anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) Anticorps

Mouse (Murine) Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

1. These studies demonstrate a critical role of phosphatidylinositol 3-phosphate-p40(phox) binding for optimal activation of the NADPH oxidase (Montrer NOX1 Anticorps) in macrophages.

2. Our data reveal a specific role for NCF4-mediated intracellular ROS (Montrer ROS1 Anticorps) production in regulating autoimmunity and chronic inflammation.

3. p40phox deficiency leads to upregulation of chemokine receptor 1 (Montrer CMKLR1 Anticorps) and downregulation of fucosyltransferases and sialyltransferases involved in glycan modifications during experimental intestinal inflammation.

4. cooperation of p40(phox) with p47(phox) for Nox2 (Montrer CYBB Anticorps)-based NADPH oxidase (Montrer NOX1 Anticorps) activation during Fcgamma receptor (FcgammaR)-mediated phagocytosis

5. The defect in Reactive Oxygen Species production and killing of s aureus by p40(phox-/-) neutrophils defines p40(phox) as an essential component in bacterial killing.

6. p40 (Montrer LANCL1 Anticorps)(phoxR58A/R58A) embryos do not develop normally but p40 (Montrer LANCL1 Anticorps)(phoxR58A/-) mice are viable and neutrophils from these animals exhibit significantly reduced oxidase responses compared to those from their p40(phox+/-) siblings.

7. Class III PI3K Vps34 (Montrer PIK3C3 Anticorps) is responsible for the synthesis of PtdIns(3)P on phagosomes containing either S aureus or E coli. PtdIns(3)P binding to p40(phox) is important for CD18 (Montrer ITGB2 Anticorps)-dependent activation oxidase activation in response to S aureus and E coli

8. p40(phox) is prephosphorylated in resting endothelial cells and can compensate p47(phox) in keeping basal ROS (Montrer ROS1 Anticorps) production.

Human Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

1. Phosphoinositol 3-phosphate regulates reactive oxygen species production by maintaining p40phox and p67phox (Montrer NCF2 Anticorps) at the phagosomal membrane.

2. NCF4 polymorphism was associated with Crohn's disease, but not ulcerative colitis in Caucasian--{REVIEW}

3. NCF4 may induce ex- pression of NADPH oxidase (Montrer NOX1 Anticorps) enzymes, such as p67phox (Montrer NCF2 Anticorps), p47phox, p22phox (Montrer CYBA Anticorps) and NOX2 (Montrer CYBB Anticorps), which lead to increased ROS (Montrer ROS1 Anticorps) levels.

4. Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer.

5. The contribution of the functionally relevant NADPH polymorphisms rs1883112 and rs4673 to anthracycline-related heart lesions provides a plausible explanation for their modulation of cardiotoxicity.

6. Constitutive and inducible intracellular production of reactive oxygen species (ROS (Montrer ROS1 Anticorps)) is higher in B cells expressing functional p40phox, supporting a direct role for p40phox in regulating B cell intracellular ROS (Montrer ROS1 Anticorps) generation.

7. Genome-wide association studies-reported associations between the NELL1, NCF4, and FAM92B genes and susceptibility to Crohn's disease could not be replicated in Canadian children and young adults.

8. Younger age at diagnosis, complicated disease behavior, and ileal disease location are risk factors for perianal CD. First report of an association of the NCF4 gene with perianal disease.

9. cooperation of p40(phox) with p47(phox) for Nox2 (Montrer CYBB Anticorps)-based NADPH oxidase (Montrer NOX1 Anticorps) activation during Fcgamma receptor (FcgammaR)-mediated phagocytosis

10. Results demonstrate that PBEF (Montrer NAMPT Anticorps) can prime for PMN (Montrer TBCE Anticorps) respiratory burst activity by promoting p40 (Montrer IL9 Anticorps) and p47 (Montrer ING1 Anticorps) translocation to the membrane.

Cow (Bovine) Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

1. Study proposes that NCF4 splice variants generated by functional SNP are important risk factors for mastitis susceptibility in dairy cows.