Neurotensin Receptor 1 (High Affinity) Protéines (NTSR1)

Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. De plus, nous expédions NTSR1 Anticorps (93) et NTSR1 Kits (12) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
Rat NTSR1 NTSR1 366274 P20789
NTSR1 18216 O88319
NTSR1 4923 P30989
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Showing 5 out of 6 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
Cellules d'insectes Humain rho-1D4 tag,His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 40 Days
Wheat germ Humain Inconjugué   10 μg Connectez-vous pour afficher 11 to 12 Days
Escherichia coli (E. coli) Souris Inconjugué   100 μg Connectez-vous pour afficher 11 to 18 Days
Escherichia coli (E. coli) Humain Inconjugué   100 μg Connectez-vous pour afficher 11 to 18 Days

NTSR1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine) ,

Human , ,

Plus protéines pour Neurotensin Receptor 1 (High Affinity) (NTSR1) partenaires d'interaction

Mouse (Murine) Neurotensin Receptor 1 (High Affinity) (NTSR1) interaction partners

  1. Collectively, this work reveals a cellular mechanism by which neurotensi can directly engage neurotensin receptor 1-expressing DA neurons to modify dopamine signaling.

  2. The weight loss behaviors are mediated by distinct signaling pathways: Nts action via NtsR1 is essential for the anorectic effect of the lateral hypothalamic Nts circuit, but not for regulation of locomotor or drinking behavior.

  3. Authors identified a specific subset of VTA DA neurons that express neurotensin receptor-1 (NtsR1) and preferentially comprise mesolimbic, but not mesocortical, DA neurons.

  4. Data demonstrate that the NTR1 can modulate the methamphetamine-induced striatal neuronal apoptosis independent of body temperature regulation. Possible mechanisms of NTR1 modulating methamphetamine-induced apoptosis include the regulation of dopamine and glutamate neurotransmission in the striatum.

  5. The roles of neurotensin and its receptor NTR-1 on sperm capacitation and acrosome reaction in mice are reported.

  6. endogenous changes occur in NT and its receptors across multiple brain regions, and these likely support the emergence of some maternal behaviors.

  7. sleep traits and a relationship between Ntsr1 and anxiety and despair behaviors in knockout mice

  8. Data show that targeted disruption of the neurotensin receptor-1 (Ntsr1) gene reduces susceptibility to colon tumorigenesis.

  9. Data show that NTS1(-/-) mouse is an animal model of schizophrenia, particularly for the dysfunction of the prefrontal cortex.

  10. Ntsr1 knockout mice showed a higher freezing rate than wild type mice at both first and second exposures under the condition where a relatively weak unconditioned stimulus (footshock)

  11. Ntsr1 receptor subtype is necessary for normal dopaminergic function.

  12. These findings support the role for Ntsr1 in the mediation of the metabolic effect of xenin as well as neurotensin.

  13. Neurotensin type 1 receptor does not play a role in NT-induced analgesia, but that it is clearly implicated in thermal and feeding regulation, weight control, and NT-induced hypolocomotion.

  14. constant activation of NT1 receptor generates an oncogenic regulation

  15. NT and NTR1 are part of network activated after mucosal injuries, and NT stimulates epithelial restitution, at least in part, through a COX-2 dependent pathway.

  16. [(99m)Tc]Demotensin 6 shows a favourable preclinical profile and further testing in patients is warranted to monitor its eventual applicability as a radiotracer in the diagnostic imaging of NTS1-R-positive tumours.

  17. These results suggest that, without Ntsr1, synaptic responses from the LA to BLA pyramidal neurons undergo LTP in response to tetanus stimulation through facilitation of D(2)-like receptor-induced activation of NMDA receptors.

  18. Our data also suggest that the lack of Ntsr1 reduces sensitivity to the anorectic action of leptin, causing hyperphagia and abnormal weight gain.

  19. NTR1 does not play a major role in the control of basal thermoregulation, nociception or psychomotor stimulation in mice

Human Neurotensin Receptor 1 (High Affinity) (NTSR1) interaction partners

  1. NTSR1 knockdown impaired glioblastoma invasion and tumor growth through miR-494 and identified a novel mechanism by which siNTSR1 suppressed glioblastoma invasion through the miR-494/SOCS6 axis in glioblastoma.

