Neural Precursor Cell Expressed, Developmentally Down-Regulated 9 (NEDD9) Kits ELISA

The protein encoded by NEDD9 is a member of the CRK-associated substrates family. De plus, nous expédions NEDD9 Anticorps (95) et NEDD9 Protéines (6) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
NEDD9 4739 Q14511
Anti-Rat NEDD9 NEDD9 291044  
NEDD9 18003 O35177
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 0.078 ng/mL 0.156-10 ng/mL   96 Tests 2 to 3 Days
$867.90
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Souris < 0.059 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests 11 to 18 Days
$618.29
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Plus Kits ELISA pour NEDD9 partenaires d'interaction

Human Neural Precursor Cell Expressed, Developmentally Down-Regulated 9 (NEDD9) interaction partners

  1. HEF1 expression correlates with differentiation in clinical gastric cancer tissues. HEF1 negatively relates to tumor differentiation in human gastric cancer cells. HEF1 regulates differentiation through the Wnt5a/beta-catenin signaling pathway in human gastric cancer cells.

  2. High expression level of HEF1 gene can promote the proliferation.

  3. NEDD9 is identified as a secretory biomarker for Pancreatic cancer but it has no prognostic role.

  4. results from the above studies demonstrated that ERbeta can promote NSCLC VM formation and cell invasion via altering the ERbeta/MALAT1/miR145-5p/NEDD9 signaling. Targeting this newly identified signaling pathway with small molecules may help the development of novel therapies to better suppress the NSCLC metastasis.

  5. NEDD9 variation is associated with dental caries.

  6. Tumor cell-intrinsic Nedd9 expression promotes OC development.

  7. NEDD9, E-cadherin and gamma-catenin proteins have roles in pancreatic ductal adenocarcinoma

  8. Results reveal the role of a phosphorylation-dependent HEF1-Plk1 complex in HEF1 translocation to FAs to induce cell migration.

  9. Overexpression of NEDD9 promotes cell invasion and metastasis in hepatocellular carcinoma. Also, NEDD9 may serve as potential therapeutic target for the treatment of hepatocellular carcinoma.

  10. MiR-125a-5p may serve as a therapeutic agent for lung adenocarcinoma through its major target, NEDD9.

  11. NEDD9 deregulated Smad7 expression to inhibit Smad signaling and binding to the FAK-Src-Crk complex which is proposed that this is the mechanism by which NEDD9 induced greater sphere formation in cancer stem cells properties.

  12. HIP2 regulates mitotic spindle alignment. SHIP2 is expressed in G1 phase, whereas Aurora A kinase is enriched in mitosis. SHIP2 binds Aurora A kinase and the scaffolding protein HEF1 and promotes their basolateral localization at the expense of their luminal expression connected with cilia resorption.

  13. The protein expression level of NEDD9 is higher in esophageal carcinoma tissues than that in adjacent normal tissues. Knockdown of NEDD9 expression can restrain the proliferation, invasion and migration of EC109 cells.

  14. NEDD9 was able to partially overcome the inhibitory effects of miR-203 on colorectal cancer cell colony formation and invasion.

  15. Increased NEDD9 expression is associated with metastatic endometrial and lung cancers.

  16. NEDD9 has an essential role in development as well as in neoplastic cell proliferation, apoptosis, adhesion, migration and invasion. (Review)

  17. The presence of the dna fragment in the NSCLC-N6-L16 cell ChIP assays demonstrated a physical link between NEDD9 and p53.

  18. siRNA suppression of NEDD9 inhibits proliferation and enhances apoptosis in renal cell carcinoma.

  19. Serum NEDD9 was elevated in gastric cancer patients and had an unfavorable prognostic effect.

  20. BCAR3 is an essential interactor and mediator of HEF1-induced migration.

Mouse (Murine) Neural Precursor Cell Expressed, Developmentally Down-Regulated 9 (NEDD9) interaction partners

  1. a new role for Cas-L in T-cell activation, is reported.

