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displays differential expression after induction by nerve growth factor [RGD, Feb 2006].. De plus, nous expédions NEDD8 Anticorps (129) et NEDD8 Protéines (29) et beaucoup plus de produits pour cette protéine.
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NEDD8-mediated neddylation promotes stress granule assembly.
NEDD8 seems to inhibit the Src (Montrer SRC Kits ELISA)-mediated phosphorylation of caveolin-1 (Montrer CAV1 Kits ELISA) by modifying the structure of caveolin-1 (Montrer CAV1 Kits ELISA) protein, which blocks the migration of cancer cells. Although the neddylation process is currently regarded as an emerging target for cancer therapy, our results suggest the possibility that the inhibition of neddylation could facilitate cancer invasion or metastasis at least in some types of cancers.
The cellular effects of NEDD8 inhibition can be manipulated based on the p53 (Montrer TP53 Kits ELISA) status.
Here we report that high expression of neddylation components, NEDD8 and NAE1, are associated with poor survival of Pancreatic ductal adenocarcinoma patients. Blockage of neddylation by MLN4924 significantly sensitizes pancreatic cancer cells to gemcitabine, reduced clonogenic survival, decreased invasion capacity, increased apoptosis and senescence
Downregulation of NEDD8 enhanced the susceptibility of nasopharyngeal carcinoma cells to cisplatin and radiation.
Furthermore, the authors characterized SENP8/DEN1 (Montrer SENP8 Kits ELISA) as the protease that counteracts Ubc12 auto-neddylation, and observed aberrant neddylation of Ubc12 and other NEDD8 conjugation pathway components in SENP8 (Montrer SENP8 Kits ELISA)-deficient cells.
MKK7 (Montrer MAP2K7 Kits ELISA) undergoes neddylation in human breast cancer cells
complete blocking of CRLs at a higher inhibitor dose-induced cytotoxicity that was amplified by knockdown of CRL (Montrer IL31RA Kits ELISA) regulator Cand1 (Montrer CAND1 Kits ELISA).
In conclusion, the authors revealed that E3 ligase HDM2 promotes NEDD8 NEDDylation of HBx to enhance HBx stability and chromatin localization, which in turn favors HBx-dependent transcriptional regulation, cell proliferation, and hepatitis B virus-driven tumor growth.
CUL5 (Montrer CUL5 Kits ELISA) neddylation may allosterically tune polyubiquitin (Montrer UBB Kits ELISA) chain length and topology.
Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.
neural precursor cell expressed developmentally downregulated protein 8 (Nedd8) modification of Cul-5 (Montrer CUL5 Kits ELISA) is required for its interaction with TRAF6 (Montrer TRAF6 Kits ELISA).
Our findings provide mechanistic evidence of the effects of IAP (Montrer ALPI Kits ELISA) antagonists in combination with NAE inhibitors, and demonstrate the potential of a new combination therapy for cancer.
a role of Nedd8 in regulating caspase-1 (Montrer CASP1 Kits ELISA) activation following inflammasome activation
Nedd8 and its associated E2 carrier protein (Ubc12) and E3-SCF (Montrer KITLG Kits ELISA) ligase play a key role in regulating the expression and activity of ENaC (Montrer SCNN1A Kits ELISA) in alveolar pneumocytes.
a new regulatory mechanism of RCAN1 (Montrer RCAN1 Kits ELISA) function
c-Cbl conjugates neural precursor cell-expressed, developmentally downregulated 8 (NEDD8), a ubiquitin-like protein, to TbetaRII at Lys556 and Lys567.
The NEDD8 pathway appears to play an important role in CD4 (Montrer CD4 Kits ELISA)+ T-cell-mediated inflammatory responses
Nedd8 and AhR (Montrer AHR Kits ELISA) localize to overlapping areas in the heart and spinal ganglia, raising the possibility that this interaction may play a role in organogenesis
the Cul1 (Montrer CUL1 Kits ELISA)-based SCF (Montrer KITLG Kits ELISA) complex requires Nedd8 modification for the degradation processes of Ci, Arm, and CycE (Montrer CCNE1 Kits ELISA) in vivo
Genetic analyses indicate that a balance between neddylation and deneddylation maintained by DEN1 (Montrer SENP8 Kits ELISA) is crucial for animal viability.
displays differential expression after induction by nerve growth factor
, ubiquitin-like protein Nedd8
, neural precursor cell expressed developmentally down-regulated protein 8
, neural precursor cell expressed, developmentally down-regulated gene 8
, neural precursor cell-expressed developmentally downregulated
, neural precursor cell expressed, developmentally down-regulated 8
, NEDD8 protein
, neural precursor cell expressed, developmentally down-regulated 8 S homeolog