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displays differential expression after induction by nerve growth factor [RGD, Feb 2006].. De plus, nous expédions NEDD8 Protéines (29) et NEDD8 Kits (6) et beaucoup plus de produits pour cette protéine.
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Human Monoclonal NEDD8 Primary Antibody pour ICC, FACS - ABIN969547
Ohki, Funatsu, Konishi, Chiba: The mechanism of poly-NEDD8 chain formation in vitro. dans Biochemical and biophysical research communications 2009
Nedd8 binding to Smurf plays important roles in the regulation of cell migration and the BMP and TGFbeta (Montrer TGFB1 Anticorps) signaling pathways.
NEDD8-mediated neddylation promotes stress granule assembly.
NEDD8 seems to inhibit the Src (Montrer SRC Anticorps)-mediated phosphorylation of caveolin-1 (Montrer CAV1 Anticorps) by modifying the structure of caveolin-1 (Montrer CAV1 Anticorps) protein, which blocks the migration of cancer cells. Although the neddylation process is currently regarded as an emerging target for cancer therapy, our results suggest the possibility that the inhibition of neddylation could facilitate cancer invasion or metastasis at least in some types of cancers.
The cellular effects of NEDD8 inhibition can be manipulated based on the p53 (Montrer TP53 Anticorps) status.
Here we report that high expression of neddylation components, NEDD8 and NAE1 (Montrer NAE1 Anticorps), are associated with poor survival of Pancreatic ductal adenocarcinoma patients. Blockage of neddylation by MLN4924 significantly sensitizes pancreatic cancer cells to gemcitabine, reduced clonogenic survival, decreased invasion capacity, increased apoptosis and senescence
Downregulation of NEDD8 enhanced the susceptibility of nasopharyngeal carcinoma cells to cisplatin and radiation.
Furthermore, the authors characterized SENP8/DEN1 (Montrer SENP8 Anticorps) as the protease that counteracts Ubc12 (Montrer ube2m Anticorps) auto-neddylation, and observed aberrant neddylation of Ubc12 (Montrer ube2m Anticorps) and other NEDD8 conjugation pathway components in SENP8 (Montrer SENP8 Anticorps)-deficient cells.
MKK7 (Montrer MAP2K7 Anticorps) undergoes neddylation in human breast cancer cells
complete blocking of CRLs at a higher inhibitor dose-induced cytotoxicity that was amplified by knockdown of CRL (Montrer IL31RA Anticorps) regulator Cand1 (Montrer CAND1 Anticorps).
In conclusion, the authors revealed that E3 ligase HDM2 promotes NEDD8 NEDDylation of HBx to enhance HBx stability and chromatin localization, which in turn favors HBx-dependent transcriptional regulation, cell proliferation, and hepatitis B virus-driven tumor growth.
Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.
neural precursor cell expressed developmentally downregulated protein 8 (Nedd8) modification of Cul-5 (Montrer CUL5 Anticorps) is required for its interaction with TRAF6 (Montrer TRAF6 Anticorps).
Our findings provide mechanistic evidence of the effects of IAP (Montrer ALPI Anticorps) antagonists in combination with NAE inhibitors, and demonstrate the potential of a new combination therapy for cancer.
a role of Nedd8 in regulating caspase-1 (Montrer CASP1 Anticorps) activation following inflammasome activation
Nedd8 and its associated E2 carrier protein (Ubc12 (Montrer ube2m Anticorps)) and E3-SCF (Montrer KITLG Anticorps) ligase play a key role in regulating the expression and activity of ENaC (Montrer SCNN1A Anticorps) in alveolar pneumocytes.
a new regulatory mechanism of RCAN1 (Montrer RCAN1 Anticorps) function
c-Cbl conjugates neural precursor cell-expressed, developmentally downregulated 8 (NEDD8), a ubiquitin-like protein, to TbetaRII at Lys556 and Lys567.
The NEDD8 pathway appears to play an important role in CD4 (Montrer CD4 Anticorps)+ T-cell-mediated inflammatory responses
Nedd8 and AhR (Montrer AHR Anticorps) localize to overlapping areas in the heart and spinal ganglia, raising the possibility that this interaction may play a role in organogenesis
the Cul1 (Montrer CUL1 Anticorps)-based SCF (Montrer KITLG Anticorps) complex requires Nedd8 modification for the degradation processes of Ci, Arm, and CycE (Montrer CCNE1 Anticorps) in vivo
Genetic analyses indicate that a balance between neddylation and deneddylation maintained by DEN1 (Montrer SENP8 Anticorps) is crucial for animal viability.
displays differential expression after induction by nerve growth factor
, ubiquitin-like protein Nedd8
, neural precursor cell expressed developmentally down-regulated protein 8
, neural precursor cell expressed, developmentally down-regulated gene 8
, neural precursor cell-expressed developmentally downregulated
, neural precursor cell expressed, developmentally down-regulated 8
, NEDD8 protein
, neural precursor cell expressed, developmentally down-regulated 8 S homeolog