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NCF2 encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. De plus, nous expédions NCF2 Protéines (12) et beaucoup plus de produits pour cette protéine.
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Human Monoclonal NCF2 Primary Antibody pour IF, WB - ABIN968245
Ago, Nunoi, Ito, Sumimoto: Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby activating dans The Journal of biological chemistry 1999
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Human Monoclonal NCF2 Primary Antibody pour IF, WB - ABIN968246
Benna, Dang, Gaudry, Fay, Morel, Hakim, Gougerot-Pocidalo: Phosphorylation of the respiratory burst oxidase subunit p67(phox) during human neutrophil activation. Regulation by protein kinase C-dependent and independent pathways. dans The Journal of biological chemistry 1997
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Human Polyclonal NCF2 Primary Antibody pour ICC, IF - ABIN4343179
Lomnytska, Becker, Bodin, Olsson, Hellman, Hellström, Mints, Hellman, Auer, Andersson: Differential expression of ANXA6, HSP27, PRDX2, NCF2, and TPM4 during uterine cervix carcinogenesis: diagnostic and prognostic value. dans British journal of cancer 2011
analysis of NCF2, BCKDHB (Montrer BCKDHB Anticorps) and BCKDHA (Montrer BCKDHA Anticorps) in pig
We analyzed the clinical and laboratory findings of CGD (Montrer CYBB Anticorps) with mutations in the NCF2 gene from amongst our cohort of CGD (Montrer CYBB Anticorps) patients. A homozygous mutation (c.835_836delAC, p.T279fsX294), a deletion in NCF2 gene was found in two cases. In the third case, two heterozygous mutations were detected, IVS13-2A>T on one allele and c.1099C>T (p.) on the other allele.
All investigated patients presented the same mutation (c.257 + 2T > C) in NCF2 gene. We show that this mutation is responsible for a drastic decrease of p67phox mRNA and leads to the skipping of exon 3 detected in the low amount of residual mRNA.
Phosphoinositol 3-phosphate regulates reactive oxygen species production by maintaining p40phox (Montrer NCF4 Anticorps) and p67phox at the phagosomal membrane.
TLR4 (Montrer TLR4 Anticorps)- and TLR2-induced IRAK (Montrer IRAK1 Anticorps)-ERK (Montrer EPHB2 Anticorps) pathway cross-talks with p67phox-Nox-2 (Montrer CYBB Anticorps) for reactive oxygen species generation, thus regulating IL-1beta (Montrer IL1B Anticorps) transcription and processing in monocytic cells.
Skeletal muscle protein expression of the NADPH oxidase (Montrer NOX1 Anticorps) subunits p22(phox (Montrer CYBA Anticorps)), p47(phox), and p67(phox) was increased in obese relative to lean subjects, where p22(phox (Montrer CYBA Anticorps)) and p67(phox) expression was attenuated by exercise training in obese subjects.
A novel homozygous mutation in NCF2.
results reveal an essential role for the Cys (Montrer DNAJC5 Anticorps)-Gly-Cys (Montrer DNAJC5 Anticorps) triad in Nox2 (Montrer CYBB Anticorps) in binding p67(phox), seconded by an additional binding region, comprising residues C terminal to Cys (Montrer DNAJC5 Anticorps)-Gly-Cys (Montrer DNAJC5 Anticorps). The 2 regions interact with distinct partner sites in p67(phox).
This model assigns a central role to Arg-395 in the structure and stability of the quaternary NCF2/NCF4 (Montrer NCF4 Anticorps)/VAV1 (Montrer VAV1 Anticorps)/RAC1 NADPH oxidase (Montrer NOX1 Anticorps) complex.
Data indicate that arachidonic acid induces the direct interaction of Rac (Montrer AKT1 Anticorps)-GTP (Montrer AK3 Anticorps)-bound p67(phox) with the C-terminal cytosolic region of phagocyte NADPH oxidase (Montrer NOX1 Anticorps) Nox2 (Montrer CYBB Anticorps).
Four novel mutations in the NCF1 (Montrer NCF1 Anticorps), NCF2, and CYBB (Montrer CYBB Anticorps) genees have been identified in chronic granulomatous disease patients in Morocco.
Just as patients with chronic granulomatous disease who lack NADPH oxidase (Montrer NOX1 Anticorps) rarely develop SLE, NCF-2-null mice on a nonautoimmune background were susceptible to a chronic granulomatous disease-like opportunistic infection but did not develop lupus. In contrast, on a lupus-prone background, even haploinsufficiency of NCF-2 accelerated the development of full-blown lupus disease.
p67(phox) binds to phosphoPrdx6 and inhibits its PLA2 (Montrer PLA2G2A Anticorps) activity, an interaction that could function to terminate the PLA2 (Montrer PLA2G2A Anticorps)-mediated NOX2 (Montrer CYBB Anticorps) activation signal.
The results of this study suggested that repeated stress promotes depressive behavior through the upregulation of NADPH (Montrer FDXR Anticorps) oxidasesubunit (67kDa (Montrer RPSA Anticorps)) and the resultant metabolic oxidative stress.
Data suggest that a cytosolic source of reactive oxygen species, probably p67(phox) subunit of cardiac NADPH oxidase 2 (NOX2 (Montrer CYBB Anticorps)), may contribute to the hypertrophic phenotype in glucose transporter 4 gene (GLUT4 (Montrer SLC2A4 Anticorps)-/-) mice.
This report evaluates neutrophil cytosolic factor 2 (Ncf2) as a candidate Salmonella susceptibility gene for Ity3.
This study demonstrates the involvement of ROS (Montrer ROS1 Anticorps) from NADPH oxidase (Montrer NOX1 Anticorps) in mediating paraquat cytotoxicity in BV-2 microglial cells and this process is mediated through PKCdelta (Montrer PKCd Anticorps)- and ERK (Montrer EPHB2 Anticorps)-dependent pathways.
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.
neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)
, neutrophil cytosolic factor 2
, neutrophil cytosol factor 2
, predicted neutrophil cytosolic factor 2
, NADPH oxidase cytosolic protein p67phox
, NADPH oxidase cytosolic protein
, 67 kDa neutrophil oxidase factor
, NADPH oxidase activator 2
, chronic granulomatous disease, autosomal 2
, neutrophil NADPH oxidase factor 2
, neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2)
, NADPH oxidase subunit (67 kD)
, NADPH oxidase subunit (67kDa)