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Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. De plus, nous expédions NTSR1 Anticorps (90) et NTSR1 Kits (12) et beaucoup plus de produits pour cette protéine.
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The weight loss behaviors are mediated by distinct signaling pathways: Nts (Montrer NTS Protéines) action via NtsR1 is essential for the anorectic effect of the lateral hypothalamic Nts (Montrer NTS Protéines) circuit, but not for regulation of locomotor or drinking behavior.
Data demonstrate that the NTR1 can modulate the methamphetamine-induced striatal neuronal apoptosis independent of body temperature regulation. Possible mechanisms of NTR1 modulating methamphetamine-induced apoptosis include the regulation of dopamine and glutamate (Montrer GRIN1 Protéines) neurotransmission in the striatum.
The roles of neurotensin and its receptor NTR-1 on sperm capacitation and acrosome reaction in mice are reported.
sleep traits and a relationship between Ntsr1 and anxiety and despair behaviors in knockout mice
Data show that NTS1 (Montrer NTS Protéines)(-/-) mouse is an animal model of schizophrenia, particularly for the dysfunction of the prefrontal cortex.
Ntsr1 knockout mice showed a higher freezing rate than wild type mice at both first and second exposures under the condition where a relatively weak unconditioned stimulus (footshock)
Ntsr1 receptor subtype is necessary for normal dopaminergic function.
These findings support the role for Ntsr1 in the mediation of the metabolic effect of xenin (Montrer COPA Protéines) as well as neurotensin (Montrer NTS Protéines).
Neurotensin (Montrer NTS Protéines) type 1 receptor does not play a role in NT-induced analgesia, but that it is clearly implicated in thermal and feeding regulation, weight control, and NT-induced hypolocomotion.
constant activation of NT1 receptor generates an oncogenic regulation
This study strongly suggests that the addition of NTSR1 inhibitor in combination with platinum salt-based therapy will improve the response to the drug.
Our findings identify promoter methylation as an important process regulating the differential expression or silencing of NTSR1/2 in Colorectal cancer (CRC (Montrer CALR Protéines)) cells. Moreover, inhibition of NTSR1 repressed tumorigenic effects in CRC (Montrer CALR Protéines) cells, suggesting that NTSR1 may be used as a therapeutic target for CRC (Montrer CALR Protéines).
inducing exogenous neurotensin stimulation and enhancing NTR1 expression promoted tumor invasion rather than proliferation by accelerating epithelial-to-mesenchymal transition in hepatocellular carcinoma cells.
High NTR1 expression is associated with pancreatic ductal adenocarcinoma.
Data suggest that small molecule ligand binding to neurotensin receptor 1 (NTSR1) could facilitate the structure-based design of non-peptide ligands for the evaluation of the pharmacological potential of NTSR1 in neurological disorders and cancer.
The results reveal a positive feedback loop between NTS (Montrer NTS Protéines)/NTSR1 and Wnt (Montrer WNT2 Protéines)/beta-Catenin (Montrer CTNNB1 Protéines) signaling in glioblastoma cells that might be important for tumor development and provide potential therapeutic targets for glioblastoma.
NTSR1 overexpression is a poor prognostic factor in endometrial cancer, highlighting the contribution of NTS (Montrer NTS Protéines) in endometrial cancer progression
Heterodimerization of the kappa opioid receptor (Montrer OPRK1 Protéines) and neurotensin receptor 1 contributes to a novel beta-arrestin-2 (Montrer ARRB2 Protéines)-signaling pathway.
Silencing of miR-133alpha or overexpression of aftiphilin attenuated NTR1 trafficking to plasma membrane in human colonocytes.
Neurotensin (Montrer NTS Protéines) receptor-targeted oncolytic adenovirus co-expressing decorin (Montrer DCN Protéines) and Wnt (Montrer WNT2 Protéines) antagonist useful for systemic treatment of NTR-overexpressing pancreatic cancer.
Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion.
neurotensin receptor type 1
, neurotensin receptor 1 (high affinity)
, neurotensin receptor type 1-like
, high-affinity levocabastine-insensitive neurotensin receptor