  2. These results suggest that Nedd9 is a Smad2/3 target gene implicated in RANKL-induced osteoclastogenesis.

  3. NEDD9 is required for the maintenance of dendritic spines in the hippocampus.

  4. NEDD9 has an essential role in development as well as in neoplastic cell proliferation, apoptosis, adhesion, migration and invasion. (Review)

  5. Thus the RARE upstream of the Nedd9 2B promoter is necessary for much of the endogenous gene expression during early development as well as ectopic expression in response to atRA.

  6. suggest that Cas-L/NEDD9 plays a pivotal role in the pathophysiology of CIA, and that Cas-L/NEDD9 may be a potential molecular target for the treatment of RA

  7. Data indicate that Src kinase modulates the transit time of NEDD9 (neural precursor cell expressed developmentally down-regulated gene 9) at focal adhesion sites.

  8. These results indicated an important modifier action of Nedd9 on autosomal dominant polycystic kidney disease pathogenesis involving failure to activate Aurora-A.

  9. these results indicate a functional requirement for NEDD9 in the growth of mammary cancer progenitor cells

  10. Tyrosine Y189 in the substrate domain of the adhesion docking protein NEDD9 is conserved with p130Cas Y253 and regulates NEDD9-mediated migration and focal adhesion dynamics.

  11. Collectively our data suggest that NEDD9 may promote 3D cell migration by slowing focal adhesion disassembly, promoting integrin receptor activation and increasing adhesion force

  12. Myosin IIA inhibition also significantly reduces phosphorylation of the mechanosensing protein CasL (Crk-associated substrate the lymphocyte type), raising the possibility of a direct mechanical mechanism of signal modulation involving CasL.

  13. Cas-L seems to regulate the progression of CML in a negative way, presumably by attenuating extramedullary hyperplasia

  14. Cas proteins do not affect E-cadherin transcription, but rather, BCAR1 and NEDD9 signal through SRC to promote E-cadherin removal from the cell membrane and lysosomal degradation.

  15. Mammary tumor cells lacking NEDD9 is associated with enhanced genetic instability and dasatinib sensitivity.

  16. SHEP1 and CasL are constitutively associated in B cells.

  17. Cas-L affects homeostasis of MZB cells and peripheral lymphoid organs, which is considered to be relevant to impaired lymphocyte migration and adhesion

  18. Nedd9 has a role in the differentiation of neurons after ischemia

  19. Cellular localization of NEDD9 expression during embryonic development.

  20. Nedd9 promotes the migration of NCCs in a graded manner and suggest a role for RA in the control of Nedd9 expression levels.

NEDD9 profil antigène

Antigen Summary

The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with NEDD9

  • neural precursor cell expressed, developmentally down-regulated 9 (NEDD9) anticorps
  • neural precursor cell expressed, developmentally down-regulated 9 (Nedd9) anticorps
  • neural precursor cell expressed, developmentally down-regulated gene 9 (Nedd9) anticorps
  • Cas-L anticorps
  • CAS2 anticorps
  • CasL anticorps
  • CASS2 anticorps
  • E230025G09Rik anticorps
  • HEF1 anticorps
  • NEDD9 anticorps

Protein level used designations for NEDD9

neural precursor cell expressed, developmentally down-regulated 9 , enhancer of filamentation 1 homolog , Cas scaffolding protein family member 2 , Crk-associated substrate related protein Cas-L , Enhancer of filamentation 1 p55 , cas-like docking , enhancer of filamentation 1 , neural precursor cell expressed developmentally down-regulated protein 9 , p130Cas-related protein , renal carcinoma antigen NY-REN-12 , neural precursor cell expressed, developmentally down-regulated gene 9 , CRK-associated substrate-related protein , Crk-associated substrate lymphocyte-specific protein , NEDD-9 , mEF1 , p105

GENE ID SPECIES
395736 Gallus gallus
462433 Pan troglodytes
100063890 Equus caballus
100154178 Sus scrofa
100229910 Taeniopygia guttata
100606649 Nomascus leucogenys
4739 Homo sapiens
291044 Rattus norvegicus
18003 Mus musculus
488220 Canis lupus familiaris
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