protein 8 (Nedd8) modification of Cul-5 (Montrer CUL5 Anticorps) is required for its interaction with TRAF6 (Montrer TRAF6 Anticorps).

  4. Our findings provide mechanistic evidence of the effects of IAP (Montrer ALPI Anticorps) antagonists in combination with NAE inhibitors, and demonstrate the potential of a new combination therapy for cancer.

  5. a role of Nedd8 in regulating caspase-1 (Montrer CASP1 Anticorps) activation following inflammasome activation

  6. Nedd8 and its associated E2 carrier protein (Ubc12 (Montrer ube2m Anticorps)) and E3-SCF (Montrer KITLG Anticorps) ligase play a key role in regulating the expression and activity of ENaC (Montrer SCNN1A Anticorps) in alveolar pneumocytes.

  7. a new regulatory mechanism of RCAN1 (Montrer RCAN1 Anticorps) function

  8. c-Cbl conjugates neural precursor cell-expressed, developmentally downregulated 8 (NEDD8), a ubiquitin-like protein, to TbetaRII at Lys556 and Lys567.

  9. The NEDD8 pathway appears to play an important role in CD4 (Montrer CD4 Anticorps)+ T-cell-mediated inflammatory responses

  10. Nedd8 and AhR (Montrer AHR Anticorps) localize to overlapping areas in the heart and spinal ganglia, raising the possibility that this interaction may play a role in organogenesis

Fruit Fly (Drosophila melanogaster) Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) interaction partners

  1. the Cul1 (Montrer CUL1 Anticorps)-based SCF (Montrer KITLG Anticorps) complex requires Nedd8 modification for the degradation processes of Ci, Arm, and CycE (Montrer CCNE1 Anticorps) in vivo

  2. Genetic analyses indicate that a balance between neddylation and deneddylation maintained by DEN1 (Montrer SENP8 Anticorps) is crucial for animal viability.

NEDD8 profil antigène

Profil protéine

displays differential expression after induction by nerve growth factor

Gene names and symbols associated with NEDD8

  • neural precursor cell expressed, developmentally down-regulated 8 (NEDD8) anticorps
  • neural precursor cell expressed, developmentally down-regulated gene 8 (Nedd8) anticorps
  • neural precursor cell expressed, developmentally down-regulated 8 (Nedd8) anticorps
  • CG10679 gene product from transcript CG10679-RB (Nedd8) anticorps
  • neural precursor cell expressed, developmentally down-regulated 8 (nedd8) anticorps
  • Nedd8 (Nedd8) anticorps
  • ubiquitin-like protein Nedd8 (nedd8) anticorps
  • neural precursor cell expressed, developmentally down-regulated 8 L homeolog (nedd8.L) anticorps
  • CG10679 anticorps
  • DDBDRAFT_0218116 anticorps
  • DDBDRAFT_0238041 anticorps
  • DDB_0218116 anticorps
  • DDB_0238041 anticorps
  • Dmel\\CG10679 anticorps
  • dNEDD8 anticorps
  • GB17785 anticorps
  • NEDD-8 anticorps
  • nedd8 anticorps
  • nedd8.S anticorps
  • Rub1 anticorps
  • si:zc14a17.5 anticorps
  • ubiquitin anticorps

Protein level used designations for NEDD8

neddylin , ubiquitin-like protein Nedd8 , NEDD-8 , NEDD8 , neural precursor cell expressed developmentally down-regulated protein 8 , neural precursor cell expressed, developmentally down-regulated gene 8 , CG10679-PA , Nedd8-PA , neural precursor cell-expressed developmentally downregulated , neural precursor cell expressed, developmentally down-regulated 8 , Nedd8 , NEDD8 protein , neural precursor cell expressed, developmentally down-regulated 8 S homeolog

GENE ID SPECIES
4738 Homo sapiens
18002 Mus musculus
25490 Rattus norvegicus
35151 Drosophila melanogaster
286796 Bos taurus
368667 Danio rerio
480265 Canis lupus familiaris
549727 Xenopus (Silurana) tropicalis
552822 Apis mellifera
715763 Macaca mulatta
8621655 Dictyostelium discoideum AX4
100009008 Oryctolagus cuniculus
100301786 Oncorhynchus mykiss
100528101 Ictalurus punctatus
100520086 Sus scrofa
446966 Xenopus laevis
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