  2. This study strongly suggests that the addition of NTSR1 inhibitor in combination with platinum salt-based therapy will improve the response to the drug.

  3. Patients with lung cancer have specific personality traits, and variations in the neurotensin receptor 1 gene may be involved in the biological mechanisms of the harm avoidance and reward dependence personality traits.

  4. Our findings identify promoter methylation as an important process regulating the differential expression or silencing of NTSR1/2 in Colorectal cancer (CRC) cells. Moreover, inhibition of NTSR1 repressed tumorigenic effects in CRC cells, suggesting that NTSR1 may be used as a therapeutic target for CRC.

  5. inducing exogenous neurotensin stimulation and enhancing NTR1 expression promoted tumor invasion rather than proliferation by accelerating epithelial-to-mesenchymal transition in hepatocellular carcinoma cells.

  6. High NTR1 expression is associated with pancreatic ductal adenocarcinoma.

  7. Data suggest that small molecule ligand binding to neurotensin receptor 1 (NTSR1) could facilitate the structure-based design of non-peptide ligands for the evaluation of the pharmacological potential of NTSR1 in neurological disorders and cancer.

  8. The results reveal a positive feedback loop between NTS/NTSR1 and Wnt/beta-Catenin signaling in glioblastoma cells that might be important for tumor development and provide potential therapeutic targets for glioblastoma.

  9. NTSR1 overexpression is a poor prognostic factor in endometrial cancer, highlighting the contribution of NTS in endometrial cancer progression

  10. characterization of the hNTS1-mediated cellular signaling network

  11. Heterodimerization of the kappa opioid receptor and neurotensin receptor 1 contributes to a novel beta-arrestin-2-signaling pathway.

  12. Silencing of miR-133alpha or overexpression of aftiphilin attenuated NTR1 trafficking to plasma membrane in human colonocytes.

  13. Neurotensin receptor-targeted oncolytic adenovirus co-expressing decorin and Wnt antagonist useful for systemic treatment of NTR-overexpressing pancreatic cancer.

  14. high expression of NTSR1 is found in clinical NETs and promoter methylation is an important mechanism controlling the differential expression of NTSR1 and silencing of NTSR2 in NET cells

  15. Data suggest that neurotensin receptor 1 (NTSR1) methylation may be a prognostic biomarker in colorectal cancers (CRCs).

  16. The presence of F358(7.42) causes the conserved W321(6.48) to adopt side chain orientation parallel to the lipid bilayer sealing the collapsed Na(+) ion pocket and linking the agonist with residues in the lower receptor part implicated in GPCR activation.

  17. This study indicated that NTR1 may play an important role in tumor progression of gastric cancer

  18. High expression levels of NTS and NTSR1 predict a poor prognosis in glioma patients.

  19. Neurotensin receptor 1 SNPs were significantly associated with processing speed in a sample of Chinese college students.

  20. the NTR1-HIF-1alpha-VEGFalpha axis has a role in intestinal angiogenic responses and in the pathophysiology of colitis and inflammatory bowel disease

Profil protéine NTSR1

Profil protéine

Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion.

Gene names and symbols associated with NTSR1

  • neurotensin receptor 1 (NTSR1)
  • neurotensin receptor 1 (high affinity) (NTSR1)
  • neurotensin receptor 1 (Ntsr1)
  • NT-1R Protéine
  • NTR Protéine
  • NTR-1 Protéine
  • NTR1 Protéine
  • Ntsr Protéine
  • NTSR1 Protéine

Protein level used designations for NTSR1

neurotensin receptor type 1 , neurotensin receptor 1 (high affinity) , neurotensin receptor type 1-like , NT-R-1 , NTR1 , NTRH , high-affinity levocabastine-insensitive neurotensin receptor

428149 Gallus gallus
458392 Pan troglodytes
485963 Canis lupus familiaris
528416 Bos taurus
698936 Macaca mulatta
100394234 Callithrix jacchus
100479759 Ailuropoda melanoleuca
366274 Rattus norvegicus
18216 Mus musculus
4923 Homo sapiens
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